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Application of cranberry freeze-dried powder in the preparation of drugs for the prevention and treatment of familial adenomatous polyposis

A technology of freeze-dried powder and cranberry, which is applied in drug combination, freeze-dried delivery, and pharmaceutical formulations, can solve the problems of unreported research on the prevention and treatment of FAP, and achieve the goals of inhibiting polyp growth, clear curative effect, and improving quality of life Effect

Active Publication Date: 2020-05-05
GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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Problems solved by technology

In recent years, scholars at home and abroad have also found that cranberry has anti-tumor effect, but there is no report on the prevention and treatment of FAP

Method used

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  • Application of cranberry freeze-dried powder in the preparation of drugs for the prevention and treatment of familial adenomatous polyposis
  • Application of cranberry freeze-dried powder in the preparation of drugs for the prevention and treatment of familial adenomatous polyposis
  • Application of cranberry freeze-dried powder in the preparation of drugs for the prevention and treatment of familial adenomatous polyposis

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Embodiment Construction

[0015] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0016] Cranberry edible method of the present invention is: give 4 weeks old APC min / + Mice were fed 20% cranberry (wt / wt) for 12 weeks.

[0017] Cranberry to APC min / + Experiments on the effect of polyp size and number in mice

[0018] In recent years, research results have found that the dysregulation of EGFR signaling pathway is closely related to the occurrence and carcinogenesis of FAP polyps, and it is an important target for tumor prevention and treatment. Colonic polyps and tumor epithelium highly express EGFR, which stimulates its autophosphorylation through dimerization after being activated by ligands such as EGF, leading to cascade amplification and activation of downstream signaling pathways. The classic EGFR pathways mainly include: ① Mitogen-activated protein kinase pathway (Ras / Raf / MEK / ERK / MAPK pathway): by activating extracellular si...

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Abstract

The present invention discloses uses of cranberry freeze drying powder in preparation of a familial adenomatous polyposis prevention and treatment drug. According to the present invention, the cranberry freeze drying powder adopted as a diet additive with characteristics of polyp growth inhibition, accurate treatment effect and no side effect provides important significance for the clinical prevention and treatment of FAP, the improvement of patient life quality, and the reduction of recurrence; and the new safe, effective and economical method for preventing and treating FAP and multiple intestinal polyposis is provided, and has broad application prospects.

Description

technical field [0001] The invention relates to a new application of cranberries, in particular to the application of a cranberry freeze-dried powder in the preparation of drugs for preventing and treating familial adenomatous polyposis. Background technique [0002] Familial adenomatous polyposis (FAP) is an autosomal dominant genetic disease characterized by multiple adenomatous polyps in the digestive tract, and its pathogenesis is mainly related to Apc mutation. Due to the special genetic background of FAP, which is clinically multiple and prone to canceration, it has become one of the hot spots in the field of colorectal disease research. At present, there is still a lack of effective and safe methods for the prevention and treatment of FAP. At present, the prevention and treatment methods mainly include the use of cyclooxygenase-2 (COX-2) inhibitor chemoprevention and surgical prophylactic total colectomy. Celecoxib is the only chemoprevention drug approved by the US...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/45A61K9/19A61P1/00
CPCA61K9/19A61K36/45
Inventor 曹海龙王邦茂金多晨王斯南董文逍刘天宇王伟强朴美玉
Owner GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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