Preparation method, product and application of a pH-sensitive nano-sized bcl-2 selective inhibitor

A technology of bcl-2 selectivity, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the limitation of clinical treatment of Bcl-2 selective inhibitors, and cannot be too large To maximize the efficacy of the drug, lack of intracellular targeting, etc., to achieve good clinical transformation possibility, good biocompatibility, and the effect of improving drug efficacy
CN106822916BActive Publication Date: 2020-02-28ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2020-02-28

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Abstract

The invention relates to a preparation method of a pH-sensitive nano Bcl-2 selective inhibitor. The preparation method comprises the following steps: 1) dissolving amphiphilic macromolecules into a good solvent, adding a modifier with a pH responsive radical, carrying out a stirring reaction, and dialyzing to obtain a pH-sensitive amphiphilic polymer; 2) dissolving the pH-sensitive amphiphilic polymer in the step 1) and a Bcl-2 selective inhibitor into the good solvent for the stirring reaction to obtain a mixed solution; 3) carrying out rotary evaporation, dialysis and centrifugation on the mixed solution in the step 2) to obtain the pH-sensitive nano Bcl-2 selective inhibitor. The invention also relates to the prepared pH-sensitive nano Bcl-2 selective inhibitor and application thereof. The preparation reaction system is mild, the conditions are controllable, and the prepared material is good in biocompatibility and has good clinical conversion possibility.
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Description

technical field

[0001] The invention relates to the field of preparation of Bcl-2 selective inhibitors, in particular to a preparation method, product and application of pH-sensitive nanometerized Bcl-2 selective inhibitors. Background technique

[0002] Asthma is a serious respiratory disease that affects millions of people worldwide, and the number of patients is on the rise. Asthma is an inflammatory disease of the airways with multiple subtypes in which the innate and adaptive immune systems interact to cause recruitment of inflammatory cells, airway hyperresponsiveness, mucus hypersecretion, and airway remodeling.

[0003] Currently, glucocorticoids or a combination of long-term short-acting β-agonist bronchodilators (LABA or SABA) and leukotriene antagonists (LTRAs) as the first-line treatment for asthma can play a good role in most patients with asthma. treatment effect. However, there are still some asthma patients whose condition cannot be effectively controlled. ...

Claims

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