Sucrose ester dual-cleaning system-containing contact lens care solution

A contact lens and sucrose ester technology, which is applied in lens cleaning compositions, detergent compounding agents, ampholytes/electrically neutral surface active compounds, etc., can solve the problems that have not been seen in the research on sucrose ester compounding, and achieve high Biocompatibility, good decontamination, good effect of biocompatibility

Active Publication Date: 2017-06-20
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no research on the compounding of sucrose esters and other common surfactants

Method used

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  • Sucrose ester dual-cleaning system-containing contact lens care solution
  • Sucrose ester dual-cleaning system-containing contact lens care solution
  • Sucrose ester dual-cleaning system-containing contact lens care solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A contact lens care solution containing a sucrose ester double cleaning system, consisting of the following mass fractions of raw materials, with the balance being sterile water:

[0018]

[0019] The protein clearance rate is 6.92%, the lipid clearance rate is 8.10%, and the suspension quantitative sterilization test measures that the bactericidal rate to E. coli is 99.92%, the bactericidal rate to Staphylococcus aureus is 99.90%, and the bactericidal rate to Candida albicans was 94.25%, and the cell proliferation rate was 105.7%.

Embodiment 2

[0021] A contact lens care solution containing a sucrose ester double cleaning system, consisting of the following mass fractions of raw materials, with the balance being sterile water:

[0022]

[0023]

[0024] The protein clearance rate is 8.01%, the lipid clearance rate is 9.54%, the suspension quantitative sterilization test measures the bactericidal rate of Escherichia coli as 99.94%, the bactericidal rate of Staphylococcus aureus as 99.90%, and the bactericidal rate of Candida albicans was 92.37%, and the cell proliferation rate was 110.2%.

Embodiment 3

[0026] A contact lens care solution containing a sucrose ester double cleaning system, consisting of the following mass fractions of raw materials, with the balance being sterile water:

[0027]

[0028] The protein clearance rate is 10.2%, the lipid clearance rate is 11.8%, the suspension quantitative sterilization test measures the bactericidal rate to Escherichia coli of 99.99%, the bactericidal rate to Staphylococcus aureus is 100%, and the bactericidal rate to Candida albicans It was 98.90%, and the relative proliferation rate of cells was 100.1%.

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Abstract

The invention discloses a sucrose ester dual-cleaning system-containing contact lens care solution. The contact lens care solution comprises a cleanser, an antibacterial agent, a humectant, a buffering agent, an osmotic pressure regulator and a chelating agent, wherein the cleanser consists of a biological surfactant and other surfactants; the biological surfactant is a sucrose ester; the sucrose ester is taken as a cleaning component in the contact lens care solution and has effects of removing proteins and lipids; the content of the sucrose ester is 0.005 to 0.1 percent; and the other cleaning component is optionally selected from one of poloxamer 188, poloxamer 407, dimethylpropiothetin, Tetronic-1107 and Tetronic-1304. The sucrose ester dual-cleaning system-containing contact lens care solution is prepared. As the sucrose ester is taken as a primary cleaning component and forms a dual-cleaning system with the other surfactant, the care solution has very good detergency and decontamination property, can effectively clean the proteins and the lipids, and is safe, non-toxic and good in biocompatibility.

Description

technical field [0001] The invention belongs to the field of ophthalmology and relates to a contact lens care solution containing a sucrose ester double cleaning system. Background technique [0002] Biosurfactants have the advantages of acid resistance, salt resistance, biodegradability, low toxicity, antibacterial properties, no pollution to the environment and good biocompatibility. be widely used. Sucrose ester belongs to glycolipid biosurfactant and is a polyol nonionic surfactant. Its molecular structure contains multiple hydrophilic hydroxyl groups and a lipophilic long-chain alkyl group, and has a special amphiphilic structure. It is an excellent surfactant and emulsifier, which has the functions of decontamination, emulsification, solubilization, etc., and has high safety, odorless, tasteless, non-toxic, non-irritating to eyes and skin, good biocompatibility and bioavailability With strong degradability, it has been approved as a food additive and drug excipient b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11D1/825C11D1/94C11D1/835C11D3/60C11D3/48C11D3/37C11D3/33C11D3/22C11D3/04C11D3/32
CPCC11D1/42C11D1/667C11D1/722C11D1/825C11D1/835C11D1/90C11D1/94C11D3/0078C11D3/042C11D3/046C11D3/221C11D3/227C11D3/32C11D3/33C11D3/3703C11D3/3723C11D3/48
Inventor 王怡红王华甫姚琛蔡莹莹
Owner SOUTHEAST UNIV
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