A kind of plant enteric-coated hollow capsule and its production method

A technology of hollow capsules and plant intestines, applied in capsule delivery, pharmaceutical formulations, inorganic non-active ingredients, etc., can solve the problems of lack of surface uniformity, coating peeling and peeling, loss of gelatin capsule shell, etc., and achieve a safe and economical production process , the formula is simple, save the effect of coating process

Active Publication Date: 2021-01-05
HUAQIAO UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The enteric-coated capsules prepared by coating are faced with insurmountable problems and defects, such as the use of a large amount of organic solvents, the phenomenon of "orange peel" on the surface of the capsules, that is, the surface is rough, there are spots, and the lack of surface uniformity is more serious. Shedding and flaking of the coat occurs, losing the elegant, transparent appearance of the gelatin capsule shell

Method used

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  • A kind of plant enteric-coated hollow capsule and its production method

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Experimental program
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Effect test

Embodiment 1

[0038] Add 0.2 parts of potassium citrate, 0.5 parts of alginate, 0.4 parts of carrageenan, 0.2 parts of xanthan gum and 10 parts of hydroxylamine with a dynamic viscosity of 3 to 30 cP in 100 parts of distilled water heated to 85 °C while stirring. Propyl methyl cellulose, the stirring time is 0.5h, add 4 parts of water, under the conditions of temperature 85°C and vacuum degree 0.02MPa, vacuumize and defoam for 2 hours, then cool down to 55°C naturally for 5 hours and then dip in Glue to form a film, cross-link in a calcium chloride solution with a concentration of 5.0wt% for 300s, wash twice, and dry for 2 hours at a relative humidity of 36% and a temperature of 40°C to obtain plant enteric-coated hollow capsules.

Embodiment 2

[0040]Add 4.0 parts of potassium chloride, 2.0 parts of algin, 0.3 parts of gellan gum, 0.3 parts of konjac gum and 20 parts of konjac gum with a dynamic viscosity of 3 to 30 cP in 100 parts of distilled water heated to 85 °C while stirring. Hydroxypropyl starch, the stirring time is 2 hours, 4 parts of water, under the conditions of temperature 85 ℃ and vacuum degree 0.04MPa, vacuumize and remove bubbles for 3 hours, then naturally cool down to 55 ℃ for 3 hours and then dip the glue to form The film was cross-linked in a calcium citrate solution with a concentration of 10.0wt% for 100s, washed 4 times, and dried for 2 hours at a relative humidity of 36% and a temperature of 45°C to obtain plant enteric-coated hollow capsules.

Embodiment 3

[0042] Add 0.5 parts of potassium citrate, 5.0 parts of alginate, 0.3 parts of gellan gum, 0.4 parts of locust bean gum and 10 parts of hydroxybenzene with a dynamic viscosity of 3 to 30 cP in 100 parts of distilled water heated to 90 °C while stirring. Propyl cellulose, the stirring time is 4 hours, 4 parts of water, under the condition of temperature of 85 ℃ and vacuum degree of 0.06MPa, vacuumize and defoam for 2 hours, then naturally cool down to 55 ℃ for 2 hours and dip in the glue to form The film was cross-linked in a calcium lactate solution with a concentration of 5.0wt% for 50s, washed three times, and dried for 4 hours at a relative humidity of 36% and a temperature of 35°C to obtain plant enteric-coated hollow capsules.

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Abstract

The invention discloses a plant enteric empty capsule and a production method thereof. The method is characterized in that compound plant glue is treated as a gel; a cellulose deviate is used as a film-forming agent and a disintegrating agent; potassium ions are used as a coagulant for preparing mixed glue liquid; the vacuum defoaming, glue dipping and film forming, ionic crosslinking, constant-temperature low-humidity drying and other processes are carried to prepare the not-gelatin plant enteric empty capsule excluding synthetic resin. According to the method, the traditional gelatin is replaced by safe and economic plant glue, so that the possible potential risk of the gelatin in eating can be overcome; an original gelatin enteric empty capsule production technology is improved; the complex and tedious coating process is eliminated; the method is safe and economic; the production processes are simple.

Description

technical field [0001] The invention relates to an enteric-coated hollow capsule, in particular to a plant enteric-coated hollow capsule and a production method thereof. Background technique [0002] Capsule production has a history of more than 170 years and is an old dosage form that has been used for a long time. Because capsules have the characteristics that oral preparations such as pills do not have, such as convenient use, covering the smell and taste of drugs, fast drug release speed, accurate dosage, good stability, and easy storage, capsules are still a better alternative. dosage form. Considering the bioavailability of the drug, the production of capsules is much superior to that of tablets. At present, there are more and more types of capsules produced abroad, such as common hard capsules, enteric-coated capsules, sustained-release capsules, soft capsules, etc., especially enteric-coated capsules, because of their unique enteric-coated properties, they have att...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/36A61K47/38A61K47/02A61K47/10A61K47/26
CPCA61K9/4816
Inventor 肖美添叶静张娜黄雅燕张学勤李晓辉
Owner HUAQIAO UNIVERSITY
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