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Biocompatible polysulfone membrane modified by sulfonated hydroxypropyl chitosan and its preparation method

A technology of sulfonated hydroxypropyl chitosan and sulfonated hydroxypropyl shell, which is applied in the field of sulfonated hydroxypropyl chitosan modified polysulfone membrane and its preparation, and can solve the problems of cumbersome process, platelet adsorption, deformation, etc. problems, to achieve the effects of mild and easy-to-control reaction conditions, improved biocompatibility, and low-cost process raw materials

Inactive Publication Date: 2019-05-21
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional polysulfone biocompatibility is not ideal. When in direct contact with blood, there are the following problems: the surface of the membrane is easily polluted by blood proteins, and long-term contact will lead to the adsorption of blood proteins, which will further cause the adsorption of platelets. and deformation, eventually leading to the formation of thrombus
However, they have the following disadvantages: the modified material is expensive and the process is cumbersome; the hydrophilicity of the material is not studied from the coagulation mechanism; the use of heparin is easy to cause complications

Method used

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  • Biocompatible polysulfone membrane modified by sulfonated hydroxypropyl chitosan and its preparation method
  • Biocompatible polysulfone membrane modified by sulfonated hydroxypropyl chitosan and its preparation method
  • Biocompatible polysulfone membrane modified by sulfonated hydroxypropyl chitosan and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0049] Take 15g CS as raw material, first alkalinize it with NaOH solution with a concentration of 10moL / L, add it into the reactor together with 150ml IPA and 150ml PO, stir and react at 45°C for 4h, then pour it into deionized water to dissolve and neutralize , followed by acetone precipitation, suction filtration, washing and drying to obtain HPCS. Mix 2ml of CSA and 20ml of formamide in an ice-salt bath to make a sulfonation reagent, then add 2g of HPCS, stir and react at 68°C for 3h, and undergo dialysis, deamination, redialysis, concentration and drying to obtain SHPCS.

[0050] Add 250ml chloroform to the flask, add 10g PSf and dissolve, add 28.5ml TMCS, 6.7g PFA and 0.26ml SnCl 4 , stirred at 45°C under nitrogen protection for 72h, precipitated with methanol, vacuum filtered and dried to obtain PSf-Cl. Then dissolve PSf-Cl in N,N-dimethylacetamide with a mass fraction of 18%, configure it as a casting solution, first shake it to dissolve, then let it stand for defoami...

Embodiment 2

[0053] Take 15g CS as raw material, first alkalinize it with NaOH solution with a concentration of 10moL / L, add it into the reactor together with 150ml IPA and 150ml PO, stir and react at 45°C for 4h, then pour it into deionized water to dissolve and neutralize , followed by acetone precipitation, suction filtration, washing and drying to obtain HPCS. 4ml of CSA and 20ml of formamide were formulated into a sulfonation reagent in an ice-salt bath, then 2g of HPCS was added, the reaction was stirred at 68°C for 3h, and SHPCS was obtained by dialysis, deamination, redialysis, and concentration and drying.

[0054] Add 250ml chloroform to the flask, add 10g PSf and dissolve, add 28.5ml TMCS, 6.7g PFA and 0.26ml SnCl 4 , stirred at 45°C under nitrogen protection for 72h, precipitated with methanol, vacuum filtered and dried to obtain PSf-Cl. Then dissolve PSf-Cl in N,N-dimethylacetamide with a mass fraction of 18%, configure it as a casting solution, first shake it to dissolve, th...

Embodiment 3

[0057] Take 15g CS as raw material, first alkalinize it with NaOH solution with a concentration of 10moL / L, add it into the reactor together with 150ml IPA and 150ml PO, stir and react at 45°C for 4h, then pour it into deionized water to dissolve and neutralize , followed by acetone precipitation, suction filtration, washing and drying to obtain HPCS. 4ml of CSA and 20ml of formamide were formulated into a sulfonation reagent in an ice-salt bath, then 2g of HPCS was added, the reaction was stirred at 68°C for 3h, and SHPCS was obtained by dialysis, deamination, redialysis, and concentration and drying.

[0058] Add 250ml chloroform to the flask, add 10g PSf and dissolve, add 28.5ml TMCS, 6.7g PFA and 0.26ml SnCl 4 , stirred at 60°C under nitrogen protection for 72h, precipitated with methanol, vacuum filtered and dried to obtain PSf-Cl. Then dissolve PSf-Cl in N,N-dimethylacetamide with a mass fraction of 18%, configure it as a casting solution, first shake it to dissolve, th...

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Abstract

The invention relates to a sulfonated hydroxypropyl chitosan modified biocompatible polysulfone membrane and a preparation method thereof. The preparation method comprises the steps of chloromethylating polysulfone firstly so as to obtain chloromethylated polysulfone, and preparing a chloromethylated polysulfone membrane through a phase conversion method; using the chloromethylated polysulfone membrane as a base membrane and performing amination treatment on the chloromethylated polysulfone membrane, so as to obtain an aminated polysulfone membrane; and sulfonating chitosan so as to obtain sulfonated hydroxypropyl chitosan, and grafting a sulfonated hydroxypropyl chitosan hydrophilic side chain on the surface of the aminated polysulfone membrane through Schiff base reaction, so as to obtain the sulfonated hydroxypropyl chitosan modified biocompatible polysulfone membrane. The outstanding feature of the preparation method is to directly bond the sulfonated hydroxypropyl chitosan with a heparitin structure on the surface of the polysulfone membrane, so that the hydrophilicity, anticoagulation and anti-bacterial property are greatly enhanced. The preparation method is easy, the reaction conditions are mild and easy to control, and the preparation cost is low.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a sulfonated hydroxypropyl chitosan modified polysulfone membrane and a preparation method thereof. Background technique [0002] Polysulfone has good mechanical properties such as wear resistance, high elasticity and high strength, and has high-flux permeability. Catheters and medical materials. However, the traditional polysulfone biocompatibility is not ideal. When in direct contact with blood, there are the following problems: the surface of the membrane is easily polluted by blood proteins, and long-term contact will lead to the adsorption of blood proteins, which will further cause the adsorption of platelets. and deformation, eventually leading to the formation of thrombus. The invention aims to solve the problems of thrombus and the like generated when the polysulfone material is used, and provides a modified polysulfone membrane material with good biocompatibility a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D71/78B01D67/00B01D69/02
CPCB01D67/0006B01D69/02B01D71/78
Inventor 邱运仁刘天明
Owner CENT SOUTH UNIV
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