Tumor immune response enhancing complex

A technology of anti-tumor immunity and compound, applied in the field of biomedicine, can solve the problem of inability to remove necrosis factors, etc., and achieve the effect of improving the inhibitory function

Inactive Publication Date: 2017-07-21
JIANGSU FOOD & PHARMA SCI COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Most of the existing complexes that enhance anti-tumor immune response are obtained by combining heat shock protein 70 or heat shock prote

Method used

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Embodiment Construction

[0010] In order to make the objects and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0011] The embodiment of the present invention provides a complex for enhancing anti-tumor immune response, which is obtained by combining tumor cell mixed peptide, salmon ovary peptide, and heat shock protein 70 in vitro; the tumor cell mixed peptide is a mixed peptide obtained from tumor cells; The tumor cell mixed peptide contains tumor-specific antigen peptide

[0012] This specific implementation uses basic biochemical techniques such as cell freeze-thawing, heating precipitation, and acid treatment to obtain mixed peptides from tumor cells; combine heat shock protein 70 with salmon ovary peptides and the resulting mixed peptides in vitro, ...

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Abstract

The invention discloses a tumor immune response enhancing complex. The tumor immune response enhancing complex is formed through in vitro binding of tumor cell peptides, salmon ovarian peptides and heat shock protein 70, wherein the tumor cell peptides are peptides obtained from tumor cells and contain tumor specific antigen peptides. The tumor immune response enhancing complex can inhibit growth of tumor cells and meanwhile eliminate tumor necrosis factors, thereby greatly enhancing the function of inhibiting tumor growth.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a compound for enhancing anti-tumor immune response. Background technique [0002] Most of the existing complexes that enhance anti-tumor immune response are obtained by combining heat shock protein 70 or heat shock protein 90 with tumor cell mixed peptides. Although they can inhibit the growth of tumor cells to a certain extent, they cannot remove necrosis factors . Contents of the invention [0003] In order to solve the above problems, the present invention provides a complex for enhancing anti-tumor immune response, which can remove necrosis factors while inhibiting tumor cell growth, thereby greatly improving the inhibitory function on tumor growth. [0004] In order to achieve the above object, the technical scheme that the present invention takes is: [0005] A complex for enhancing anti-tumor immune response, which is obtained by combining tumor cell mixed peptide, salmon o...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P35/00A61K38/02
CPCA61K38/02A61K38/17A61K2300/00
Inventor 张君丽葛驰宇
Owner JIANGSU FOOD & PHARMA SCI COLLEGE
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