A Method of Using Correlation Coefficient to Process Drug Database Data
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A correlation coefficient and data processing technology, applied in the field of database management, can solve the problems of model applicability, limited accuracy, high cost, and large investment, and achieve the effects of small limitations, strong openness, and improved practicability
Active Publication Date: 2019-04-05
NAT INST FOR FOOD & DRUG CONTROL
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The above two methods not only need to try a large number of complex algorithms, but also the applicability and accuracy of the transformed model are still relatively limited, which cannot fundamentally solve the problem of large investment and high cost in modeling. More effective methods need to be found to Make up for the shortcomings of near-infrared spectroscopy in practical applications
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Embodiment 1
[0062] Example 1: Construction and Application of Tablet Near-infrared Spectral Library
[0063] The first part, the construction of tablet near-infrared spectral library
[0064] Tablets refer to tablet-shaped solid preparations made by mixing and pressing drugs and suitable excipients. It is one of the most widely used varieties in modern pharmaceutical preparations. Tablets for oral use are divided into: tablets, coated tablets , Effervescent Tablets, Chewable Tablets, Dispersible Tablets, Sustained Release Tablets, Controlled Release Tablets, Multilayer Tablets, Orally Disintegrating Tablets. Tablet varieties (m=4) in the existing drug library were sorted out, including sparfloxacin tablets (n=73, spectral collection method: aluminum-plastic or direct contact measurement), clarithromycin sustained-release tablets ( n=54, spectrum collection method: aluminum-plastic insulation) and amoxicillin dispersible tablets (n=65, spectrum collection method: direct contact measuremen...
Embodiment 2
[0080] Example 2: Construction and application of powder injection near-infrared spectral library
[0081] The first part, the construction of powder injection near-infrared spectral library
[0082] Powder injection is a powdery article formed by mixing drugs and reagents, and then sterilized and dried. According to the preparation principle, it can be divided into sterile powder and freeze-dried powder.
[0083] Sort out the types of powder injections in existing medicines (m=6), including ceftriaxone sodium for injection (n=118, spectrum acquisition method: vials), ceftizoxime sodium for injection (n=110, spectrum Collection method: vial vial), cefuroxime sodium for injection (n=32, spectrum collection method: vial vial), cefotaxime sodium for injection (n=29, spectral collection method: vial vial), Cefoperazone Sodium for Injection (n=40 samples, spectrum acquisition method: vial vial), cefepime hydrochloride for injection (n=35 samples, spectral acquisition method: vial ...
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Abstract
The invention relates to a method for drug storage data processing by correlation coefficients, in particular to a method for drug near-infrared spectrum data integration, library building and application to unknown drug physicochemical index quick determination. The method includes drug near-infrared spectrum library building and spectrum library application in quick and accurate analysis of quality of to-be-tested drugs. A basic idea includes: dividing drug data according to dosage forms, building a drug near-infrared spectrum library according to the dosage forms, and drawing an orderly distribution diagram namely a frequency and correlation coefficient histogram of all samples according to drug near-infrared spectrum correlation coefficients under the premise of a same dosage form to complete spectrum library building; determining similar varieties of to-be-tested varieties and reference samples on the basis of the correlation coefficients, and subjecting known physicochemical values and the similar varieties and the reference samples of near-infrared spectra to unified modeling to obtain a quick quantitative model of indexes required by to-be-tested quality, so that application of the near-infrared spectrum library is realized. The method is suitable for detection of all varieties and all indexes under the same dosage form.
Description
technical field [0001] The invention relates to the technical field of database management, in particular to a method for processing drug library data using correlation coefficients, that is, a method for integrating near-infrared spectral data from drugs, building a library, and applying it to the rapid determination of unknown drug physical and chemical indicators. Background technique [0002] Near-infrared spectroscopy detection technology has the characteristics of non-destructive, no pretreatment, no pollution, real-time, etc. It has been widely used in pharmaceutical and drug supervision, including the analysis of raw materials, the analysis of intermediates in the pharmaceutical process, and the analysis of pharmaceutical preparations. Even analysis of packaged pharmaceuticals is included. However, the current near-infrared detection technology generally relies on the established calibration analysis model, and the establishment of the model needs to measure the phys...
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