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Fuyuan Xingnao granule preparation and its preparation method and application

A granule preparation, a refreshing technology, which is applied in the directions of pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., to achieve uniform appearance in color, uniform particle size, and good fluidity.

Active Publication Date: 2020-12-29
上海市浦东新区浦南医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there is no granule preparation of Fuyuan Xingnao Decoction

Method used

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  • Fuyuan Xingnao granule preparation and its preparation method and application
  • Fuyuan Xingnao granule preparation and its preparation method and application
  • Fuyuan Xingnao granule preparation and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Extraction and preparation method of Fuyuan Xinnaoqing Ointment

[0023] 1. Fuyuan Xingnao Extract No. 1 (decoction extraction, water precipitation)

[0024] Weighing: 200g ginseng, 240g leeches, 180g ginseng, 180g rhubarb (add after 1 hour of first decoction), 300g panax notoginseng, 1100g in total; add water to decoct twice, the temperature is 100°C, and the ratio of material to liquid is the first The first time is 10 times, the second time is 8 times, the extraction time is 120 minutes for the first time, and 80 minutes for the second time, and the filtrates are combined.

[0025] Concentrate under reduced pressure to a relative density of 1.20 (60°C) to obtain 412.10 g of Fuyuan Xinnaoqing Ointment.

[0026] 2. Fuyuan Xingnao Extract No. 2 (ethanol reflux extraction, water decoction extraction, water precipitation)

[0027] Weighing: 200 grams of ginseng, 180 grams of Radix Ginseng, 300 grams of Panax notoginseng, a total of 680 grams; reflux twice wit...

Embodiment 2

[0038] Example 2: Animal experiment of Fuyuan Xinnaoqing ointment for treating ischemic cerebrovascular disease

[0039] The pharmacological experiment of making the local cerebral ischemia model by rat suture method is to verify that the drug has the effect of preventing and treating ischemic cerebrovascular disease. Blood protection.

[0040] 1 animal

[0041] Healthy male SD rats, weighing 240-270 g, were kept in a clean animal room.

[0042] 2 drugs

[0043] The experimental rats were divided into groups, 8 in each group.

[0044] Sham operation group: given the same amount of normal saline as the drug experiment group, without cerebral ischemia operation;

[0045] Model group (negative control group): given the same amount of normal saline as the drug experimental group, and underwent cerebral ischemia surgery;

[0046] Drug group 1: low dose of Fuyuan Xinnaoqing Ointment No. 1;

[0047] Drug group 2: high dose of Fuyuan Xinnaoqing Ointment No. 1;

[0048] Drug gro...

Embodiment 3

[0066] Example 3: Optimization of Extraction Process of Fuyuan Xinnao Extract No. 3

[0067] The optimization of the extraction process of Fuyuan Xinnao Extract No. 3 is divided into three parts.

[0068] 1 Optimization of ethanol reflux extraction process

[0069] 1.1 Ginseng, Radix Ginseng, Sanqisan herbal decoction pieces, reflux extraction with ethanol as solvent, using L 9 (3 4 ) Orthogonal test method to optimize the ethanol reflux extraction process. We selected four factors and three levels of each factor for orthogonal experiments. See Table 3.

[0070] Table 3 Factor levels of orthogonal test of ethanol reflux extraction process

[0071]

[0072] 1.2 Ethanol reflux extraction process L 9 (3 4 ) Orthogonal test

[0073] Ethanol reflux extraction process L 9 (3 4 ) Orthogonal test: Weigh 20g of ginseng, 18g of Tiannanxing, 30g of Panax notoginseng, 68g in total. Add different concentrations and different multiples of ethanol, heat and reflux extraction fo...

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Abstract

The invention relates to a recovery refreshing granular preparation and a preparation method and an application thereof. The recovery refreshing granular preparation is composed of the following raw medicinal materials: 200g of ginseng, 240g of leeches, 180g of prepared rhizoma arisaematis, 180g of rheum officinale and 300g of pseudo-ginseng. The preparation method comprises the following steps: performing reflux extraction on ginseng, prepared rhizoma arisaematis, rheum officinale and pseudo-ginseng with ethanol; after adding the leeches and rheum officinale into filter residues, decocting and extracting the filter residues with water; performing precipitation with ethanol; performing concentration to prepare a clear paste; and adding auxiliary materials into the concentrated clear paste to prepare the recovery refreshing granular preparation. An extraction process of the recovery refreshing formula clear paste is established and optimized, effective components in the recovery refreshing formula can be fully extracted to play roles of breaking blood and removing stasis, dispelling wind and removing stasis and consolidating constitution and tonifying qi, the curative effect on ischemic cerebrovascular disease is remarkable, and a formula meeting the requirement of the granular preparation is obtained.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a novel preparation extraction process for preparing Fuyuan Xinnao Granules, the Fuyuan Xinnao Granule preparation prepared by the process and the application of the Fuyuan Xinnao Granule preparation. Background technique [0002] Fuyuan Xinnao Decoction is a prescription developed on the basis of many years of clinical use. Clinically, the decoction is given to patients orally, and it mainly treats central nervous system diseases caused by decreased cerebral blood flow. Traditional decoctions have the advantages of simple preparation, fast absorption, and rapid curative effect, but there are also some disadvantages in decoctions, such as large decoction, bitter taste, inconvenient to carry and take, and easy to mold, ferment, and deteriorate. And can not be stored for a long time, should not be produced in batches and quality is not easy to control etc. [0003] Granules ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/8884A61K47/36A61P25/00A61P9/10A61K35/62
CPCA61K9/1652A61K35/62A61K36/258A61K36/708A61K36/8884A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 李铁军刘卫东方邦江徐中菊李莉冯晶晶钱萍秦春霞孙莉莉丁华敏钱俞君陈国良
Owner 上海市浦东新区浦南医院