Composition of L-5-methyltetrahydrofolate or pharmaceutically acceptable salt thereof and pharmaceutical adjuvants and preparing method thereof

Abstract

A composition of L-5-methyltetrahydrofolate or a pharmaceutically acceptable salt thereof and pharmaceutical excipients and a production method thereof, comprising L-5-methyltetrahydrofolate or a pharmaceutically acceptable salt thereof and pharmaceutical excipients, L-5-methyltetrahydrofolate or its pharmaceutically acceptable salts are in an amorphous state, and there is no L after deducting the background peak of the pharmaceutical excipients in the X-ray powder diffraction spectrum of the composition -Characteristic peaks of crystals of 5-methyltetrahydrofolate or its salts. The composition of L-5-methyltetrahydrofolate or its pharmaceutically acceptable salt and pharmaceutical excipients of the present invention has good stability and dispersibility, and increases the dissolution of L-5-methyltetrahydrofolate or its salt It is more conducive to improving the bioavailability of pharmaceutical preparations and the absorption of drugs by the body. Under accelerated test conditions, it can maintain good physical and chemical stability. The preparation method of the amorphous composition of the invention is simple in operation, low in cost, good in reproducibility, easy to implement and suitable for industrialized production.

Description

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AI Technical Summary

Benefits of technology

This patented technology describes methods for combining different types of ingredient(L-5-MTHFLIPIDES®or other substances together). By doing this, stable compositions containing these compounds may become available at room temperature without losing their effectiveness due to melting during storage. Additionally, they provide improved properties when added to various medical products like tablets or capsules. Overall, this approach provides technical benefits over existing techniques while avoiding certain drawbacks associated therewith.

Problems solved by technology

This patented describes different ways to make certain drugs like lithium hydroxypropyltriflate or gamma valerolide better suited for medical purposes because they have fewer negative side effects compared to other medicants currently available on market. However, their physical properties can change over time if stored at high temperatures which makes them less effective when taken by patients who require frequent blood tests. To address this problem, researchers explored various techniques involving combining two compounds together called α-,β-unsaturated glucuronosulfoferrumie acid ("α - methoxytetrol," abbreviators). These combinations were found to provide improved results without compromising any beneficial aspects associated with each individual component separately.

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