The invention relates to a composite plugging agent for a space station. The composite plugging agent is divided into a part A and a part B, wherein specifically the part A comprises, by weight. 10-30parts of an epoxy resin, 1-5 parts of a diluent, 0.1-5 parts of a nano powder filler, 0.3-0.5 part of a suspension dispersant, 5-20 parts of a toughening agent, and 1-15 parts of a micron-scale or millimeter-scale filler, and the part B comprises, by weight, 10-50 parts of a curing agent, 5-25 parts of a coupling agent, 1-10 parts of an accelerant, and 1-15 parts of a micron-scale or millimeter-scale filler. According to the composite plugging agent for the space station, the use amount of the suspension dispersing agent is greatly reduced, good suspension and good dispersion of the nano-powder filler can still be achieved, the curing strength of the plugging agent is improved, and the curing time is shortened.