Application of giant molecular weight hyaluronic acid in naked mole rats in the preparation of breast cancer drugs

A technology of hyaluronic acid and naked mole rats, which can be used in drug combinations, medical preparations containing active ingredients, anti-tumor drugs, etc., and can solve problems such as serious physical damage

Active Publication Date: 2020-08-14
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, breast cancer chemotherapy is very harmful to the body. Chemotherapy drugs kill normal cells as well as cancer cells

Method used

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  • Application of giant molecular weight hyaluronic acid in naked mole rats in the preparation of breast cancer drugs
  • Application of giant molecular weight hyaluronic acid in naked mole rats in the preparation of breast cancer drugs
  • Application of giant molecular weight hyaluronic acid in naked mole rats in the preparation of breast cancer drugs

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Experimental program
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Effect test

specific Embodiment approach 1

[0028] Embodiment 1: The application of naked mole rat giant molecular weight hyaluronic acid in the preparation of drugs for treating breast cancer in this embodiment.

[0029] 4T1 and BT549 cells overexpressing the Has2 gene of naked mole rats can secrete hyaluronic acid with a huge molecular weight (molecular weight reaches 6MDa). In vitro experiments showed that giant molecular weight hyaluronic acid can significantly promote the apoptosis and inhibit proliferation of 4T1 and BT549 cells: the ratio of EdU-positive cells in the 4T1 overexpression naked mole rat Has2 genome and the addition of giant molecular weight HA group was 30-40% lower than that in the control group ;The ratio of EdU positive cells in BT549 overexpression of naked mole rat Has2 gene group and the addition of giant molecular weight HA group was about 20% lower than that of the control group, and the expression level of PCNAmRNA in the overexpression naked mole rat Has2 gene group and addition of giant mo...

specific Embodiment approach 2

[0030] Embodiment 2: This embodiment differs from Embodiment 1 in that: naked mole rat giant hyaluronic acid is used to promote the apoptosis of BT549 cells and inhibit the proliferation of BT549 cells. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0031] Embodiment 3: This embodiment differs from Embodiment 1 or Embodiment 2 in that the giant molecular weight hyaluronic acid of naked mole rats is used to promote the apoptosis of 4T1 cells and inhibit the proliferation of 4T1 cells. Others are the same as those in Embodiment 1 or 2.

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Abstract

The invention discloses an application of naked mole rat giant molecular weight hyaluronic acid in the preparation of drugs for treating breast cancer, and relates to the application of the naked mole rat giant molecular weight hyaluronic acid. The prepared giant molecular weight hyaluronic acid belongs to the integral components in human body tissues and does not cause harm to patients; prepared hydrogel by using the giant molecular weight hyaluronic acid can achieve local delayed-release treatment, and is functional only for breast cancer lesion sites without hurting other normal tissues, and the hydrogel has no side effects, the operation is simple. The application of the naked mole rat giant molecular weight hyaluronic acid in the preparation of the drugs for treating breast cancer relates to the field of pharmaceuticals.

Description

technical field [0001] The invention relates to the application of naked mole rat giant molecular weight hyaluronic acid in the preparation of drugs for treating breast cancer. Background technique [0002] With the development of medicine, the treatment methods for breast cancer patients are becoming more and more perfect, but there will still be corresponding side effects during the treatment process. [0003] Disadvantages of surgical treatment of breast cancer: [0004] Surgical treatment for patients with mid-stage breast cancer can maximize the local control of the primary tumor and regional lymph nodes, allow for a more thorough resection of the lesion, and improve the survival rate of patients. However, when breast cancer develops to the middle stage, the patient's physique is relatively weak, and metastasis may have occurred. After blind surgery, it is very likely that the patient's physique will be greatly weakened, which will bring difficulty to recovery, and it...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/728A61P35/00
CPCA61K31/728
Inventor 田维明赵玉芳乔书培
Owner HARBIN INST OF TECH
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