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Mercapto-carboxyl dual-modified mesoporous silica nanoparticles and preparation method therefor

A mesoporous silica and nanoparticle technology, applied in the field of medicine, can solve the problems of limiting the application of drug delivery, fast release speed, and narrow application range, so as to increase drug loading, control drug release, and increase hydrophilicity Effect

Inactive Publication Date: 2017-08-18
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The existing silica mesoporous materials have disadvantages such as narrow application range and weak hydrophilicity, and in the field of drug loading and drug controlled release, the drug loading is low and the release rate is too fast, which limits its application in the field of drug delivery

Method used

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  • Mercapto-carboxyl dual-modified mesoporous silica nanoparticles and preparation method therefor

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Embodiment 1

[0030] (1) Preparation of mesoporous silica nanoparticles (MSN)

[0031] Mix 2.35ml (70.5mmol) ethanol, 0.56g (1.755mmol) cetyltrimethylammonium chloride (CTAC), 16ml (0.9mol) ultrapure water, add 2.6ml (0.0192mol) triethanolamine, stir To dissolve, heat up to 60°C, blow nitrogen, add 1.454ml (6.5mmol) tetraethyl orthosilicate (TEOS) dropwise at a certain speed (1mL / min), react for 2h, end the reaction, cool to room temperature, centrifuge ( 10000r / min, 15min), washed with water and ethanol respectively and centrifuged, dispersed in 90ml ethanol and 10ml hydrochloric acid (37%) mixed solution system, refluxed twice at 60°C for 2h each time. After reflux, wash with water and ethanol respectively, centrifuge and dry in vacuum (65°C, 12h).

[0032] (2) Preparation of mercapto mesoporous silica nanoparticles (MSN-SH)

[0033] Mix 2.35ml (70.5mmol) ethanol, 0.56g (1.755mmol) cetyltrimethylammonium chloride (CTAC), 16ml (0.9mol) ultrapure water, add 2.6ml (0.0192mol) triethanolami...

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Abstract

The invention relates to mercapto-carboxyl dual-modified mesoporous silica nanoparticles and a preparation method therefor and belongs to the technical field of medicines. The preparation method for the mercapto-carboxyl dual-modified mesoporous silica nanoparticles comprises the steps: (1) preparing mercaptopropyl modified mesoporous silica nanoparticles; and (2) preparing the mercapto-carboxyl dual-modified mesoporous silica nanoparticles. The product has the mean particle size of 50nm to 200nm. Through mercapto modification, covalent drug loading can be carried out, a mesoporous silica drug loading system with oxidation-reduction response is prepared, and the release of drugs is effectively controlled; and through a carboxyl charge action, the drug loading capacity of alkalescent drugs can be improved, the release speed is high in case of small pH, and the toxic or side effects on normal tissue caused by the drugs can be lowered, so that the product has a broad application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a mesoporous silica nano-particle modified with mercapto carboxyl groups and a preparation method thereof. Background technique [0002] As a technical method with the advantages of improving drug bioavailability, controlling drug release rate, and changing drug distribution in vivo, nano drug delivery system has become a research hotspot in the fields of pharmacy and bionanomaterials. In the field of research and development, people mainly use new nanomaterials as carriers to realize drug loading by covalently linking drugs and physically embedding drugs, so as to overcome the problems of low bioavailability, large toxic and side effects, and poor selectivity of traditional drugs, and improve Drug efficacy and safety. [0003] Nano-mesoporous materials have a series of advantages such as highly ordered pores, uniform and adjustable pore size, high specific surface ...

Claims

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Application Information

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IPC IPC(8): C01B33/12A61K47/52A61K9/14A61P35/00
CPCC01B33/12C01P2002/82C01P2004/04C01P2004/51C01P2004/62
Inventor 刘明星王瑜
Owner HUBEI UNIV OF TECH
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