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Composition for preventing or treating obesity containing alpha-lipoic acid and n-acetylcysteine as active ingredients

A technology of acetylcysteine ​​and an active ingredient, applied in the field of compositions for preventing or treating obesity, can solve problems such as side effects, and achieve the effects of reducing side effects and excellent inhibitory effect

Inactive Publication Date: 2017-08-29
THE ASAN FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the above-mentioned components are administered alone, the effect is excellent only at high concentrations, and there is a risk of drug-induced side effects

Method used

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  • Composition for preventing or treating obesity containing alpha-lipoic acid and n-acetylcysteine as active ingredients
  • Composition for preventing or treating obesity containing alpha-lipoic acid and n-acetylcysteine as active ingredients

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0037] Experimental example 1. Confirmation of the weight gain inhibitory effect of combined administration of α-lipoic acid and N-acetylcysteine

[0038] In order to confirm that the weight gain inhibitory effect of combined administration of α-lipoic acid and N-acetylcysteine ​​is significantly superior to that of single administration of α-lipoic acid or N-acetylcysteine, the following experiments were performed .

[0039] Specifically, 7-week-old C57 / BL6J male mice were divided into control group, α-lipoic acid administration group, N-acetylcysteine ​​administration group, α-lipoic acid and N-acetylcysteine In the acid combination administration group, 7-week-old C57 / BL6J male mice were given a high-fat diet consisting of 60% fat, 18% protein, and 22% carbohydrate without restriction. At the same time, α-lipoic acid was added to the diet at concentrations of 0.05%, 0.1%, and 0.2% in the α-lipoic acid-administered group for 3 weeks, and in the N-acetylcysteine-administered...

preparation example 1

[0043] Formulation example 1. Formulation of pharmaceutical composition

[0044] 1-1. Preparation of powder

[0045] 20mg blend of alpha-lipoic acid and N-acetylcysteine

[0046] 100mg of lactose

[0047] 10mg of talc

[0048] The above-mentioned ingredients are mixed, and filled in a confidential bag to prepare a powder.

[0049] 1-2. Preparation of tablet

[0050] 10mg of a mixture of alpha-lipoic acid and N-acetylcysteine

[0051] 100mg cornstarch

[0052] 100mg of lactose

[0053] 2mg magnesium stearate

[0054] After mixing the above-mentioned ingredients, tableting is carried out according to a usual tablet manufacturing method to prepare tablets.

[0055] 1-3. Preparation of capsules

[0056] 10mg of a mixture of alpha-lipoic acid and N-acetylcysteine

[0057] 3mg of crystalline cellulose

[0058] 14.8mg of lactose

[0059] 0.2 mg magnesium stearate

[0060] The above ingredients are mixed according to a usual capsule production method, and filled in gelati...

preparation example 2

[0073] Formulation example 2. Formulation of food composition

[0074] 2-1. Preparation of health food

[0075] 100mg blend of alpha-lipoic acid and N-acetylcysteine

[0076] Right amount of vitamin blend

[0077] 70 μg vitamin A acetate

[0078] 1.0mg Vitamin E

[0079] 0.13mg of vitamin B1

[0080] 0.15mg of Vitamin B2

[0081] 0.5mg vitamin B6

[0082] 0.2 μg of vitamin B12

[0083] 10mg of Vitamin C

[0084] 10 μg biotin

[0085] 1.7mg of Niacinamide

[0086] 50 μg of folic acid

[0087] 0.5mg calcium pantothenate

[0088] Proper amount of inorganic matter mixture

[0089] 1.75 mg of ferrous sulfate

[0090] 0.82mg of zinc oxide

[0091] 25.3mg magnesium carbonate

[0092] 15mg calcium phosphate

[0093] 55mg dibasic calcium phosphate

[0094] 90mg Potassium Citrate

[0095] 100mg calcium carbonate

[0096] 24.8mg magnesium chloride

[0097]The combination ratio of the above-mentioned vitamin and mineral mixture is formed by mixing ingredients suitable ...

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Abstract

The present invention relates to a composition containing alpha-lipoic acid and N-acetylcysteine as active ingredients. The mixture composition of alpha-lipoic acid and N-acetylcysteine of the present invention reduces the risk of side effects caused by drugs and has an excellent effect of suppressing weight gain compared with each single composition containing alpha-lipoic acid or N-acetylcysteine, due to the synergistic effect resulting from the combined administration of the two drugs, and thus the composition of the present invention can be favorably used for the prevention or treatment of obesity.

Description

technical field [0001] The present invention relates to a composition for preventing or treating obesity comprising α-lipoic acid and N-acetylcysteine ​​as active ingredients. Background technique [0002] Obesity refers to the state of excessive accumulation of fat in the body. The World Health Organization (WHO) diagnoses as follows: The main reason for the increase in obesity in the world is that the content of vitamins, minerals and other micronutrients is low, and the food with high energy The frequency of ingestion is high, and the reduction of body movements based on changes in transport units, etc. That is, it is considered that the root cause of obesity is an energy imbalance in which more calories are consumed than consumed. In particular, obesity becomes a accelerator for the induction of lifestyle-related diseases, increases the risk of type 2 diabetes and arteriosclerosis, puts a burden on the blood supply to the heart and induces heart disease, and excess fat ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/385A61K31/195A23L33/10A61P3/04
CPCA23L33/10A61K9/0019A61K9/08A61K9/145A61K9/2018A61K9/4858A61K31/385A23L33/12A23L33/175A23V2002/00A61K9/0095A61K31/198A61P3/00A61P3/04A23V2200/332A23V2250/026A23V2250/0634A23V2250/156A23V2250/1578A23V2250/1592A23V2250/16A23V2250/161A23V2250/1618A23V2250/1642A23V2250/702A23V2250/7042A23V2250/7044A23V2250/7052A23V2250/7056A23V2250/706A23V2250/708A23V2250/712A23V2250/72A61K31/195A23L33/40
Inventor 李起业朴重烈高银熙张贞恩李仁奎
Owner THE ASAN FOUND
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