Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of preparation method of chitin nanogel

A nano-gel, chitin technology, applied in the fields of chemistry, environment, medicine, and natural polymers, can solve the problems of small preparation amount, difficulty in mass production, toxicity, etc., and achieve the effect of simple method

Active Publication Date: 2019-04-09
奥美佰玛(武汉)生物科技有限公司
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the method uses organic solvents such as methanol, which has certain toxicity, and the preparation amount is small, so it is difficult to produce in large quantities.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of preparation method of chitin nanogel
  • A kind of preparation method of chitin nanogel
  • A kind of preparation method of chitin nanogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Add chitin powder into a solution containing 8wt% NaOH and 4wt% urea, and cycle freeze twice at -30°C to dissolve it into a homogeneous chitin solution, wherein the content of chitin is 0.5wt%. Use a disperser to stir at a speed of 10,000 r / min for 30 minutes to obtain a milky white dispersion. Finally, the milky white dispersion was dialyzed in ultrapure water for 6 days to neutral, and a uniformly dispersed chitin nanogel could be obtained.

[0025] Its microscopic morphology was observed with a scanning electron microscope, and it was found that it was composed of nano-scale particles. Observing with a transmission electron microscope, it can be clearly seen that the diameter of the chitin nanogel is 10-30nm. The prepared chitin nanogel was characterized by Fourier transform infrared spectrometer, which showed that the characteristic groups of chitin did not change before and after the reaction, which indicated that the reaction process was a physical process. Rese...

Embodiment 2

[0027] Add chitin powder into a solution containing 8wt% NaOH and 4wt% urea, and cycle freeze twice at -30°C to dissolve it into a homogeneous chitin solution, wherein the content of chitin is 0.5wt%. After stirring with a disperser at a speed of 3000r / min for 30 minutes, the system is still a transparent chitin homogeneous solution, and nanogels cannot be formed, indicating that the formation of nanogels is related to the stirring speed.

Embodiment 3

[0029] Chitin powder was added into a solution containing 8wt% NaOH and 4wt% urea, and cyclically frozen at -25°C for 3 times to dissolve into a homogeneous chitin solution, wherein the content of chitin was 1wt%. Use a disperser to stir at a speed of 10,000 r / min for 30 minutes to obtain a milky white dispersion. The milky white dispersion is dialyzed in distilled water for about 7 days to neutral, and a uniformly dispersed chitin nanogel can be obtained.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method of chitin nanogel. The preparation method comprises the following steps: adding chitin powder into an aqueous solution with 6 to 12 weight percent of NaOH and 2 to 8 weight percent of urea, and performing cyclic freezing, thus obtaining a uniformly dissolved chitin solution, wherein the content of chitin is 0.2 to 4 weight percent; then stirring the chitin solution at a speed of 5,000 r / min or a higher speed, thus obtaining a milk white disperse solution; dialyzing the obtained milk white disperse solution into ultrapure water till the disperse solution is neutral, thus obtaining the uniformly dispersed chitin nanogel, wherein the diameter of the chitin nanogel is about 20 nm. The process is simple and easy to operate; furthermore, the chitin nanogel can be prepared in a large scale; the chitin nanogel has wide application potential to environment treatment, biomedicines and other aspects.

Description

technical field [0001] The invention belongs to the field of natural macromolecules, and also belongs to the fields of chemistry, environment and medicine, and specifically relates to a method for preparing chitin nanogel and the chitin nanogel obtained by the method. Background technique [0002] Chitin, also known as chitin, chitin, and chitin, is the polysaccharide that exists in the earth second only to cellulose, and is also the nitrogen-containing natural organic polymer compound with the largest amount in nature except protein. Chitin has unique physical, chemical and biological properties, mainly including: multifunctional group reactivity, antibacterial properties, biocompatibility, biodegradability, etc. Nanogels have many excellent properties, such as large specific surface area, high drug loading capacity, and more sensitive stimuli responsiveness to the environment. Chitin nanogel combines the advantages of both, and further expands the application range of chi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08J3/05C08L5/08
CPCC08J3/05C08J3/075C08J2305/08
Inventor 施晓文张建伟邓红兵杜予民
Owner 奥美佰玛(武汉)生物科技有限公司