New pharmaceutical use of Naozhenning preparation

A technology of brain shock and preparations, applied in the direction of pill delivery, drug combination, pharmaceutical formula, etc.

Active Publication Date: 2017-09-22
SHANXI ZHENDONG ANTE BIOPHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, there are no FDA-approved drugs

Method used

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  • New pharmaceutical use of Naozhenning preparation
  • New pharmaceutical use of Naozhenning preparation
  • New pharmaceutical use of Naozhenning preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Embodiment 1: Brain Zhenning Extract

[0098] Brain Zhenning extract is a refined product made according to the prescription disclosed in the patent No. 931007410.

[0099] Prescription: Angelica 200g, Rehmannia glutinosa 200g, Moutan bark 150g, Chuanxiong 150g, Dilong 150g, Salvia miltiorrhiza 375g, Poria cocos 250g, tangerine peel 250g, Zhuru 250g, fried jujube kernel 250g, Baiziren 250g.

[0100] Preparation method: the above eleven flavors, angelica, moutan cortex, chuanxiong, and tangerine peel are distilled to extract volatile oil, then add other medicinal materials to extract with water, filter, and concentrate into a thick paste to obtain Zhenzhenning extract.

Embodiment 2

[0101] Embodiment 2: Naozhenning Granules

[0102] Sucrose-free Naozhenning granules were prepared according to standard WS3-B-3312-98-1.

[0103] Prescription: Angelica 200g, Rehmannia glutinosa 200g, Moutan bark 150g, Chuanxiong 150g, Dilong 150g, Salvia miltiorrhiza 375g, Poria cocos 250g, tangerine peel 250g, Zhuru 250g, fried jujube kernel 250g, Baiziren 250g.

[0104] The above eleven flavors, Angelica, Moutan Cortex, Chuanxiong, and Tangerine Peel are distilled to extract volatile oils, and the distilled aqueous solution is collected in a separate device; the dregs and the other seven flavors such as Salvia Miltiorrhiza are decocted twice, each time for 1.5 hours, and the decoctions are combined and filtered. Combine the filtrate with the above aqueous solution, concentrate to a clear paste with a relative density of 1.35-1.38 (55°C), add appropriate amount of sucrose and dextrin, granulate, dry, add the above-mentioned volatile oil, mix well, and make 1000g; Ningyouta...

Embodiment 3

[0105] Embodiment 3: Naozhenning Capsules

[0106] Prescription: Angelica 220g, Rehmannia glutinosa 210g, Moutan bark 160g, Chuanxiong 140g, Dilong 130g, Salvia miltiorrhiza 330g, Poria cocos 260g, tangerine peel 260g, Zhuru 260g, fried Suanzaoren 160g, Baiziren 160g.

[0107] Preparation method: the above eleven flavors, angelica, peony bark, chuanxiong, tangerine peel are distilled to extract volatile oil, and then add other medicinal materials for water extraction. After water extraction, use 80% ethanol to sink twice, concentrate into a thick paste, add appropriate amount of Mix the starch evenly, granulate, dry and granulate, add the obtained volatile oil, and stir evenly to prepare 200 Naozhenning capsules, each containing 0.4g.

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PUM

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Abstract

The invention relates to new pharmaceutical use of a Naozhenning preparation. As a traditional Chinese medicinal preparation, Naozhenning is widely applied in treatment of patients with cerebral concussion. The invention finds that through application of Naozhenning to a mouse traumatic brain injury model, cell death in the cortex and hippocampus are both less than that of a blank group, and the cortex defect degree is lighter than that of the blank group. At the same time, Naozhenning has an outstanding protective effect on cortical axons after injury, and also has certain degree of protection on dendritic branches and dendritic branch total length. Tests show that Naozhenning has neuroprotective effect on traumatic brain injury.

Description

technical field [0001] The invention relates to a new medical application of a drug, in particular to a new medical application of a marketed drug, Zhenningning preparation. Background technique [0002] Traumatic Brain Injury (TBI) is an important cause of disability in people under the age of 45. In North America and Europe, the incidence of traumatic brain injury is about 500 / 100,000 people per year. The World Health Organization predicts that between 2000 and 2020, the number of road traffic deaths (most of which are due to traumatic brain injuries) will double and continue to increase, mainly in low-middle-income countries in a traffic accident. By 2020, traumatic brain injury will become the third leading cause of disability and death worldwide (WHO, 2009). [0003] On the other hand, acute and chronic risk factors related to concussions caused by sports in adolescents also deserve attention. Accumulating evidence shows that patients with a history of multiple mino...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K9/20A61P25/28A61K35/62
CPCA61K9/2059A61K35/62A61K36/076A61K36/14A61K36/232A61K36/236A61K36/537A61K36/65A61K36/71A61K36/725A61K36/752A61K36/804A61K36/899A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 李昆陈锦辉朱平秦正国范玛莉刘海霞
Owner SHANXI ZHENDONG ANTE BIOPHARMACEUTICAL CO LTD
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