Medicinal composition for treating secondary trigeminal neuralgia

A technology for trigeminal neuralgia and a composition is applied in the field of applied drugs in neurology and pharmaceutical compositions for treating secondary trigeminal neuralgia, and can solve the problems of long recovery period, great pain and high risk

Inactive Publication Date: 2017-09-26
臧运华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are particularly sensitive trigger points in the distribution area of ​​the trigeminal nerve, and the pain is often limited to one or more branches of the unilateral trigeminal nerve. Trigeminal neuralgia is also closely related to facial microvascular, the main reason is that adjacent blood vessels compress the trigeminal nerve root, most of them are small glue arteries compressing the nerve root from the upper or inner upper part of the trigeminal nerve root, a few Because the anterior inferior cerebellar artery compresses the nerve root from below the root of the trigeminal nerve, as a response, the more commonly used methods in clinical practice focus on neurosurgery, peripheral branch avulsion, amputation, and trigeminal nerve tractectomy It is suitable for patients of all ages, and it is relatively painful, high-risk, and expensive; in the field of neurology, most of them can only passively control and alleviate the disease by taking carbamazepine or alcohol injection, but the treatment effect is poor , long recovery period, and easy recurrence. Carbamazepine, the first choice drug for trigeminal neuralgia, is difficult to be used for a long time due to its large side effects or high risk

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1: Measure Scorpion, Tortoise Shell, Cassia, Calculus Bezoar, Bear Gallbladder, Yuanhu, Dried Blood, Sanleng, Calamus, Nansha Ginseng, Gansong, Chuanbei, Polygonatum Polygonatum, Vitex, Cinnamon, Bailing according to the formula Grass, dodder, and hippocampus decoction pieces are crushed into powdered medicine and passed through a 50-mesh sieve. After the sieved powdered medicine is soaked in deionized water at 45°C for half an hour, filter the medicinal residue with gauze, wrap the medicinal residue with the gauze Tie the mouth, put it into an automatic decoction machine, add 2500g of water, decoct at normal temperature and pressure for 3 hours, remove the medicine bag, and divide the obtained medicinal liquid to obtain decoction A.

Embodiment 2

[0044] (1) Monarch medicine decoction: Take twice the formula amount of scorpion, tortoise shell, cassia seed, bezoar, and bear bile decoction pieces, pulverize into powdered medicine, pass through a 100-mesh sieve, and pour the sieved powdered medicine into 45°C deionized water After soaking for 1 hour, filter the medicinal mud with a double-layer non-woven fabric, wrap the medicinal mud with the double-layer non-woven fabric and tie the mouth, put it into an automatic decoction machine, add 200g of water, and cook at a working pressure of 170kPa and a temperature of 130°C. Decoct at ℃ for 1 hour, remove the non-woven medicine bag, add 10g of honey to the medicinal liquid, continue to decoct for 2 hours under normal temperature and pressure, until the medicinal liquid is concentrated into a paste, and the Junyao ointment is obtained;

[0045] (2) Decoction of ministerial medicine: Take the decoction pieces of Yuanhu, Xueshen, Sanleng and Acorus calamus in the prescribed amount...

Embodiment 3

[0050] (1) Pretreatment of raw materials: take three times the amount of the formula of scorpion, tortoise shell, cassia seed, bezoar, and bear bile; Pine, Chuanbei, Polygonatum odoratum, Vitex, cinnamon, lark, dodder, hippocampus, pulverized and mixed, added 1200g deionized water, decocted at normal temperature and pressure for 6 hours, filtered once to obtain the medicinal solution, and poured into the filter residue Add 800g of deionized water, decoct at a pressure of 80kPa and a temperature of 120°C for 4 hours, filter to obtain a secondary medicinal solution, add 400g of deionized water to the residue, and decoct for 2 hours at a pressure of 170kPa and a temperature of 130°C. Filtrate the medicinal liquid for three times; combine the first, second, and third medicinal liquids above, add 300g honey to the combined medicinal liquid, continue to decoct for 3 hours under normal temperature and pressure difference, until the medicinal liquid is concentrated into a paste, and th...

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PUM

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Abstract

The invention relates to a medicinal composition for treating secondary trigeminal neuralgia. The medicinal composition is prepared from the following crude drugs: scorpion, carapax et plastrum testudinis, semen cassiae, calculus bovis, bear gall, rhizoma corydalis, sangusis draconis, rhizoma sparganii, rhizoma acori graminei, radix adenophorae, nardostachyos root and rhizome, bulbus fritillariae cirrhosae, rhizoma polygonati odorati, fructus viticis, cortex cinnamomi, marsdenia longipes, semen cuscutae and sea horse, wherein monarch drugs comprise the scorpion, the carapax et plastrum testudinis and the semen cassiae; ministerial drugs comprise the rhizoma corydalis, the sangusis draconis, the calculus bovis and the bear gall; adjuvant drugs comprise the radix adenophorae, the nardostachyos root and rhizome, the bulbus fritillariae cirrhosae and the rhizoma polygonati odorati; conductant drugs comprise the fructus viticis, the cortex cinnamomi, the marsdenia longipes, the semen cuscutae and the sea horse. According to the medicinal composition disclosed by the invention, all the drugs are mutually coordinated while realizing respective effectiveness; all the components are compounded together to achieve unexpected technical effects in the aspect of treating the secondary trigeminal neuralgia; the medicinal composition has the advantages of rapid effect, high efficiency, short treatment course, low possibility of recurrence and the like; besides, a unique four-phase separation process is easy to grasp, apply and promote.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, relates to a neurology medicine, in particular to a medicine composition for treating secondary trigeminal neuralgia. Background technique [0002] Trigeminal neuralgia is a common disease in neurology. It is characterized by recurrent paroxysmal severe pain in the trigeminal nerve distribution area on one side of the face. The symptoms are characterized by sudden onset and sudden arrest in the trigeminal nerve distribution area of ​​the head and face. , Lightning-like, knife-like, burning-like, intractable, unbearable severe pain, which affects normal life and work. According to domestic statistics, the incidence rate of this disease is about 52 cases per 100,000 people. Among them, secondary trigeminal neuralgia is a relatively common type in the classification of trigeminal neuralgia. Secondary trigeminal neuralgia generally lasts for a long time, and there are obvious pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/902A61K9/08A61P25/02A61K35/646A61K35/60A61K35/586A61K35/413
CPCA61K9/0095A61K35/413A61K35/586A61K35/60A61K35/646A61K36/27A61K36/342A61K36/39A61K36/43A61K36/482A61K36/54A61K36/66A61K36/84A61K36/85A61K36/888A61K36/889A61K36/896A61K36/8966A61K36/8969A61K36/902A61K47/46A61K2236/331A61K2300/00
Inventor 臧运华高向慧郑志轩王群周喜燕
Owner 臧运华
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