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Systems and methods for spinal cord stimulation

A technology of stimulation device and side effects, applied in electrotherapy, therapy, physical therapy, etc., can solve problems such as non-realization

Active Publication Date: 2017-09-29
DUKE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods may not be optimal as they neither search for nor implement parameters that have been algorithmically determined to be optimal for efficacy (reduction of neural activity associated with pain relief), efficiency (power consumption), and reduction of paresthesias

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  • Systems and methods for spinal cord stimulation
  • Systems and methods for spinal cord stimulation
  • Systems and methods for spinal cord stimulation

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Embodiment Construction

[0081] Any dimensions shown or implied in the drawings and these descriptions are provided for exemplary purposes. Accordingly, not all embodiments within the scope of the drawings and these descriptions may be made according to such exemplary dimensions. The drawings are not necessarily drawn to scale.

[0082] These descriptions involve the use of search heuristics (genetic algorithms) coupled with biophysical models of pain circuits in the spinal cord to optimize the temporal signature of the SCS in such a way that nociceptive information from the spinal cord is suppressed, power consumption (efficiency) is reduced, And reduce neural signals associated with paresthesia side effects. Computational modeling work has shown that the activity of wide dynamic range (WDR) neurons in the spinal cord that propagate nociceptive information (pain signals) to the brain depends on the frequency with which SCS is applied, and that novel temporal signals that provide SCS can be used to m...

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Abstract

The invention discloses systems and methods for spinal cord stimulation. According to the invention, optimizing temporal pulse patterns for stimulation delivery to a subject includes: generating a first generation pulse pattern; delivering stimulation according to the first generation pattern to a subject; measuring efficacy, efficiency and side-effect parameters affected by the delivered stimulation; determining a fitness of the first generation pattern using the measured parameters; generating a second generation pattern using the first generation pattern according to the determined fitness of the first generation temporal pattern; and delivering stimulation according to the second generation pattern. Iterative further optimization may include crossing any particular generation temporal pulse pattern with at least one other temporal pulse pattern to generate offspring patterns for further use and optimization. Immigrant random patterns may be added, and offspring patterns may receive point mutations. Optimization may be conducted using a computational model prior to treatment of a human subject and further optimization may occur using feedback from the subject.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Application No. 62 / 055798, entitled "Optimized Systems and Methods for Stimulating the Spinal Cord," published September 26, 2014, the entire contents of which are hereby incorporated by reference. technical field [0003] The subject matter of the present disclosure relates to spinal cord stimulation, and more specifically to facilitating the efficacy, efficiency and side effects of spinal cord stimulation (SCS) based on the use of electrical temporal signals. Background technique [0004] Spinal cord stimulation (SCS) has emerged as a potentially viable treatment for chronic pain, while other treatments such as kinetics (physical rehabilitation), drugs, and surgery have shown little efficacy. However, studies have shown that the clinical efficacy of SCS is highly variable and has shown little improvement in recent years. Conventional clinical SCS is often accompanie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/08A61N1/36
CPCA61N1/36132G16H50/50A61N1/36139G16Z99/00A61N1/36071A61N1/37217A61N1/37247
Inventor 沃伦·M·格瑞张天河
Owner DUKE UNIV