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Methods of preventing and treating bronchopulmonary dysplasia using high fat human milk products

A stunted, high-fat technology for applications, dairy products, functions of food ingredients, etc., which can solve the problems of time-consuming, increased protein concentration, and expensive calorie content

Pending Publication Date: 2017-10-13
PROLACTA BIOSCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Initial efforts to increase the caloric content of human milk focused on increasing the protein content (see, e.g., U.S. Patent No. 8,545,920, which is hereby incorporated by reference in its entirety), however, increasing the caloric content through protein concentration is an expensive and time-consuming process

Method used

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  • Methods of preventing and treating bronchopulmonary dysplasia using high fat human milk products
  • Methods of preventing and treating bronchopulmonary dysplasia using high fat human milk products
  • Methods of preventing and treating bronchopulmonary dysplasia using high fat human milk products

Examples

Experimental program
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Effect test

example 1

[0110] Human Milk Cream Fortifier Products

[0111] In order to provide a nutritional supplement that would increase human milk or donor milk by a desired amount of calories without adding significant bulk, an enterally deliverable human cream fortifier composition was prepared, thereby avoiding the adverse effects associated with TPN. Human milk from pre-screened and audited donors is blended together to create a pool of donor milk. The pool of donor milk was further tested for specific pathogens and bovine proteins in a clean room environment. Specifically, PCR tests were used to screen for the presence of HIV-1, HBV, and HCV in dairy products. Microbial plates for tests such as aerobic counts, Bacillus cereus, E. coli, Salmonella, Pseudomonas, coliforms, Staphylococcus aureus, yeast and mold were also performed.

[0112] The pool of donor milk was ultracentrifuged to produce a cream fraction and a skim milk fraction. The cream fraction was then formulated to meet specifi...

example 2

[0116] Standardized high fat human milk composition

[0117] In order to provide a standardized ready-to-feed formulation that can deliver large amounts of heat without adding significant volume, an enterally deliverable high fat human milk human composition was created, thereby avoiding the adverse effects associated with TPN. Human milk from pre-screened and audited donors is blended together to create a pool of donor milk. The pool of donor milk was further tested for specific pathogens and bovine proteins in a clean room environment. Specifically, PCR tests were used to screen for the presence of HIV-1, HBV, and HCV in dairy products. Microbial plates for tests such as aerobic counts, Bacillus cereus, E. coli, Salmonella, Pseudomonas, coliforms, Staphylococcus aureus, yeast and mold were also performed.

[0118] figure 1 is a diagram showing an example of producing a human milk fortifier. The screened, combined dairy product undergoes filtration (eg, through an approx...

example 3

[0126] Human Milk Cream Products Cause Shorter Hospital Stays in Extremely Preterm Infants

[0127] In a multicentre trial, infants were supplied with an exclusive human milk diet according to the institute's standard feeding regimen. This diet consists of human milk or pasteurized donor human milk Prolact+H fortified with a pasteurized donor HM-derived fortifier 2 MF (Prolacta Biotech, CA). After obtaining informed consent, infants were randomized into two groups by a block for four members whose size was blinded. Due to logical reasons, the shielding of the research group can only be realized at the Land Reform Research Institute.

[0128]After infants began to tolerate a fortified enteral diet (approximately 100cc / kg / d), a near-infrared dairy analyzer (Spectrastar 2400RTW; Unity Scientific, Brookfield Connecticut) Start dairy analysis. The Institute did not analyze the basic dairy supply of infants in the control group according to standard practice. Infants randomized...

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Abstract

The disclosure features a human milk cream composition, standardized high fat human milk formulations as well as methods of making and using such compositions. In particular, the disclosure features a method of using a human milk cream composition and / or standardized high fat human milk formulations to treat infants with bronchopulmonary dysplasia (BPD) or at risk of developing BPD.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Patent Application Serial No. 62 / 098,151 filed December 30, 2014, the contents of which are incorporated herein by reference in their entirety. technical field [0003] The present invention generally relates to high fat human milk, such as standardized human cream compositions, methods of making said compositions, and methods of using said compositions. Background technique [0004] Human milk is an ideal source of nutrition for premature infants, offering advantages in host defense, gastrointestinal maturation, infection rates, neurodevelopmental outcome, and long-term cardiovascular and metabolic disease (Schanler, R.J., Human Milk Feeding Outcomes of human milk-fed premature infants. Perinatology Papers (Semin Perinatol), 2011.35(1): pp. 29-33). An exclusive human milk-based diet significantly reduced the rates of necrotizing enterocolitis (NEC), sepsis, days of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23C13/14
CPCA23V2002/00A23L33/40A23C13/14A61P11/00A23V2200/314A23L33/10A23C9/152A23C9/206A23L2/52
Inventor M·李S·埃尔斯特J·富尔耐尔
Owner PROLACTA BIOSCI
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