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Application of hydrogen molecule liquid/gas in preparation of drugs for inhibiting tumor stem cells

A technology of tumor stem cells and hydrogen molecules, applied in the application field of hydrogen molecule liquid/gas in the preparation of drugs for inhibiting tumor stem cells

Inactive Publication Date: 2017-10-24
BEIJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, whether hydrogen or hydrogen-rich water can inhibit tumor stem cells is still not reported

Method used

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  • Application of hydrogen molecule liquid/gas in preparation of drugs for inhibiting tumor stem cells
  • Application of hydrogen molecule liquid/gas in preparation of drugs for inhibiting tumor stem cells
  • Application of hydrogen molecule liquid/gas in preparation of drugs for inhibiting tumor stem cells

Examples

Experimental program
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Effect test

Embodiment 1

[0022] (1) Preparation of hydrogen-containing medium in cell culture

[0023] 1. After the magnesium rod is autoclaved, it is placed in the cell culture medium. After two days, the hydrogen concentration in the medium reaches saturation and is ready for use.

[0024] 2. The 100% volume ratio pure hydrogen generated by electrolyzed water is passed into the medium for a certain period of time (50mL 30min), at which point the hydrogen concentration in the medium reaches saturation and is ready for use.

[0025] (2) Treatment of hydrogen group in animal glioma model

[0026] 1. In the animal model of the breathing hydrogen group, hydrogen is generated by electrolyzing water, and the mixed gas containing 60% hydrogen and air is passed into the animal incubator for the animals to breathe.

[0027] 2. In the animal model of drinking hydrogen-rich water, the experimental animals drink hydrogen-rich water containing saturated hydrogen molecules. Hydrogen-rich water is prepared by ele...

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Abstract

The invention provides an application of hydrogen molecule liquid / gas in preparation of drugs for inhibiting tumor stem cells, belonging to the technical field of preparation of drugs for inhibiting tumor stem cells. By applying the liquid / gas containing hydrogen molecules in preparation of drugs for inhibiting tumor stem cells, the tumor formation capability in tumors is obviously inhibited, the invasion ability of tumor cells is obviously reduced, the expression of surface markers CD133 of tumor stem cells is obviously inhibited, and the expression of differentiation markers is promoted.

Description

technical field [0001] The invention belongs to the technical field of preparation of drugs for inhibiting tumor stem cells, and in particular relates to the application of hydrogen molecule liquid / gas in the preparation of drugs for inhibiting tumor stem cells. technical background [0002] In recent years, as studies have found that tumors are not composed of uniform tumor cells, different cells in tumors have different abilities to proliferate, invade and metastasize, and have strong heterogeneity. A small part of the cells has the potential of self-renewal, unlimited proliferation and multi-directional differentiation. These cells are called cancer stem cells (CSC). Tumors and the initial cells that initiate the rapid proliferation of tumors can also produce new tumor cells through continuous differentiation to form complete tumors. Cancer stem cells are also considered to be the culprit of drug resistance and recurrence, and finding effective drugs to inhibit glioma st...

Claims

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Application Information

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IPC IPC(8): A61K33/00A61P35/00
CPCA61K33/00A61K2300/00
Inventor 马雪梅刘梦昱阎新龙谢飞赵鹏翔商蕾王婷婷
Owner BEIJING UNIV OF TECH
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