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Detection method for traditional Chinese medicine composition capable of eliminating toxin and relieving sore throat and application thereof

A detection method, a detoxification and pharyngeal technology, which are applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., and can solve the problems of lack of detection methods for traditional Chinese medicine compositions, inappropriate content determination, and inability to content determination.

Inactive Publication Date: 2017-11-03
TONG REN TANG TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, there is no detection method for the traditional Chinese medicine composition for detoxifying and relieving sore throat in the prior art; The traditional Chinese medicine composition is composed of seven kinds of traditional Chinese medicines such as brocade lantern, burdock fruit, platycodon grandiflorum, and licori

Method used

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  • Detection method for traditional Chinese medicine composition capable of eliminating toxin and relieving sore throat and application thereof
  • Detection method for traditional Chinese medicine composition capable of eliminating toxin and relieving sore throat and application thereof
  • Detection method for traditional Chinese medicine composition capable of eliminating toxin and relieving sore throat and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] The raw materials of the traditional Chinese medicine composition for detoxification and sore throat in this embodiment consist of: 15g brocade lantern, 15g Radix Isatidis, 10g Andrographis paniculata, 10g Burdock Fructus, 6g Platycodon grandiflorum, 6g mint, 10g licorice;

[0073] Preparation is carried out according to the following preparation method: take brocade lantern, isatis root, Andrographis paniculata, burdock seed, bellflower, mint and licorice according to selected weight parts, add water to decoct twice, each time for 1.5 hours, and use brocade lantern, isatis root, Andrographis paniculata, burdock Based on the total weight of the fruit, bellflower, mint and licorice, add 10 times the weight of water each time, filter the decoction, combine the filtrate, and concentrate the filtrate under reduced pressure to a clear paste with a relative density of 1.20 to 1.25 at 50°C. Instantly.

[0074]The traditional Chinese medicine composition for detoxifying and rel...

Embodiment 2

[0076] The detection method of the traditional Chinese medicine composition of the present embodiment detoxifying and relieving sore throat comprises the following methods:

[0077] A, the content assay method of luteolin, comprises the steps:

[0078] Preparation of the test solution: take 1 g of the Chinese medicine composition to be tested, weigh it accurately, place it in a stoppered conical flask, add 25 mL of methanol aqueous solution with a volume concentration of 70%, extract it ultrasonically for 0.5 hour, let it cool, and weigh it again. Weight, make up the lost weight with 70% methanol aqueous solution, shake well, and filter to get final product;

[0079] Preparation of the reference substance solution: take an appropriate amount of the luteolin reference substance, weigh it accurately, add methanol aqueous solution with a volume concentration of 70% to make a solution with a concentration of 20 μg / mL, and obtain it;

[0080] Chromatographic conditions: determined...

Embodiment 3

[0103] The detection method of the traditional Chinese medicine composition of the present embodiment detoxifying and relieving sore throat comprises the following methods:

[0104] A, the assay method of luteolin, comprises the following steps:

[0105] Preparation of the test solution: take 0.5 g of the Chinese medicine composition to be tested, accurately weighed, put in a stoppered conical flask, accurately add 10 mL of methanol aqueous solution with a volume concentration of 80%, ultrasonically extract for 1.0 hour, let cool, and weigh again. Determine the weight, make up the lost weight with an aqueous methanol solution with a volume concentration of 80%, shake well, and filter to obtain final product;

[0106] Preparation of reference substance solution: take an appropriate amount of luteolin reference substance, accurately weigh it, add methanol aqueous solution with a volume concentration of 90% to make a solution with a concentration of 5 μg / mL, and obtain it;

[01...

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Abstract

The invention relates to a detection method for a traditional Chinese medicine composition capable of eliminating toxin and relieving sore throat and application thereof. According to the detection method in the invention, the content of luteoloside in Chinese lantern plant is selected as a detection index, and a proper gradient elution method is selected so as to allow optimal separation effect to be exerted on luteoloside and other chemical components in the traditional Chinese medicine composition, the content of luteoloside in the traditional Chinese medicine composition can be accurately determined; the detection method is accurate, sensitive, simple and has good stability and repeatability and an excellent HPLC chromatogram peak pattern, so the content of luteoloside in the traditional Chinese medicine composition can be accurately determined; moreover, a method for determining the content of luteoloside, a method for identifying arctium fruit, a method for identifying balloonflower roots and a method for identifying licorice roots are combined together for evaluating the quality of the traditional Chinese medicine composition capable of eliminating toxin and relieving sore throat, so the quality of the traditional Chinese medicine composition can be effectively controlled and the safety and stability in usage of the traditional Chinese medicine composition are improved.

Description

technical field [0001] The invention belongs to the field of drug analysis, and in particular relates to a detection method and an application of a traditional Chinese medicine composition for detoxifying and relieving sore throat. Background technique [0002] Acute pharyngitis is an acute inflammation of the pharyngeal mucosa and submucosal tissues. The main causes of disease are viral infection, bacterial infection and environmental factors. It is mostly transmitted by droplets or direct contact, and is often secondary to acute tonsillitis or acute rhinitis. It can occur alone, and it is a common and frequently-occurring disease in clinical practice. In severe cases, it can cause many complications and endanger health. [0003] At present, the treatment of acute pharyngitis is mainly based on antiviral drugs, and others include antibiotics and hormones, but there are problems such as relatively large toxic and side effects. [0004] The theory of traditional Chinese medi...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/90A61K36/81A61P11/04A61P29/00A61P31/00
CPCG01N30/02A61K36/19A61K36/195A61K36/28A61K36/315A61K36/346A61K36/484A61K36/534A61K36/81G01N30/90A61K2300/00
Inventor 杜菁王海姚璐魏弘宜张蓓
Owner TONG REN TANG TECH CO LTD
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