The invention discloses a Dendrobium officinale beautifying wine for strengthening stomach, invigorating spleen and lowering blood lipid. The raw materials include Dendrobium officinale, American ginseng, lotus leaf, hawthorn, Ligusticum wallichii, Ganoderma lucidum, soybean, rhizoma polygonati, Polygonum multiflorum, Ligustrum lucidum, rheum officinale, Coptis chinensis, Astragalus mongholicus, licorice, acanthopanax senticosus, the root of kudzu vine, Chinese yam, Schisandra chinensis, ginkgo leaf, Citrus aurantium L., Poria cocos, mulberry, Chinese lantern plant, wolfberry fruit, edible alcohol, a fruit and vegetable extraction agent, highly flavored type base liquor, highly flavored type flavoring liquor with alcoholic strength of 60-70%vol and pure water. The invention also provides a preparation method of the Dendrobium officinale beautifying medicinal liquor for strengthening stomach, invigorating spleen and lowering blood lipid. The prepared medicinal liquor has the effects of strengthening stomach, invigorating spleen, lowering blood lipid and beautifying.