A preparation method of a porous implant based on ceramic additive manufacturing

Abstract

The invention provides a preparation method of a porous implant based on ceramic additive manufacturing. The method comprises the following steps that a ceramic negative-type mold of a porous implant model with a gradient microstructure is prepared by using the additive manufacturing method; the ceramic mold is filled with metal powder through pressing of a press machine, a primary metal porous implant is obtained, and the primary metal porous implant is subjected to vacuum sintering so as to enhance the strength of the implant; a mixture of the implant and the ceramic mold is placed in a solution which can dissolve the ceramic mold, and an independent metal implant is obtained; a metal coating is deposited on the surface of the metal implant by using the chemical vapor deposition method; finally, a metal oxide nanotube structure is formed in the surface of the metal implant by using the anodic oxidation method. By means of the method, the defects that a traditional preparation method of the porous implant is uncontrollable in microstructure, direct laser additive manufacturing is high in difficulty and the equipment requirement is high are overcome, the nanocrystallization of the surface structure can be achieved, and a new approach for preparing the porous implant with macro- and micro-nano structures is explored.

Description

technical field [0001] The invention relates to a method for preparing a porous implant based on ceramic additive manufacturing. The method belongs to the field of biological additive manufacturing (3D printing) and can be applied to the field of biomedicine. Background technique [0002] Additive manufacturing has important applications in the medical field, especially for the manufacture of personalized implants, which has unparalleled advantages and a potential market of tens of billions in the future. At present, implants manufactured by direct metal forming of various metal materials such as stainless steel, titanium alloy and cobalt-based alloy have been widely used in heart valve stents, vascular stents, digestive tract stents, bone repair and replacement stents and other stents clinically, and achieved better therapeutic effect. However, the complex environment in the human body will cause material corrosion and release of toxic elements, resulting in the reduction ...

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the disadvantages of the uncontrollable microscopic gradient structure of the porous implant scaffold and the inability to form nanostructures, the object of the present invention is to provide a method for preparing a porous implant based on ceramic additive manufacturing, which combines additive manufacturing technology, The combination of powder metallurgy technology, chemical vapor deposition technology and anodic oxidation technology can realize the controllable formation of microscopic gradient structure, and form nanostructures to facilitate cell activities, improve the biocompatibility of porous implants, and it is expected to open up new possibilities for the preparation of porous scaffolds. pathway, which is of great significance for promoting the clinical application of porous implants