Chewable tablet with lipid alleviating effect and preparation method of chewable tablet

A chewable tablet and tablet-compressing technology, which is applied in the field of biotechnology and specialty medicine, to achieve the effect of convenient taking, advanced technology and stable dosage form

Inactive Publication Date: 2017-11-07
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although many literature reports have confirmed that various traditional Chinese medicines have the effect of lowering blood lipids, there is no report on making multiple Chinese medicinal materials into compound chewable tablets as a health food for preventing and treating hyperlipidemia

Method used

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  • Chewable tablet with lipid alleviating effect and preparation method of chewable tablet
  • Chewable tablet with lipid alleviating effect and preparation method of chewable tablet
  • Chewable tablet with lipid alleviating effect and preparation method of chewable tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A flat fat chewable tablet made of the following raw materials in weight percentage: wolfberry extract 26%, prickly pear extract 17%, fenugreek extract 13%, filler 42%, flavoring agent 1% and lubricant 1% The wolfberry extract, the fenugreek extract and the cactus extract are that the wolfberry, the fenugreek and the cactus are respectively added into water whose weight is 8 times, and the reflux is extracted for 2 hours, filtered, and the filter residue is removed, and the filtrate is concentrated under reduced pressure to obtain the soaked paste, dried and ground to obtain wolfberry extract, fenugreek extract and prickly pear extract respectively.

[0036] The lubricant is magnesium stearate, which has the characteristics of good fluidity and high compressibility.

[0037] The filler is mannitol.

[0038] The flavoring agent is stevioside. The present invention contains fenugreek, which has a bitter taste, and the flavoring agent is added to make it easy to chew and ...

Embodiment 2

[0043] A kind of preparation method of flat fat chewable tablet, concrete steps are as follows:

[0044] After mixing 4.0g of wolfberry extract, 4.0g of cactus extract and 1g of fenugreek extract evenly, add 9.95g of mannitol, 0.02g of stevioside, 0.78g of citric acid and 0.1g of mint essence, and mix evenly, using 85 % ethanol 4.5ml to make soft material, pass through a 14-mesh sieve to granulate, and dry at 50°C for 120min.

[0045] After drying, use a 14-mesh sieve to sieve the granules, add 0.15 g of magnesium stearate, mix well, put into a tablet machine to compress, pack, and obtain flat fat chewable tablets; store at room temperature at 20°C.

[0046] The wolfberry extract, the fenugreek extract and the cactus extract are that the wolfberry, the fenugreek and the cactus are respectively added in 60% ethanol whose volume concentration is 6 times of the weight, reflux extraction for 1 hour, filter, remove the filter residue, reduce Press and concentrate the filtrate to o...

Embodiment 3

[0048] A kind of preparation method of flat fat chewable tablet, concrete steps are as follows:

[0049] After mixing 7.8g of wolfberry extract, 2.0g of cactus extract and 3.9g of fenugreek extract, add 11.91g of mannitol, 0.01g of stevioside, 0.06g of citric acid and 0.06g of mint essence, and mix them evenly. Make soft material with 7ml of 75% ethanol, pass through a 14-mesh sieve to granulate, and dry at 50°C for 120min.

[0050] After drying, use a 14-mesh sieve to sieve the granules, add 0.26g of magnesium stearate, mix well, put into a tablet machine to compress, pack, and obtain flat fat chewable tablets; store at room temperature at 20°C.

[0051] The wolfberry extract, fenugreek extract and cactus extract are obtained by adding wolfberry, fenugreek and cactus into water 10 times its weight, refluxing and extracting for 3 hours, filtering, removing filter residue, and concentrating the filtrate under reduced pressure to obtain an extract , then dried and ground to obt...

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Abstract

The invention relates to a chewable tablet with a healthy lipid alleviating effect, and belongs to the technical field of biotechnologies and characteristic medicines. The chewable tablet with the lipid alleviating effect is prepared from raw materials with a preparation method as follows: 20%-30% of fructus lycii extract, 10%-20% of opuntia dillenii extract, 5%-15% of trigonella foenum-graecum seed extract, 0.5%-4.5% of a corrective and 35%-45% of filler are evenly mixed, a soft material is prepared, sieved, dried and pelletized, 0.5%-1% of a lubricant is added, a mixed material is stirred, mixed and subjected to tablet compressing, and the chewable tablet with the lipid alleviating effect is obtained. Health food with effects of preventing and treating hyperlipidemia is prepared from the three traditional Chinese medicine raw materials through combination and is not reported at home and abroad at present. The three traditional Chinese medicines are formulated in a scientific proportion based on traditional Chinese medicine theories, the extracts, the filler and the corrective of the traditional Chinese medicines are used for palletization and tablet compressing together, and the obtained chewable tablet has the hyperlipidemia alleviating effect.

Description

technical field [0001] The invention relates to chewable tablet technology, in particular to a chewable tablet with the health-care function of flat fat, and belongs to the technical field of biotechnology and characteristic medicine. Background technique [0002] Hyperlipidemia refers to abnormal fat metabolism or abnormal operation in the body, which causes plasma lipids to exceed normal values. A fatal disease caused by high cholesterol and cholesterol (TC). It is one of the main risk factors for inducing atherosclerosis, coronary atherosclerotic heart disease, and stroke. According to statistics, about 12 million people die of cardiovascular and cerebrovascular diseases in the world every year, and hyperlipidemia is one of the main causes of cardiovascular and cerebrovascular diseases. There are as many as 160 million hyperlipidemia patients in China, and the number of patients is increasing , seriously endangering the health of the population and the quality of life i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61K9/20A61P3/06A23L33/105
CPCA23L33/105A23V2002/00A61K9/0056A61K9/2018A61K36/33A61K36/48A61K36/815A61K2300/00A23V2250/21A23V2200/3262
Inventor 余建强张霞杨建宏李风梅陆敏马鹏生刘宁
Owner NINGXIA MEDICAL UNIV
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