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A kind of ciprofloxacin lactate injection and production method thereof

A technology of ciprofloxacin lactate and a production method, which is applied in directions such as pharmaceutical formulations, inorganic inactive ingredients, organic active ingredients, etc., can solve the problems of waste of resources, unqualified foreign objects, and flocculents of manufacturers, and achieve guaranteed product quality. The effect of quality, lower production cost and easy operation

Active Publication Date: 2020-06-30
BEIJING LISHIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after the products produced by the existing production process are stored for several months, flocs will appear, resulting in unqualified visible foreign matter, so that the user will return the product many times, which will not only cause a great waste of resources for the manufacturer, but also cause Cause adverse effects on customers and affect the company's reputation

Method used

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  • A kind of ciprofloxacin lactate injection and production method thereof
  • A kind of ciprofloxacin lactate injection and production method thereof
  • A kind of ciprofloxacin lactate injection and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] S1: Add water for injection of 70% of the pre-prepared volume into the preparation container, and start stirring;

[0048] S2: Weigh a predetermined amount of ciprofloxacin lactate and add it to the preparation container, the ratio of the ciprofloxacin lactate to the preparation volume is 5g / L;

[0049] S3: Add lactic acid, propylene glycol, sodium chloride, sodium bisulfite and disodium EDTA to the preparation container and dissolve them completely; wherein, the ratio of the added lactic acid to the volume of ciprofloxacin lactate injection is 2g / L , the ratio of the added propylene glycol to the volume of ciprofloxacin lactate injection is 200ml / L, the ratio of the added sodium chloride to the volume of ciprofloxacin lactate injection is 9g / L, the added sodium bisulfite and lactate cyclic The ratio of the volume of the profloxacin injection is 5g / L, and the ratio of the added disodium EDTA to the volume of the ciprofloxacin lactate injection is 0.5g / L;

[0050] S4: A...

Embodiment 2

[0058] S1: Add water for injection of 60% of the pre-prepared volume into the preparation container, and start stirring;

[0059] S2: Weigh a predetermined amount of ciprofloxacin lactate and add it to the preparation container, the ratio of the volume of ciprofloxacin lactate to ciprofloxacin lactate injection is 5g / L;

[0060] S3: Add lactic acid, propylene glycol, sodium chloride, sodium bisulfite and disodium EDTA to the preparation container and dissolve them completely; wherein, the ratio of the added lactic acid to the volume of ciprofloxacin lactate injection is 2g / L , the ratio of the added propylene glycol to the volume of ciprofloxacin lactate injection is 200ml / L, the ratio of the added sodium chloride to the volume of ciprofloxacin lactate injection is 9g / L, the added sodium bisulfite and lactate cyclic The ratio of the volume of the profloxacin injection is 2g / L, and the ratio of the added disodium EDTA to the volume of the ciprofloxacin lactate injection is 1g / L; ...

Embodiment 3

[0069] S1: Add water for injection of 60% of the pre-prepared volume into the preparation container, and start stirring;

[0070] S2: Weigh a predetermined amount of ciprofloxacin lactate and add it to the preparation container, the ratio of the volume of ciprofloxacin lactate to ciprofloxacin lactate injection is 5g / L;

[0071] S3: Add lactic acid, propylene glycol, sodium chloride, sodium bisulfite and disodium EDTA to the preparation container and dissolve them completely; wherein, the ratio of the added lactic acid to the volume of ciprofloxacin lactate injection is 2g / L , the ratio of the added propylene glycol and lactate ciprofloxacin injection volume is 300ml / L, the ratio of the added sodium chloride to lactate ciprofloxacin injection volume is 9g / L, the added sodium bisulfite and lactic acid cyclic Profloxacin injection volume ratio is 5g / L, and the ratio of added EDTA disodium and lactate ciprofloxacin injection volume ratio is 1g / L;

[0072] S4: Add water for injec...

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Abstract

The present invention relates to a ciprofloxacin lactate injection and a production method thereof. The method comprises: S1, adding water for injection to achieve 50-70% of a predetermined preparation volume; S2, weighing a predetermined amount of ciprofloxacin lactate, adding into a preparation container; S3, adding lactic acid, propylene glycol, sodium chloride, sodium bisulfite and disodium EDTA into the preparation container, and completely dissolving; S4, adding water for injection to achieve the predetermined volume, and adjusting the pH value; S5, adding active carbon for needle; S6, filtering and potting; and S7, sterilizing, and carrying out lamp inspection, wherein a volume ratio of the added propylene glycol to the ciprofloxacin lactate injection is 250-350 ml / L, a volume ratio of the added sodium bisulfate to the ciprofloxacin lactate injection is 1-5 g / L, and a volume ratio of the added disodium EDTA to the ciprofloxacin lactate injection is 0.3-1 g / L. According to the present invention, the ciprofloxacin lactate injection production method has advantages of operation step reducing, working time shortening, production cost reducing, and product quality ensuring.

Description

technical field [0001] The invention relates to the field of agricultural pharmacy, in particular to a ciprofloxacin lactate injection and a production method thereof. Background technique [0002] Ciprofloxacin Lactate Injection is a product listed in Announcement No. 1960 of the Ministry of Agriculture of the People's Republic of China and has been produced for many years. However, after the products produced by the existing production process are stored for several months, flocs will appear, resulting in unqualified visible foreign matter, so that the user will return the product many times, which will not only cause a great waste of resources for the manufacturer, but also cause Cause adverse effects to customers and affect the company's reputation. [0003] Therefore, the existing production method of ciprofloxacin lactate injection urgently needs to be improved. Contents of the invention [0004] For solving the deficiencies in the prior art, the invention provides...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/496A61K47/18A61K47/10A61K47/02
CPCA61K9/0019A61K9/08A61K31/496A61K47/02A61K47/10A61K47/183
Inventor 徐海鸥张殿奎薛磊方泰云
Owner BEIJING LISHIDA PHARMA