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Markers micro-RNA-769-5p for prognosis of non-small cell lung cancer and their use in drugs and diagnostic kit

A technology of non-small cell lung cancer and molecular markers, applied in the field of molecular biology, to achieve the effect of improving accuracy

Inactive Publication Date: 2017-12-05
唐山市人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Current clinicopathological staging has limitations in predicting brain metastases in patients

Method used

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  • Markers micro-RNA-769-5p for prognosis of non-small cell lung cancer and their use in drugs and diagnostic kit
  • Markers micro-RNA-769-5p for prognosis of non-small cell lung cancer and their use in drugs and diagnostic kit
  • Markers micro-RNA-769-5p for prognosis of non-small cell lung cancer and their use in drugs and diagnostic kit

Examples

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Embodiment Construction

[0039] The present invention will be further described below in conjunction with the accompanying drawings and embodiments, but the embodiments do not constitute any limitation to the present invention.

[0040] The experimental methods used in the following examples are conventional methods unless otherwise specified.

[0041] The materials and reagents used in the following examples can be obtained from commercial sources unless otherwise specified.

[0042]The experimental methods for the specific conditions not indicated in the examples are generally conventional methods in the art.

[0043] In this implementation, the methods for finding markers for metastasis, prognosis and targeted therapy of non-small cell lung cancer are as follows:

[0044] 1. Patients and Specimens:

[0045] From July 2004 to June 2009, 93 patients with paraffin wax specimens of non-small cell lung cancer confirmed by pathology after complete resection and who had not received radiotherapy, chemot...

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Abstract

The invention belongs to the technical field of molecular biology and discloses a group of molecular markers micro-RNA-769-5p for metastasis, prognosis or targeted therapy of non-small cell lung cancer. The invention further discloses a use of the molecular markers in preparation of a diagnostic reagent or kit for metastasis, prognosis or targeted therapy of the non-small cell lung cancer. The invention also discloses an application of the micro-RNA-769-5p in preparation of a drug for inhibiting the tumor and an application of the gene expression of the micro-RNA 769-5p in preparation of tumor inhibiting prognosis or targeting treatment drugs. The molecular markers can effectively carry out molecular level detection to judge the markers of metastasis, prognosis and targeted treatment on non-small cell lung cancer patients through a molecular biology technology, provides convenience for individual treatment on diseases and has an important guiding significance for the follow-up clinical research.

Description

technical field [0001] The invention belongs to the technical field of molecular biology, and in particular relates to a group of marker gene microRNA-769-5p as a non-small cell lung cancer diagnostic marker and its application in medicine and diagnostic kits. Background technique [0002] Lung cancer has always been one of the most dangerous malignant tumors, and its high morbidity and mortality are the main causes of cancer death in China and even in the world. According to the pathological type, lung cancer is mainly divided into two categories: one is small cell lung cancer, accounting for about 15% of lung cancer; the other is non-small cell lung cancer, accounting for about 85%. Although there has been some progress in lung cancer research, including early diagnosis of lung cancer patients, preoperative adjuvant chemotherapy, radiotherapy and even targeted therapy, the onset of lung cancer is hidden. Due to the timing of treatment and the lack of sensitive, specific, ...

Claims

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Application Information

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IPC IPC(8): A61K31/7105A61P35/00C12Q1/68C12N15/11
CPCA61K31/7105C12Q1/6886C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 孙国贵胡万宁
Owner 唐山市人民医院