Method for simple and rapid determination of six fatty acid ethyl esters in human whole blood

A technology for rapid determination of fatty acid ethyl esters, applied in measuring devices, instruments, scientific instruments, etc., can solve the problems that plasma or serum biological samples cannot be obtained, no whole blood analysis method has been seen, and the processing steps are cumbersome, etc., to achieve easy The effect of operation and promotion, high detection time requirements, and simple pretreatment process
CN107543869AActive Publication Date: 2018-01-05FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
FUDAN UNIV
Publication Date
2018-01-05

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Abstract

The invention relates to a method for simple and rapid determination of six fatty acid ethyl esters in human whole blood, belonging to the technical fields of drug detection and forensic identification, wherein the six fatty acid ethyl esters include ethyl myristate, ethyl palmitate, ethyl stearate, ethyl oleate, ethyl linoleate and ethyl arachidonate. The method is low in the usage amount of samples, and as few as 200 [mu]L of samples are examined. The process of pretreatment is simple and fast. A HP-5MS capillary gas chromatographic column and a mass spectrometric detector are employed for determination of the contents of the six fatty acid ethyl esters in human whole blood. The method has the advantages of high sensitivity, good specificity, a wide linear range, simple and fast operation and low usage amount of extraction solvents, and is capable of satisfying high requirements of urgent forensic identification tasks on detection time and easy to operate and promote.
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Description

technical field

[0001] The invention belongs to the technical field of drug detection and forensic identification, and particularly relates to a simple and rapid determination of 6 kinds of fatty acid ethyl esters (ethyl myristate, ethyl palmitate, ethyl stearate, ethyl oleate) in human whole blood ester, ethyl linoleate, ethyl arachidonic acid). Background technique

[0002] The data shows that the abuse of ethanol is very common in today's society, and has produced many adverse effects on the society. In the work of forensic identification, the detection of ethanol is of great significance for the investigation of the cause of traffic accidents and other cases and the determination of responsibility. However, in actual cases, due to the fast metabolism of ethanol, and sometimes ethanol may be produced in the process of corpse decay, the detection of ethanol in the samples cannot truly reflect the drinking situation. Studies have shown that fatty acid ethyl esters include...

Claims

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