A bismuth potassium citrate oral adhesive tablet and preparation method thereof
A technology of bismuth potassium citrate and adhesive tablets, which is applied in the direction of medical formulas, medical preparations containing active ingredients, medical preparations without active ingredients, etc., to achieve no adverse reactions and side effects, reduced doses, and high use compliance Effect
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Embodiment 1
[0025] Embodiment 1 Bismuth Potassium Citrate Oral Adhesive Tablets (100,000 pieces) of the present invention
[0026]
[0027]
[0028] Preparation Process:
[0029] (1) After passing the prescription amount of bismuth potassium citrate and dextrin through a 60-mesh sieve, set aside;
[0030] (2) Mix the sifted bismuth potassium citrate and dextrin for 15 minutes until evenly mixed to obtain mixed powder 1;
[0031] (3) the prescription amount of polyvinylpyrrolidone K30 Make a 2% solution with water as a binder; put the mixed powder 1 in a fluidized bed granulator and spray it into the binder to granulate, the powder is completely dried at 75°C, and the obtained granules are passed through a 20-mesh sieve for granulation , to obtain intermediate 1;
[0032] (4) The prescribed amount of carbomer 974P , sodium carboxymethyl starch, magnesium stearate, and micropowder silica gel were passed through an 80-mesh sieve, and mixed with Intermediate 1 for 15 minutes to obta...
Embodiment 2
[0036] Embodiment 2 Bismuth Potassium Citrate Oral Adhesive Tablets (100,000 pieces) of the present invention
[0037]
[0038] Preparation Process:
[0039] (1) After passing the prescription amount of bismuth potassium citrate through an 80 mesh sieve and starch through a 40 mesh sieve, set aside;
[0040] (2) Mix the sifted bismuth potassium citrate and starch for 15 minutes until they are evenly mixed to obtain mixed powder 1;
[0041] (3) the prescription amount of polyvinylpyrrolidone K30 Prepare a solution with purified water as a binder; put the mixed powder 1 in a fluidized bed granulator and spray the binder into granules, the powder is completely dried at 75°C, and the obtained granules are passed through a 20-mesh sieve for granulation to obtain Intermediate 1;
[0042] (4) The prescribed amount of carbomer 974P , sodium carboxymethyl starch, magnesium stearate, and micropowder silica gel are passed through an 80-mesh sieve, and placed in a planetary mixer w...
Embodiment 3
[0046] Embodiment 3 Bismuth Potassium Citrate Oral Adhesive Tablets (100,000 pieces) of the present invention
[0047]
[0048] Preparation Process:
[0049] (1) After passing the prescription amount of bismuth potassium citrate through an 80-mesh sieve and dextrin through a 60-mesh sieve, set aside;
[0050] (2) Mix the sifted bismuth potassium citrate and dextrin for 15 minutes until they are evenly mixed to obtain mixed powder 1;
[0051] (3) the prescription amount of polyvinylpyrrolidone K90 Use 75% ethanol to make a solution as a binder. Put the mixed powder 1 in a fluidized bed granulator and spray it with a binder for granulation. The powder is completely dried at 75°C, and the obtained granules are passed through a 20-mesh sieve for granulation to obtain intermediate 1;
[0052] (4) The prescribed amount of carbomer 974P , sodium carboxymethyl starch, magnesium stearate, and micropowder silica gel are passed through an 80-mesh sieve, and placed in a planetary m...
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