Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pulse-type administration preparation of anti-drug-resistant-bacteria antibiotic microspheres

A technology for antibiotics and drug-resistant bacteria, applied in the field of medicine, can solve the problems of not realizing simultaneous transmission of pulse drug delivery system, poor patient treatment compliance and side effects, etc., to improve bioavailability, large patient compliance, and small side effects. Effect

Active Publication Date: 2018-01-16
BEIJING YUEKANGKECHUANG PHARM TECH CO LTD
View PDF7 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Neither the above-mentioned nor the prior art realizes the pulsatile drug delivery system that simultaneously transmits a single drug or a drug combination, which makes the patient's treatment compliance poor and has relatively large side effects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pulse-type administration preparation of anti-drug-resistant-bacteria antibiotic microspheres
  • Pulse-type administration preparation of anti-drug-resistant-bacteria antibiotic microspheres
  • Pulse-type administration preparation of anti-drug-resistant-bacteria antibiotic microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Embodiment 1 Pulse-type administration preparation of tipipenem microspheres

[0063] prescription:

[0064] Immediate Release Portion Prescription:

[0065] Tipipenem 10%

[0066] Microcrystalline Cellulose 90%

[0067] Hydroxypropyl Cellulose 5%

[0068] Delayed 4 hour partial prescription:

[0069]

[0070] Delayed 8 hours partial prescription:

[0071]

[0072] Preparation method:

[0073] (1) Preparation of immediate release part:

[0074] (1.1) Pulverizing tipipenem ester and microcrystalline cellulose, the powder is sieved respectively through a 100-mesh sieve;

[0075] (1.2) Take the pulverized tipipenem ester and microcrystalline cellulose and add them to the wet granulator, the stirring speed is 800r / min, and the stirring time is 3min, so that the tipipenem ester and microcrystalline cellulose are mixed evenly, add The hydroxypropyl cellulose aqueous solution with a mass concentration of 5% is uniformly mixed in a wet granulator, the stirring spe...

Embodiment 2

[0089] Embodiment 2 The pulse type administration preparation of tipipenem microspheres

[0090] prescription:

[0091] Immediate Release Portion Prescription:

[0092] Tipipenem 10%

[0093] Microcrystalline Cellulose 90%

[0094] Hydroxypropyl Cellulose 5%

[0095] Delayed 4 hour partial prescription:

[0096]

[0097] Delayed 8 hours partial prescription:

[0098]

[0099] Preparation method: according to embodiment 1 preparation method.

Embodiment 3

[0100] Example 3 Prescription of pulse-administered formulations of tipipenem microspheres:

[0101] Immediate Release Portion Prescription:

[0102] Tipipenem 12%

[0103] Dextrin 85%

[0104] Hydroxypropyl Cellulose 5%

[0105] (2) Some prescriptions delayed for 4 hours:

[0106]

[0107] Delayed 8 hours partial prescription:

[0108]

[0109] Preparation method: according to embodiment 1 preparation method.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a pulse-type administration preparation of anti-drug-resistant-bacteria antibiotic microsphere, wherein the preparation comprises three parts capable of achieving pulse slow release in three times. The three parts include: a quick release part, which contains a main drug core microsphere; an N-hour delaying part, which contains a main drug core microsphere, an inner-layermixture coating, and an outer-layer enteric polymer coating; and a 2N-hour delaying part, which contains a main drug core microsphere, an inner-layer mixture coating, and an outer-layer enteric polymer coating, wherein N is a natural number in a range of 2-6. The main drug is anti-drug-resistant-bacteria antibiotics, which includes carbapenem antibiotics, aminoglycoside antibiotics, and polypeptide antibiotics. The preparation has a pulse-type administration system that ensures conveying of a single medicine or a medicine association at the same time and a controller of pulse-type administration time for efficiently treating diseases, and has maximum patient compliance and minimum side effect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pulse-type administration preparation of antibiotic microspheres against drug-resistant bacteria. Background technique [0002] Although the antibiotics currently used clinically are constantly being updated, starting from the first generation of penicillins, they have gradually developed to antibiotics commonly used in clinical practice, including β-lactams, aminoglycosides, macrolides, lincomycins, peptides, etc. Classes, quinolones, sulfonamides, antituberculosis drugs, antifungal drugs and other antibiotics. However, the abuse of antibiotics will lead to drug resistance (adaptability to drugs) of bacteria, that is to say, the same pathogenic bacteria may not be able to be cured when they are re-infected with this bacteria after using a certain antibiotic for many times. This disease necessitates the use of stronger antibiotics. In this way, it is possible to allow bacter...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/38A61K47/26A61K47/12A61K47/02A61K47/10A61K31/427A61P31/04
Inventor 陈闯葛彦杰于飞宋更申肖佳普
Owner BEIJING YUEKANGKECHUANG PHARM TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com