Traditional Chinese medicine composition for treating thrombocytopenia and its preparation method and application

A technology for thrombocytopenia and composition, which is applied in the directions of drug combination, pharmaceutical formulation, medical raw materials derived from mammals, etc., can solve the problems of blood transfusion reaction, patient intolerance, severe adverse reactions, etc. Drug utilization, high drug utilization effect

Active Publication Date: 2021-03-16
苏州红冠庄国药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many chemotherapy drugs (such as carboplatin, gemcitabine, mitomycin, cyclophosphamide, doxorubicin, etc.) can cause thrombocytopenia, combined chemotherapy is more likely to increase the incidence of thrombocytopenia, so thrombocytopenia caused by chemotherapy Symptoms greatly affect the progress of chemotherapy and the follow-up treatment of patients, and even affect the lives of patients
At present, Western medicine uses platelet transfusion as the standard treatment, but due to the limited storage time of platelets, lack of blood supply, high cost, and the possibility of blood-borne infections, blood transfusion reactions, and platelet antibody production, clinical application is limited; clinical drugs mainly It consists of adrenocortical hormone, immunosuppressant, etc., but the above-mentioned drugs have serious adverse reactions when used, and patients often cannot tolerate them; there are also biological types of drugs such as thrombopoietin (TPO) and IL-6, etc., although the curative effect is good and Few side effects, but its price is very expensive, ordinary consumers can not afford it, which limits the wide clinical application

Method used

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  • Traditional Chinese medicine composition for treating thrombocytopenia and its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take 6 parts by weight of deer blood and 1 part by weight of peanut clothing. The deer blood is inactivated by dry heat method, and then freeze-dried (pre-frozen at -35°C, and then heated to ≤40°C) to dryness, and the peanut clothing is added. Decoct with 6 times the amount of water twice, 1.5 hours each time, filter the decoction twice, combine the two filtrates and concentrate to obtain an extract-like peanut shell aqueous extract. Mix the deer blood and the obtained peanut shell water extract evenly to obtain a composition, add appropriate amount of pharmaceutical excipients lactose and microcrystalline cellulose and mix evenly, granulate with 50% ethanol and dry at an environment lower than 50°C, Then add an appropriate amount of magnesium stearate to mix evenly and perform tablet compression.

Embodiment 2

[0021] Take 4 parts by weight of deer blood and 1 part by weight of peanut clothes. The deer blood is inactivated by dry heat method, and then freeze-dried (pre-frozen at -30°C first, then heated to ≤40°C) until dry, and the peanut clothes are added. Decoct with 8 times the amount of water for 3 times, 1 hour each time, filter the three decoctions, combine the three filtrates and concentrate to obtain an extract-like peanut shell aqueous extract. The composition is obtained by uniformly mixing the deer blood and the obtained peanut skin aqueous extract, adding appropriate amount of pharmaceutical excipients lactose and microcrystalline cellulose, mixing uniformly, and granulating.

Embodiment 3

[0023] Take 10 parts by weight of deer blood and 1 part by weight of peanut clothing. The deer blood is inactivated by membrane filtration, and then freeze-dried (pre-frozen at -35°C first, then heated to ≤40°C) to dryness, and the peanut clothing is added. Decoct twice with 10 times the amount of water, 2 hours each time, filter the decoctions, combine the filtrates of the two decoctions and concentrate to obtain the water extract of peanut shells in the form of extract. Mix the deer blood and the obtained peanut shell water extract evenly to obtain a composition, add appropriate amount of pharmaceutical excipients lactose and microcrystalline cellulose and mix evenly, granulate with 50% ethanol and dry at an environment lower than 50°C, Then add an appropriate amount of magnesium stearate and silicon dioxide, mix evenly, and perform tablet compression. After tablet compression, use a common film coating solution for medicine to coat to obtain conventional tablets.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating thrombocytopenia and a preparation method and an application thereof. The traditional Chinese medicine composition is mainly prepared by mixing deer blood and peanut coat according to the weight ratio of (2-20):1. The deer blood is treated by the viral inactivation treatment and the freeze-drying treatment. In the treatment process, in order to guarantee that protein is not denaturalized because of the high temperature, the temperature does not exceed 50 DEG C, and in order to improve the utilization ration of drugs and the absorption rate by a human body, the liquid-state deer blood is made as the solid-state by using a freeze-drying mode. The peanut coat is concrete-like peanut coat aqueous extract obtained by boiling and concentrating the peanut coat and water, so the administration volume of the peanut coat is reduced by a hundred times through the processing, and medicinal compositions are not lost. The traditional Chinese medicine composition has the functions of tonifying deficiency and replenishing essence and blood, is capable of forming various dosage forms of the traditional Chinese medicinepreparations by adding other pharmaceutically acceptable accessory materials, and is used for treating the thrombocytopenia after chemotherapy without the side effect. In addition, the utilization ratio of the drug is high, and the preparation, administration and carriage are convenient.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and its preparation method and application, in particular to a traditional Chinese medicine composition for treating thrombocytopenia, its preparation method and application, and belongs to the field of traditional Chinese medicine pharmacy. Background technique [0002] Thrombocytopenia is a common disease in clinical hematology, and its etiology is often caused by radiotherapy, chemotherapy, or idiopathic thrombocytopenic purpura, among which chemotherapy is the main cause of thrombocytopenia. Thrombocytopenia after chemotherapy Symptoms such as dizziness, fatigue, fatigue, soreness of the waist and knees, and loss of appetite often occur in patients with dysentery. The reason for chemotherapy-induced thrombocytopenia is that chemotherapy is currently one of the effective methods for treating tumors. Due to the non-selective cell killing effect of anti-tumor drugs, chemotherapy damag...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/48A61P7/00A61P7/06A61P7/04A61K35/14
CPCA61K35/14A61K36/48A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 周翠霞杨彦鹏
Owner 苏州红冠庄国药股份有限公司
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