Lucid Ganoderma active component composition as well as preparation method and application thereof

Abstract

The invention relates to a lucid ganoderma active component composition as well as a preparation method and application thereof and belongs to the technical fields of traditional Chinese medicines andhealth-care food. The lucid ganoderma active component composition is prepared from polysaccharide, glycopeptides, ganoderic acid A, ganoderic acid B and ganoderic acid C2 according to the weight ratio of (5 to 55):(1.5 to 15):(1 to 8):(0.6 to 6):(0.5 to 5). The preparation method of the lucid ganoderma active component composition comprises the following steps: adding ethanol of 30 to 95 percent, which is 5 to 30 times relative to total weight of the raw materials into raw materials containing lucid ganoderma powder and broken spore lucid ganoderma powder; carrying out reflux extraction for1 to 3 times, with 1 to 8 hours each time; filtering, and recovering ethanol to obtain an ethanol extract; adding water which is 5 to 30 times that the total weight of the raw materials into extracteddregs, and extracting for 1 to 3 times, with 1 to 5 hours each time; filtering, and properly concentrating to obtain an aqueous extract; combining the ethanol extract with the aqueous extract to obtain the lucid ganoderma active component, wherein the weight ratio of the lucid ganoderma to the broken spore lucid ganoderma powder is (6 to 12) to (1 to 6). The lucid ganoderma active component composition disclosed by the invention has the effects of inhibiting chemotherapy-induced nausea and vomiting.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine and health food, in particular to a ganoderma lucidum active ingredient composition and its preparation method and application. Background technique [0002] In my country's long-standing treasure house of traditional Chinese herbal medicine, Ganoderma lucidum is well-known both at home and abroad for its medicinal value and its unique effects of nourishing and strengthening, strengthening the body and strengthening the body, and prolonging life. Ganoderma lucidum, also known as Ruicao, Wanniancao, etc., is a large medicinal fungus belonging to the genus Ganoderma of the Basidiomycota polyporaceae family, including Ganoderma lucidum (Levss.ex Fr.) Karst. and Ganoderma sinenseZhao.Xu et zhang The dry fruiting body of . It has the effects of invigorating the middle and Qi, nourishing yin and strengthening, strengthening the body, prolonging life, etc., and it has been listed as...

AI Technical Summary

Problems solved by technology

Frequent vomiting can lead to a large loss of digestive juice, water, electrolyte, and acid-base balance disorders, making the patient miserable, seriously affecting the patient's quality of life, not only affecting the curative effect, but even making the patient unbearable and interrupting the treatment

At present, the antiemetic drugs commonly used in clinic mainly include histamine (H 2 ), acetylcholine (M) and dopamine (DA) receptor antagonists and cannabinoids, etc., but these drugs have poor curative effect on post-chemotherapy vomiting, and have strong toxic and side effects, which are greatly limited in application

Newer antiemetics, such as NK 1 Antagonists and 5-HT 3 Receptor antagonist drugs are effective in antiemetic and antiemetic after chemotherapy, but they are expensive, have a narrow range of use, and have large toxic and side effects, so they often need to be combined in clinical practice