Lithospermum-erythrorhizon extract, preparation method and application thereof

A technology of extract and comfrey, applied in the field of medicine, to achieve the effect of lowering fasting blood sugar, preventing and treating diabetic neuropathy, and high yield

Pending Publication Date: 2018-02-23
湖南晓林生物科技发展有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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However, there is no drug that can ...

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  • Lithospermum-erythrorhizon extract, preparation method and application thereof
  • Lithospermum-erythrorhizon extract, preparation method and application thereof
  • Lithospermum-erythrorhizon extract, preparation method and application thereof

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preparation example Construction

[0060] Preparation of comfrey extract

[0061] The comfrey is dried at 55-65°C until the moisture content is below 0.5%, and the comfrey is ultra-finely pulverized into 80-120 mesh comfrey powder. Then weigh the comfrey powder (500Kg) into an extraction tank at room temperature; add 8 times the amount of distilled water; reflux extraction for 2 hours, extraction temperature 50℃, extraction liquid for 1 discharge of medicine residue, reflux extraction for 2 hours, and extraction liquid for 2 times of medicine residue , Reflux extraction for 2h, 3 times to discharge the slag, combine the extracts, let stand for 48 hours, and then pump the obtained mixture into the plate and frame filter press through a diaphragm pump (because the liquid is a solid-liquid mixture, it is not easy to be blocked Diaphragm pump), in order to make each batch of 500Kg of raw material extracted drug residue can be filtered through the plate and frame at a time, so consider choosing a plate and frame filter...

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Abstract

The invention discloses a comfrey extract, a preparation method and application thereof. After many years of hard work, the inventor discovered for the first time that comfrey extract and comfrey alkaloids can act on DNA chromosome complement (DNA base repair), and comfrey extract can strongly promote the uptake of glucose by liver cancer cell HepG2, and Both it and comfrey alkaloids have the effect of inhibiting aldose reductase. It shows that it has great potential in lowering blood sugar, treating diabetes and preventing and treating diabetic neuropathy. The comfrey extract and alkaloids of the present invention have the characteristics of rapid onset of action, short course of treatment, small side effects and the like in the treatment of diabetes. Moreover, the preparation method of the medicine of the present invention is convenient for large-scale production, and has important practical significance for the development of new enteric-coated oral preparations for treating diabetes.

Description

Technical field [0001] The present invention relates to the field of medicine, in particular to a comfrey extract and its preparation method and its application in the preparation of drugs for preventing and / or treating diabetes. Background technique [0002] Comfrey (scientific name: Lithospermum erythrorhizon Sieb.et Zucc.) is a perennial herbaceous plant belonging to the genus Comfrey in the Boraginaceae family. It is a traditional Chinese medicinal material and belongs to China's second-class protected plant. Comfrey is collected in the "Chinese Pharmacopoeia", and its medicinal source is the root of Comfrey. Excavated in spring and autumn, dried in the sun or slightly fired. Nature and flavor return to the meridian: sweet, salty, cold in nature, Guixin envelope, liver meridian, has the effects of cooling blood, promoting blood circulation, clearing heat, detoxifying and clearing rash, etc. It is a commonly used medicine for clearing heat, detoxification, and cooling blood t...

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Application Information

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IPC IPC(8): A61K36/30A61P3/10A61K31/715
CPCA61K36/30A61K31/715A61K2236/10A61K2236/331
Inventor 谢丹
Owner 湖南晓林生物科技发展有限公司
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