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Preparation method for medicinal composition for treating poliomyelitis

A composition and drug technology, applied in the field of preparation of pharmaceutical compositions, can solve the problems of complex preparation methods, time-consuming and laborious, low bioavailability, obvious side effects, etc., and achieve the effect of improving bioavailability, simple preparation method, and small side effects

Inactive Publication Date: 2018-03-09
周丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the medicines for the treatment of poliomyelitis in the market are single in effect, expensive, and have obvious side effects, and are more harmful to children. Therefore, it is urgent to research and develop a compound medicament for the treatment of poliomyelitis with good curative effect, low cost and little side effects. The preparation methods of polio drugs currently on the market are complex, time-consuming and labor-intensive, and the raw materials are easy to cause waste, and the bioavailability is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Party:

[0017] 48 parts of cocklebur, 55 parts of perilla, 15 parts of trichosanthes, 15 parts of Digupi, 10 parts of cassia, 2 parts of loquat leaves, 3 parts of alum, 2 parts of sodium carboxymethylcellulose, 1 part of dextrin, Glycine 1 part.

[0018] Preparation:

[0019] (1) Weigh the above raw materials according to the formula ratio, crush the dried cocklebur and perilla through a 100-mesh sieve, and then soak them in 70% ethanol for 1 hour. After all the ethanol volatilizes, add 2 times cocklebur The distilled water of weight of perilla and perilla is heated and boiled, filtered after cooling, and concentrate A is obtained after the filtrate is concentrated for subsequent use;

[0020] (2) Grind the trichosanthes, Digupi, Cassia, and loquat leaves after drying, pass through a 50-mesh sieve, add distilled water twice the total weight of the trichosanthes, Digupi, Cassia, and loquat leaves, heat to boil, and cool After filtering, the filtrate was concentrated ...

Embodiment 2

[0024] Party:

[0025] 65 parts of cocklebur, 70 parts of perilla, 25 parts of trichosanthes, 20 parts of Digupi, 15 parts of cassia, 4 parts of loquat leaves, 5 parts of alum, 2 parts of sodium carboxymethylcellulose, 1 part of dextrin, Glycine 1 part.

[0026] Preparation:

[0027] (1) Weigh the above raw materials according to the formula ratio, crush the dried cocklebur and perilla through a 120-mesh sieve, and then soak them in 80% ethanol for 3 hours. After all the ethanol volatilizes, add 4 times cocklebur The distilled water of weight of perilla and perilla is heated and boiled, filtered after cooling, and concentrate A is obtained after the filtrate is concentrated for subsequent use;

[0028] (2) Grind the trichosanthes, Digupi, Cassia, and loquat leaves after drying, pass through a 60-mesh sieve, add distilled water three times the total weight of the trichosanthes, Digupi, Cassia, and loquat leaves, heat to boil, and cool After filtering, the filtrate was concen...

Embodiment 3

[0032] Party:

[0033] 56 parts of cocklebur, 62 parts of perilla, 20 parts of trichosanthes, 18 parts of Digupi, 12 parts of cassia, 3 parts of loquat leaves, 4 parts of alum, 2 parts of mannitol, 1 part of dextrin, and 1 part of glycine.

[0034] Preparation:

[0035] (1) Weigh the above raw materials according to the formula ratio, crush the dried cocklebur and perilla through a 110-mesh sieve, and then soak them in 75% ethanol for 2 hours. After the ethanol is completely volatilized, add 3 times of cocklebur The distilled water of weight of perilla and perilla is heated and boiled, filtered after cooling, and concentrate A is obtained after the filtrate is concentrated for subsequent use;

[0036] (2) Grind TCS, Digupi, Cassia, and Loquat leaves after drying, pass through a 55-mesh sieve, add distilled water twice the total weight of TCM, Digupi, Cassia, and Loquat leaves, heat to boil, and cool After filtering, the filtrate was concentrated to obtain concentrate B for s...

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Abstract

The invention discloses a preparation method for a medicinal composition for treating poliomyelitis. The preparation method comprises the following steps: (1) preparing dried fructus xanthii and perilla nankinensis to obtain a concentrate A for later use; (2) preparing radix trichosanthis, cortex lycii radicis, semen cassiae torae and folium eriobotryae to obtain a concentrate B for later use; (3)mixing the concentrate A and the concentrate B, adding potassium alum to prepare a concentrate C; (4) preparing auxiliary materials which are added into the concentrate C into a clinically required finished product preparation. Compared with the prior art, the preparation method is simple; manpower and cost are reduced; raw materials can be utilized to the utmost extent; the bioavailability is improved; the medicinal composition for treating the poliomyelitis prepared by the method is good in treatment effect, low in cost and low in side effect, and has little harm to children.

Description

technical field [0001] The invention relates to a preparation method of a pharmaceutical composition, in particular to a preparation method of a pharmaceutical composition for treating polio. Background technique [0002] Polio generally refers to poliomyelitis. Poliomyelitis is an acute infectious disease caused by poliovirus that seriously endangers children's health. Poliovirus is a neurotropic virus that mainly invades the motor nerve cells of the central nervous system. Anterior horn motor neuron damage is dominant. Most of the patients are children aged 1 to 6. The main symptoms are fever, general discomfort, severe limb pain, and flaccid paralysis with irregular distribution and varying severity, commonly known as polio. The clinical manifestations of poliomyelitis are varied and include very mild nonspecific lesions, aseptic meningitis (nonparalytic poliomyelitis), and flaccid weakness of various muscle groups (paralytic poliomyelitis). In patients with poliomyelit...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61P31/14A61P25/00A61K33/06
CPCA61K33/06A61K36/21A61K36/28A61K36/428A61K36/482A61K36/535A61K36/73A61K36/815A61K2236/331A61K2300/00Y02A50/30
Inventor 周丽
Owner 周丽
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