36 results about "Poliomyelitis Infections" patented technology

The present invention relates to inactivated poliomyelitis vaccine and its preparation process, and is especially inactivated poliomyelitis vaccine prepared with attenuated poliomyelitis virus as initial strain. The present invention also relates to the method of preventing the testee from suffering from poliomyelitis.

The invention discloses a gene recombinant vaccine for preventing enterovirus 71 (EV71) infection and a preparation method thereof. The inflection comprises multiple diseases related with the nervous system such as hand-foot-and-mouth disease, paralytic diseases of sterile meningitis, cephalitis and poliomyelitis and the like. Escherichia coli labile enterotoxin B subunit (LTB) is used as an immunological enhancement adjuvant, two fragments of linear neutralizing epitope SP55 and SP70 in EV71 virus coat protein VP1 are used as antigens, prokaryotic expression plasmids of LTB-SP55-SP70 fusion genes are constructed by using gene engineering technology, the plasmids are expressed in escherichia coli, and a recombinant expression product is purified for preparing the EV71 virus gene engineering vaccine.

The invention belongs to the technical field of medicaments and relates to a method for purifying the general flavone resin of hollyhock dried flower which is a Chinese herbal medicament in Uyghur. Extract obtained through the backflow extraction with ethanol and the purification of macroporous resin comprises 50 to 90 weight percent of general flavone, wherein the flavone comprises the followingcomponents in percentage by weight: 15.0 to 45.0 percent of quercetin, 5.0 to 20.0 percent of kaempferol, 3.0 to 18 percent of astragaloside and the balance of the other flavonoid components. The general flavone extract of the hollyhock flower of the invention is used for preparing the medicaments for treating cough and asthma, detumescence, poliomyelitis, constipation, hemorrhoids, insomnia and amnesia.

An inactivated Polio Vaccine derived from Sabin strain for safe and effective immunization against Poliomyelitis is provided. A process of preparation for such vaccine and formulations thereof are also provided. Administration of the vaccine of the present invention along with other antigens provides immunization not only against polio infection but also against other pathogens causing Hepatitis C. Hepatitis D. Hepatitis E. Meningitis A. Meningitis B. Meningitis C. Meningitis W. Meningitis Y. Pnemococcal (23 valent or more). Smallpox, Typhoid, Bacille Calmette Guerin, Tuberculosis. Human Immunodeficiency Virus. Anthrax or the like, to which children or adults not immunized earlier are susceptible, particularly to which children are susceptible.

The invention discloses an external tincture for treating bone poliomyelitis and a preparation method of the external tincture. The external tincture comprises the following ingredients in parts by weight: 18-24 parts of radix aconiti, 18-24 parts of peach kernel, 18-24 parts of radix aconiti carmichaeli, 15-22 parts of dried tangerine or orange peel, 10-18 parts of folium artemisiae argyi, 18-25 parts of radix clematidis, 25-30 parts of semen brassicae, 10-15 parts of tuberculate speranskia herb, 10-20 parts of safflower carthamus, and 0.5-1.5 parts of musk. The external tincture in reasonable in compatibility of medicines, can treat various bone poliomyelitis effectively, such as cervical spondylopathy, scapulohumeral periarthritis, pain in waist and lower extremities, traumatic injury, sciatica, rheumatic arthritis, rheumatoid arthritis, hyperostosis, spinal stenosis, tenosynovitis, synovitis, gout, years of old injury, lumbar disc herniation, osteonecrosis of the femeral head, swelling, limp and numb, pain and the like caused by qi-stagnancy and blood stasis and blockage of meridians, is simple in formula, is good in osmotic effect, and is remarkable in treatment effect.

The invention provides a medicine for dispelling wind, dehumidifying, dredging channels and activating collaterals, which is composed of the following components in parts by weight: 7-10 parts of kadsura pepper stem, 7-10 parts of the root of kudzu vine, 6-9 parts of caulis sinomenii, 3-5 parts of fevervine, 6-9 parts of caulis spatholobi, 5-8 parts of garden balsam stem, 5-8 parts of drynaria rhizome, 6-9 parts of radix clematidis, 5-8 parts of cortex lycii radicis, 4-7 parts of clove, 13-18 parts of prepared sealwort, 4-7 parts of loranthus parasiticus, 4-7 parts of scorpio, 4-8 parts of stiff silkworm, 6-10 parts of pawpaw, and 13-18 parts of liquorice. A plurality of traditional Chinese medicine are matched rigorously, and therefore, the medicine for dispelling wind, dehumidifying, dredging channels and activating collaterals has the effects of eliminating evil and strengthening the body resistance, also has the effects of complementing the vital qi and improving body disease resistance while eliminating pathogenic factors, and is applied to patients suffering from wind, cold and dampness poliomyelitis, anaesthesia, cervical, scapulohumeral and four-limb ankylosis, dizziness, sleepiness, heavy body, muscle limp, fatigability and most of hemiplegia.

The invention provides a Sabin strain poliomyelitis type I virus monoclonal antibody and application thereof, and belongs to the field of immunology. The preparation method of the Sabin strain poliomyelitis type I virus monoclonal antibody comprises the following steps: carrying out immunization on mice with the Sabin strain poliomyelitis type I virus, mixing the mouse spleen cells with the mouse myeloma cells, screening and generating specific monoclonal antibody hybridoma cell strain resistaing against the Sabin strain poliomyelitis type I virus, and preserving the hybridoma cell strain with a preservation No. of CGMCC No.9231. The monoclonal antibody secreted by the hybridoma cell strain is high in valence, and has a large application prospect in diagnosis and treatment of poliomyelitis type I virus; meanwhile, the antibody can be used for specifically distinguishing poliomyelitis virus type I, type II and type III as well as other multiple enteroviruses to achieve good specificity; the Sabin strain poliomyelitis type I virus monoclonal antibody can be used for preparing an antigen content check kit for the poliomyelitis type I virus, and further used for identification and testing of the poliomyelitis type I virus, so that the Sabin strain poliomyelitis type I virus monoclonal antibody is wide in application prospect.

The invention discloses a Chinese herbal medicine composition for treating poliomyelitis and a preparation method of the Chinese herbal medicine composition. The Chinese herbal medicine composition is prepared from the following raw material medicines in parts by weight: 15-20 parts of astragalus membranaceus, 8-16 parts of Chinses angelica, 10-18 parts of roots of herbaceous peony, 6-12 parts of radix achyranthis bidentatae, 8-15 parts of cassia twigs, 9-17 parts of rhizomes of chuanxiong, 5-10 parts of hogfennel roots, 12-19 parts of radix codonopsis, 4-10 parts of licorice roots, 10-16 parts of common clubmoss herbs, 8-15 parts of suberect spatholobus stems, and 6-12 parts of honeysuckles. The Chinese herbal medicine composition disclosed by the invention has the beneficial effects that the selected materials are all natural traditional Chinese medicine materials which has no toxic or side effects, the Chinese herbal medicine composition has a good treating effect on the poliomyelitis, the poliomyelitis is not easy to recur, medicine resources are easy to obtain, and the prices are low.

The invention discloses a poliomyelitis sequela treatment medicine and a preparation method thereof. The medicine is mainly prepared from Aster tataricus, Radix Ophiopogonis, Radix Astragali, Radix Codonopsis, Chinese angelica root, white peony root, Chinese magnoliavine, licorice root, Gambir Plant, honeysuckle stem and scorpion according to a certain weight ratio. The medicine has blood circulation invigorating, muscle and tendon relaxing, wind dispelling, pain relieving, toxin draining and tissue regeneration promoting, and has the advantages of fast effectiveness, good treatment effect and no side effects in alleviation and treatment of poliomyelitis sequela.

The invention provides an immunogenic composition and belongs to the technical field of preparation of biological products. The immunogenic composition contains an inactivated poliomyelitis antigen and a type b haemophilus influenzae proteoglycan protein conjugate. The immunogenic composition can further contain a hepatitis b antigen and a physiologically acceptable carrier. The invention further provides a preparation method of the immunogenic composition. The immunogenic composition provided by the invention can be used for preventing infection of a plurality of types of pathogens at the same time; the antigens do not have a mutual interference phenomenon; the corresponding immunogenicity is not reduced when being compared with the immunogenicity excited by a single antigen; when the immunogenic composition provided by the invention is used, a vaccine inoculation program can be remarkably simplified, the inoculation efficiency is improved and the cost is reduced.

The invention discloses traditional Chinese medicine for treating poliomyelitis due to liver-kidney deficiency. The traditional Chinese medicine is characterized by being prepared from, by weight, 5 parts of Fructus lycii, 6 parts of Fructus ligustri lucidi, 9 parts of eclipta, 9 parts of pecan kernel, 6 parts of Orobanche yunnanensis, 5 parts of Fructus rubi, 6 parts of Phacellanthus tubiflorus, 6 parts of largeleaf dogwood bark, 9 parts of Polygonum chinense root, 9 parts of Caulis akebiae root, 6 parts of Fructus corni, 3 parts of Indo-Chinese rat snake, 6 parts of Fructus acanthopanacis, 6 parts of Morinda officinalis, 10 parts of Euonymus dielsianus, 15 parts of Flemingia philippinensis, 6 parts of garden balsam root, 10 parts of Briggsia fritschii, 10 parts of Ganltheria forrestii diels, 10 parts of Caryota ochlandra root and 4 parts of licorice root. Herbs in a formulation can cooperate with each other and generate synergistic effect and can jointly play a role in tonifying liver and kidney, strengthening tendons and bones and activating blood, and the traditional Chinese medicine can effectively treat poliomyelitis due to liver-kidney deficiency; using of the traditional Chinese medicine in many patients for several years shows that effective rate reaches 96.6%.

According to the embodiment, the invention discloses a bone bi-disease Lingxianwan (pills for treating bone bi-disease). The Lingxianwan consists of herba epimedii, rhizoma curcumae longae, frankincense, myrrh, radix paeoniae alba, rhizoma corydalis, radix notoginseng, rhizoma dioscoreae nipponicae, radix aucklandiae, flos carthami, radix curcumae, radix angelicae pubescentis, radix achyranthis bidentatae, radix gentianae macrophyllae, cassia twig, dragon's blood, semen strychni. According to the embodiment, the bone bi-disease Lingxianwan provided by the invention has the following effects: 1, dredging collateral and relieving pain: the Lingxianwan can be used for treating rheumatoid arthritis or contracture and numbness; 2, relieving swelling and eliminating stagnation: the Lingxianwan can be used for treating stasis, swelling and pain caused by trauma as well as swelling and pain caused by ulcer; and the Lingxianwan has a certain curative effect on various cancers; 3, the Lingxianwan is effective on treating sequela of poliomyelitis, protrusion of lumbar intervertebral disc, prosopalgia, rheumatoid arthritis, traumatic injury, blood stasis and pain, wind-cold-wetness type of arthralgia, joint contracture and numbness in whole body, cancer swelling and the like. The Lingxianwan is mainly used for treating throat bi-pain, ulcer swelling and toxin, wandering arthritis and pain,fracture, facial paralysis and myasthenia gravis.

The invention discloses a traditional Chinese medicine for treating poliomyelitis. The traditional Chinese medicine is prepared from the following medicinal materials in parts by weight: 25-35 parts of dendrobium nobile, 25-35 parts of Chinese Tallowtree root-bark, 15-25 parts of giant knotweed rhizomes, 20-30 parts of rhizomes of chuanxiong, 20-30 parts of Chinese wolfberry root-bark, 35-45 parts of tangerine seeds and 5-10 parts of licorice roots. The traditional Chinese medicine is prepared from pure traditional Chinese medicinal materials, adopts a scientific and reasonable formula, is easy to prepare, has no toxic or side effects, is short in curative effect, takes effect quickly and has effects of nourishing yin, clearing heat, cooling blood, promoting blood circulation, dispelling wind, relieving pain, tonifying the spleen and benefiting qi compared with conventional treatment principles for poliomyelitis.

Disclosed are novel indanone derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The indanone derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, flu, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.

The invention provides a medicine for treating poliomyelitis, belonging to the technical field of medicines, and aiming at treating poliomyelitis. The medicine is characterized by being prepared from the following traditional Chinese medicinal materials in parts by weight: 15 parts of radix clematidis, 12 parts of peach kernels, 13 parts of ramulus uncariae cum uncis, 6 parts of apricot kernels, 12 parts of honeysuckle flowers, 10 parts of radix remanniae, 10 parts of radix achyranthis bidentatae, 10 parts of silkworm excrement, 12 parts of poria cocos, 10 parts of rhizoma gastrodiae, 10 parts of radix astragali, 10 parts of radix angelica sinensis, 10 parts of radix ginseng, 10 parts of cortex phellodendri, 10 parts of rhizoma cibotii, 10 parts of semen cuscutae, 6 parts of flos carthami, 9 parts of earthworms, and 7 parts of licorice root. For the medicine for treating poliomyelitis, poliomyelitis is analyzed from the aspect of traditional Chinese medicine, at the early stage, poliomyelitis is caused by exogenous wind, damp and heat, at the later stage, the liver and the kidney are involved, consequently, quadriplegia is caused, the main causes of poliomyelitis are middle qi deficiency, wind-damp invasion, and phlegm accumulation and blood stasis, and in the aspect of treatment, the medicines with the efficacies of dispelling the wind and activating collaterals, clearing away heat and toxic materials, tonifying the liver and the kidney, and promoting blood circulation to remove blood stasis are mixed for treatment, and the effects are obvious.

The invention relates to a traditional Chinese medicine moxibustion stick, and belongs to the technical field of moxibustion. The traditional Chinese medicine moxibustion stick is specifically prepared from the following traditional Chinese medicine raw materials in parts by weight: 20-30 parts of daphne odera, 5-10 parts of Chinese eaglewood, 15-20 parts of eucommia bark, 20-25 parts of safflowers and 25-30 parts of radix notoginseng. The daphne odera, Chinese eaglewood, eucommia bark, safflowers and radix notoginseng are pulverized into powder and uniformly mixed, water is added to the powder mixture so the powder mixture is viscous, and then the mixture is pressed into cylinders and dried in the air. The traditional Chinese medicine moxibustion stick has the effects of connecting ligaments and dredging collaterals, promoting blood circulation and removing blood stasis, relieving adhesion and eliminating nodules, and has good therapeutic effects on diseases such as scapulohumeral periarthritis, lumbar muscle strain, poliomyelitis, muscle atrophy, sequelae of knife and gunshot wounds, chilblain, dysmenorrhea, facial paralysis and the like.

The invention discloses a medicine for treating poliomyelitis and a preparation method of the medicine. The medicine is mainly prepared from angelica sinensis, astragalus membranaceus, teasel root, radix achyranthis bidentatae, herba cistanche, radix isatidis, herba epimedii, poria cocos, bombyx batryticatus, honeysuckle, lycopodium clavatum, periostracum cicada, cortex acanthopanacis, eucommia ulmoides, cassia twig, morinda officinalis, semen cuscutae, fructus cannabis, bunge cherry seed, polygonum multiflorum, rhizoma cibotii, and Chinese starjasmine stem at certain weight proportion. The medicine has the functions of reinforcing the liver and kidney, tonifying the spleen and lung, relaxing the muscles, stimulating the blood circulation, replenishing blood and tonifying blood, takes effects quickly and has good treatment effects when being used to treat poliomyelitis, and does not cause relapse.

The invention relates to the technical field of biomedical science, in particular to a new target for resisting enterovirus 71 type infection, and an application. Human colon cancer cells (Caco-2) areused as target cells, an RNA interference technique is adopted for reducing expression of a target cell membrane receptor, a host factor which can effectively restrain EV71 infected human colon cancer cells is sought, and the purpose of blocking EV71 infection from a source (intestinal tract) is achieved. Through experiment, the inventor of the invention finds that the fibroblast growth factor receptor 1 (FGFR1) exerts important effects in EV71 infected Caco-2 cells, so that when the expression of the FGFR1 is reduced, the EV71 infection can be obviously restrained. The invention provides anapplication of the FGFR1 to preparation of medicines for preventing or treating enterovirus 71 type infection, and a new target and a treatment scheme are provided for clinical prevention and treatment of diseases of hand-foot-mouth diseases, meningitis, brainstem encephalitis or poliomyelitis and the like caused by the EV71 infection.

The invention belongs to the field of traditional Chinese medicines and in particular relates to a traditional Chinese medicine pill for treating poliomyelitis and a preparation method thereof. The traditional Chinese medicine pill is prepared from the following raw materials in parts by weight: 10-16 parts of divaricate saposhnikovia root, 10-13 parts of hairy antler, 2-5 parts of common clubmoss herb, 10-20 parts of Indian buead, 10-20 parts of Danshen root and 12-15 parts of clematis root. The preparation method comprises the following steps: mixing the raw materials in parts by weight uniformly, then washing the mixture cleanly and airing the mixture at 40 DEG C, then heating the mixture at 150 DEG C for 20 minutes and grinding the mixture into 20-mesh powder and mixing the obtained powder with dextrin according to a weight ratio of 1 to 2 to prepare a pill, thus obtaining the traditional Chinese medicine pill. The traditional Chinese medicine pill is simple in formula and reasonable and effective in component matching, has good treatment effects and has the functions of enhancing the physiques of patients, improving the immunities of the patients and radically curing poliomyelitis.

The invention discloses a medicinal composition for treating poliomyelitis. The medicinal composition for treating the poliomyelitis is mainly prepared from the raw materials in parts by weight: 48 to65 parts of fructus xanthii, 55 to 70 parts of perilla nankinensis, 15 to 25 parts of radix trichosanthis, 15 to 20 parts of cortex lycii radicis, 10 to 15 parts of semen cassiae torae, 2 to 4 partsof folium eriobotryae and 3 to 5 parts of potassium alum. Compared with the prior art, the medicinal composition can effectively treat poliomyelitis, and is low in cost, low in side effect, and has little harm to children; meanwhile, a preparation method is simple; manpower and cost are reduced; raw materials can be utilized to the utmost extent; the bioavailability is improved.

The invention belongs to the field of traditional Chinese medicines and in particular relates to traditional Chinese medicine powder for treating poliomyelitis and a preparation method thereof. The traditional Chinese medicine powder is prepared from the following raw materials in parts by weight: 10-15 parts of cassia twig, 20-25 parts of processed kusnezoff monkshood root, 10-15 parts of stem of sargentgloryvine, 10-25 parts of herb of Sievers wormwood and 10-20 parts of pinellia tuber. The preparation method comprises the following steps: mixing the raw materials in parts by weight uniformly and then grinding the mixture until the grain size is 100 meshes and heating the powder at 60 DEG C for two hours, thus obtaining the traditional Chinese medicine powder. The traditional Chinese medicine powder is simple in formula and reasonable and effective in component matching, has good treatment effects and has the functions of enhancing the physiques of patients, improving the immunities of the patients and radically curing poliomyelitis.

The invention relates to a swelling diminishing and pain relieving composition, application of the swelling diminishing and pain relieving composition, medicine liquid and a preparation method thereof. The composition is prepared from the following ingredients in parts by weight: 20 to 100 parts of japanese tripterospermum herb, 10 to 50 parts of clematis henryi, 10 to 50 parts of short-pedicel aconite roots, 20 to 100 parts of ophioglossum pedunculosum, 20 to 100 parts of oligocarpa roots and 10 to 50 parts of paris polyphylla. The composition has good swelling diminishing and pain relievingeffects. The medicine liquid prepared from the composition provided by the invention has a good treatment effect on ecchymoma and pain due to traumatic injury; meanwhile, the medicine liquid can alsobe used for the treatment on various open wounds, bleeding, rheumatism poliomyelitis, scapulohumeral periarthritis, cervical spondylosis, neck and waist red swelling hot and pain due to lumbar vertebra diseases, limb joint pain, limb joint pain, hand and foot numbness, ischioneuralgia and the like.

The invention discloses a preparation method for a medicinal composition for treating poliomyelitis. The preparation method comprises the following steps: (1) preparing dried fructus xanthii and perilla nankinensis to obtain a concentrate A for later use; (2) preparing radix trichosanthis, cortex lycii radicis, semen cassiae torae and folium eriobotryae to obtain a concentrate B for later use; (3)mixing the concentrate A and the concentrate B, adding potassium alum to prepare a concentrate C; (4) preparing auxiliary materials which are added into the concentrate C into a clinically required finished product preparation. Compared with the prior art, the preparation method is simple; manpower and cost are reduced; raw materials can be utilized to the utmost extent; the bioavailability is improved; the medicinal composition for treating the poliomyelitis prepared by the method is good in treatment effect, low in cost and low in side effect, and has little harm to children.

The invention belongs to the field of traditional Chinese medicines and in particular relates to a traditional Chinese medicine composition for treating poliomyelitis and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-15 parts of white silkworm, 20-25 parts of rehmannia root, 10-13 parts of weeping forsythia capsule, 10-12 parts of platycladi seed, 1-3 parts of borneol and 10-15 parts of Chinese angelica. The preparation method comprises the following steps: mixing the raw materials in parts by weight uniformly, then heating the mixture at 200 DEG C for one hour, then grinding the mixture until the grain size is 20 meshes and preparing a pill, thus obtaining the traditional Chinese medicine composition. The traditional Chinese medicine composition is simple in formula and reasonable and effective in component matching, has good treatment effects and has the functions of enhancing the physiques of patients, improving the immunities of the patients and radically curing poliomyelitis.

The invention belongs to the field of traditional Chinese medicines and in particular relates to a traditional Chinese medicine preparation for treating poliomyelitis and a preparation method thereof. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 10-20 parts of slenderstyle acanthopanax bark, 10-15 parts of leech, 10-20 parts of scorpion, 10-20 parts of centipede, 10-12 parts of radix notoginseng and 2-6 parts of divaricate saposhnikovia root. The preparation method comprises the following steps: mixing the raw materials in parts by weight uniformly and then grinding the mixture until the grain size is 40 meshes, heating the powder at 100 DEG C for five hours and then preparing a pill, thus obtaining the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is simple in formula and reasonable and effective in component matching, has good treatment effects and has the functions of enhancing the physiques of patients, improving the immunities of the patients and radically curing poliomyelitis.