Hydroxyethyl starch injection composition as well as preparation method and application of hydroxyethyl starch injection composition

A technology of hydroxyethyl starch and injection, applied in the field of injection, can solve problems such as interference with test results, and achieve the effect of reducing acidosis

Inactive Publication Date: 2018-03-16
HARBIN ZHENBAO PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But Ringer's Acetate still has some drawbacks: Intravenous infusion of Ringer's Acetate can interfere with ELISA test results for invasive aspergillosis

Method used

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  • Hydroxyethyl starch injection composition as well as preparation method and application of hydroxyethyl starch injection composition
  • Hydroxyethyl starch injection composition as well as preparation method and application of hydroxyethyl starch injection composition
  • Hydroxyethyl starch injection composition as well as preparation method and application of hydroxyethyl starch injection composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] This embodiment is a hydroxyethyl starch injection composition, which consists of the following components in parts by weight:

[0063]

[0064] pH 6.0

[0065] The preparation method of the electrolyte injection specifically includes: taking water for injection, dissolving each component in the water for injection according to the ratio, stirring to fully dissolve, adding water for injection, adjusting the pH value, and sterilizing and filling.

Embodiment 2

[0067] This embodiment is a hydroxyethyl starch injection composition, which consists of the following components in parts by weight:

[0068]

[0069] pH 5.5

[0070] The preparation method of the electrolyte injection specifically includes: taking water for injection, dissolving each component in the water for injection according to the ratio, stirring to fully dissolve, adding water for injection, adjusting the pH value, and sterilizing and filling.

Embodiment 3

[0072] This embodiment is a hydroxyethyl starch injection composition, which consists of the following components in parts by weight:

[0073]

[0074] pH 6.5

[0075] The preparation method of the electrolyte injection specifically includes: taking water for injection, dissolving each component in the water for injection according to the ratio, stirring to fully dissolve, adding water for injection, adjusting the pH value, and sterilizing and filling.

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Abstract

The invention relates to a hydroxyethyl starch injection composition as well as a preparation method and an application of the hydroxyethyl starch injection composition. The hydroxyethyl starch injection composition takes injection water as a solvent and comprises the following components: 10-130 g / L of hydroxyethyl starch, 6-12 g / L of malate ion, 1.5-5 g / L of sodium ion, 0.1-0.3 g / L of potassiumion, 0.01-0.07 g / L of magnesium ion, 0.03-0.2 g / L of calcium ion, and 2.0-6.44 g / L of chloride ion. The malic acid and the hydroxyethyl starch are compatible and used, the buffering effect is achieved, the pH value is also regulated, the hyperchloremic metabolic acidosis is reduced, and the various diseases such as the multi-symptom liver disease, anemia, hypoimmunity, uremia, hypertension, and hepatic failure can also be treated.

Description

technical field [0001] The invention relates to an injection, in particular to a hydroxyethyl starch injection composition containing hydroxyethyl starch and malic acid, a preparation method and application thereof. Background technique [0002] Hypovolemic shock refers to the pathophysiological process of effective circulating blood volume and cardiac output reduction, tissue hypoperfusion, cell metabolism disorder and functional impairment caused by loss of circulation volume caused by various reasons, such as surgical blood loss and trauma. . Early diagnosis, early fluid resuscitation, hypovolemic shock can often get better resuscitation effect. Giving colloids or crystalloids (ie, fluid therapy) to patients who have lost blood can reduce or avoid blood transfusions. Plasma, albumin, crystalloids, and artificial colloids are commonly used for fluid resuscitation. Compared with blood plasma, albumin and crystalloid, artificial colloid has the advantages of low cost and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/718A61K31/194A61P7/08
CPCA61K9/0019A61K9/08A61K31/194A61K31/718A61K2300/00
Inventor 方同华许照芹项彦华高丽
Owner HARBIN ZHENBAO PHARMA
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