Pharmaceutical composition for treating insomnia and application thereof

A composition and drug technology, applied in the field of medicine, can solve the problems of patients prone to drug resistance and poor drug efficacy, and achieve the effect of reducing clinical dosage and overcoming poor curative effect

Inactive Publication Date: 2018-03-20
GUILIN HAOXIN TECH SERVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of insomnia mainly focuses on the use of sleep aids, but the efficacy of a single sleep aid is poor, and patients are prone to drug resistance, so there is an urgent need to explore new pharmaceutical preparations for the treatment of insomnia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation of embodiment 1 pharmaceutical tablet of the present invention

[0016] Prescription: 5 parts by weight of fluazepam, 8 parts by weight of chlorpromazine, 10 parts by weight of phenobarbital, 80 parts by weight of lactose, 20 parts by weight of microcrystalline cellulose, 4 parts by weight of sodium carboxymethyl starch, 20 mL of ethanol, stearin Magnesium acid 1 weight part;

[0017] Preparation method: mix the prescribed amount of fluazepam, chlorpromazine, phenobarbital, lactose, microcrystalline cellulose, and sodium carboxymethyl starch in a granulator, add soft materials made of ethanol, and dry in vacuum. Sieve and granulate, then add magnesium stearate, mix evenly, and press into tablets.

Embodiment 2

[0018] The preparation of embodiment 2 pharmaceutical capsules of the present invention

[0019] Prescription: 3 parts by weight of fluazepam, 3 parts by weight of chlorpromazine, 5 parts by weight of phenobarbital, 80 parts by weight of lactose, and 1 part by weight of magnesium stearate;

[0020] Preparation method: mix and sieve the prescribed amount of fluazepam, chlorpromazine, phenobarbital, lactose, and magnesium stearate, and fill them into empty capsules.

Embodiment 3

[0021] The preparation of embodiment 3 pharmaceutical granules of the present invention

[0022] Prescription: 10 parts by weight of fluazepam, 15 parts by weight of chlorpromazine, 20 parts by weight of phenobarbital, 80 parts by weight of lactose, 20 parts by weight of microcrystalline cellulose, 4 parts by weight of sodium carboxymethyl starch, 20 mL of ethanol;

[0023] Preparation method: mix the prescribed amount of fluazepam, chlorpromazine, phenobarbital, lactose, microcrystalline cellulose, and sodium carboxymethyl starch in a granulator, add soft materials made of ethanol, and vacuum dry , sieve whole grains, and pack them into bags.

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PUM

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Abstract

The invention relates to a pharmaceutical composition for treating insomnia. The active ingredients of the composition comprise fludiazepam, chlorpromazine and Phenobarbital. The fludiazepam, chlorpromazine and Phenobarbital are combined to be used for treating the insomnia. The defects that the curative effect of single medication is poor and drug dependence of a patient is easily produced are overcome. The three medicines are combined to achieve a synergistic effect of enhancing insomnia resistance, and the clinical dosage of one or two medicines can be reduced, so that the toxicity reducingeffect is achieved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating insomnia and its application. Background technique [0002] Insomnia is the inability to fall asleep or stay asleep, resulting in a lack of sleep. Also known as sleep and sleep maintenance disorders, it is a common disease caused by various reasons such as difficulty in falling asleep, too short sleep depth or frequency, early awakening and insufficient sleep time or poor quality. Although insomnia is not a critical disease, it often affects the quality of life and hinders people's work, study and health. Long-term insomnia has brought great suffering to people and has become a public health problem more and more. [0003] Today, with the accelerated pace of society and intensified competition, the incidence of insomnia patients continues to rise. Insomnia has become a ubiquitous phenomenon and has become a hot research topi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5415A61K31/515A61K31/5513A61P25/20
CPCA61K31/5415A61K31/515A61K31/5513A61K2300/00
Inventor 钟传新王君
Owner GUILIN HAOXIN TECH SERVICE
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