Pharmaceutical composition for effectively improving sleep quality and use of pharmaceutical composition

A technology for sleep quality and composition, applied in the field of medicine, can solve the problems of poor drug efficacy and easy generation of drug resistance in patients, and achieve the effects of overcoming poor efficacy, synergistically enhancing anti-insomnia, and reducing clinical dosage.

Inactive Publication Date: 2018-01-19
GUILIN HAOXIN TECH SERVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of insomnia mainly focuses on the use of sleep aids, but the efficacy of a single sleep aid is poor, and patients are prone to drug resistance, so there is an urgent need to explore new pharmaceutical preparations for the treatment of insomnia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The preparation of embodiment 1 pharmaceutical tablet of the present invention

[0015] Prescription: 15 parts by weight of gaboxadol, 13 parts by weight of secobarbital, 20 parts by weight of trazodone, 80 parts by weight of lactose, 20 parts by weight of microcrystalline cellulose, 4 parts by weight of sodium carboxymethyl starch, 20 mL of ethanol, 1 part by weight of magnesium stearate;

[0016] Preparation method: Mix the prescribed amount of gaboxadol, secobarbital, trazodone, lactose, microcrystalline cellulose, and sodium carboxymethyl starch in a granulator, add ethanol-made soft material, and vacuum dry Finally, sieve and granulate, then add magnesium stearate, mix evenly, and then compress into tablets.

Embodiment 2

[0017] The preparation of embodiment 2 pharmaceutical capsules of the present invention

[0018] Prescription: 6 parts by weight of gaboxadol, 8 parts by weight of secobarbital, 5 parts by weight of trazodone, 80 parts by weight of lactose, and 1 part by weight of magnesium stearate;

[0019] Preparation method: mix and sieve the prescribed amount of gaboxadol, secobarbital, trazodone, lactose and magnesium stearate, and fill into empty capsules to obtain.

Embodiment 3

[0020] The preparation of embodiment 3 pharmaceutical granules of the present invention

[0021] Prescription: 20 parts by weight of gaboxadol, 25 parts by weight of secobarbital, 25 parts by weight of trazodone, 80 parts by weight of lactose, 20 parts by weight of microcrystalline cellulose, 4 parts by weight of sodium carboxymethyl starch, 20 mL of ethanol;

[0022] Preparation method: Mix the prescribed amount of gaboxadol, secobarbital, trazodone, lactose, microcrystalline cellulose, and sodium carboxymethyl starch in a granulator, then add soft materials made of ethanol, vacuum After drying, sieve and granulate, and pack into bags.

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PUM

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Abstract

The invention relates to a pharmaceutical composition for effectively improving the sleep quality and use of the pharmaceutical composition. The pharmaceutical composition contains the following effective components: gaboxadol, secobarbital and trazodone. According to the invention, gaboxadol, secobarbital and trazodone are combined for treating anhypnia, so that the defects that a single drug ispoor in treatment effect and drug dependence is easily generated by patients are overcome, the cooperatively reinforced insomnia resistance is achieved by virtue of the combination of three drugs, andan attenuation effect can be achieved by reducing the clinical dose of one or two drugs.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for effectively improving sleep quality and its application. Background technique [0002] Insomnia is the inability to fall asleep or stay asleep, resulting in a lack of sleep. Also known as sleep and sleep maintenance disorders, it is a common disease caused by various reasons such as difficulty in falling asleep, too short sleep depth or frequency, early awakening and insufficient sleep time or poor quality. Although insomnia is not a critical disease, it often affects the quality of life and hinders people's work, study and health. Long-term insomnia has brought great suffering to people and has become a public health problem more and more. [0003] Today, with the accelerated pace of society and intensified competition, the incidence of insomnia patients continues to rise. Insomnia has become a ubiquitous phenomenon and has become a...

Claims

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Application Information

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IPC IPC(8): A61K31/515A61K31/496A61K31/437A61P25/20
Inventor 钟传新王君
Owner GUILIN HAOXIN TECH SERVICE
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