Ultrasonic reflux extraction process of artemisinin

Abstract

The invention relates to an ultrasonic reflux extraction process of artemisinin. The process comprises the following steps of 1, material mixing, wherein artemisia apiacea leaves are naturally dried,the dried artemisia apiacea leaves are put into a reflux extractor provided with an ultrasonic oscillator, and petroleum ether with a boiling range specification of 95 DEG C is added; 2, extraction, wherein after artemisia apiacea residues are filtered, an extraction solution mainly containing artemisinin, plant wax, volatile oil, and artemisinic acid is obtained; 3, collection, wherein after a mixed solution of petroleum ether and ethyl acetate with the volume ratio of 92% is adopted for gradient elution, a flow part containing artemisinin is obtained; 4, drying, wherein the flow part containing artemisinin is subjected to vacuum decompression concentration and concentrated till the volume ratio of the flow part is 1 / 100-1 / 200; 5, crystallization, wherein an artemisinin crude product is added into 95% alcohol the weight of which is 60-80 times of that of the artemisinin crude product for dissolution, after filtration, a filtrate is placed into a concentration tank for concentration, and artemisinin crystals are obtained after filtration and dried at 80-85 DEG C for 4-6 hours to obtain an artemisinin fine product. In short, the process has the advantages that the preparation process is simple, the purification efficiency is high, and the preparation cost is low.

Description

technical field [0001] The invention belongs to the artemisinin preparation technology field, and in particular relates to an artemisinin ultrasonic reflux extraction process. Background technique [0002] Artemisinin is a colorless needle-like crystal extracted from the leaves of the compound inflorescence plant Artemisia annua, which is the traditional Chinese medicine Artemisia annua. Its stem does not contain the drug Artemisia annua. The most effective antimalarial drugs after that, especially for cerebral malaria and anti-chloroquine malaria, have the characteristics of quick action and low toxicity, and were once called "the only effective malaria treatment drug in the world" by the World Health Organization; antimalarial effect The mechanism mainly lies in the generation of free radicals through the activation of artemisinin during the treatment of malaria. The free radicals combine with malaria protein and act on the membrane structure of Plasmodium, destroying the ...

AI Technical Summary

Problems solved by technology

[0002] Artemisinin is a colorless needle-like crystal extracted from the leaves of the compound inflorescence plant Artemisia annua, which is the traditional Chinese medicine Artemisia annua. Its stem does not contain the drug Artemisia annua. The most effective antimalarial drugs after that, especially for cerebral malaria and anti-chloroquine malaria, have the characteristics of quick action and low toxicity, and were once called "the only effective malaria treatment drug in the world" by the World Health Organization; antimalarial effect The mechanism mainly lies in the generation of free radicals through the activation of artemisinin during the treatment of malaria. The free radicals combine with malaria protein and act on the membrane structure of Plasmodium, destroying the vesicular membrane, nuclear membrane and plasma membrane, and the mitochondria Swelling, inner and outer membranes fall off, thereby destroying the cell structure and function of Plasmodium; in addition, artemisinin also shows attractive prospects in the treatment of other diseases; such as anti-schistosomiasis, regulating or inhibiting the immune function of humoral, improving The conversion rate of lymphocytes, choleretic, expectorant, antitussive, antiasthma, etc., so artemisinin has great medical market prospects; and the current artemisinin preparation method has a low degree of automation, and it is difficult to operate. The operating procedures are also relatively complicated, so it is necessary to improve the extraction and preparation process of artemisinin