Veterinary five-flavored evergreen particle preparation method

A granule and five-flavor technology, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of difficult control of product quality, poor oxidation and stability, and obvious smell of volatile oil, etc., to achieve Good inclusion effect, improve utilization rate, cover the effect of volatile oil smell

Inactive Publication Date: 2018-04-27
BAODING JIZHONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the volatile oil is easy to volatilize, oxidize and have poor stability, the traditional Chinese medicine granule preparation process, the volatile

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A preparation method for veterinary Wuwei Changqing granules, comprising the following steps:

[0039] Step 1. Extract volatile oil:

[0040] First, after mixing Artemisia annua and Bupleurum, add water to it according to the volume ratio of material to liquid 1:9, reflux extraction at 100°C for 2 hours, collect volatile oil with a volatile oil collector, and obtain extract A, the extract of Artemisia annua and Bupleurum Medicine dregs, spare;

[0041] Step 2, preparation of volatile oil inclusion particles

[0042] Step 2-1, according to the mass ratio of volatile oil and glycerol of 1:25, add glycerol to the volatile oil collected in step 1, and mix evenly to obtain a volatile oil glycerin mixture;

[0043] Step 2-2, then according to the mass volume ratio of β-cyclodextrin to water: 1g: 6mL, add water to β-cyclodextrin, heat and dissolve in a boiling water bath to make β-cyclodextrin aqueous solution;

[0044] Step 2-3. According to the mass volume ratio of β-cycl...

Embodiment 2

[0054] A preparation method for veterinary Wuwei Changqing granules, comprising the following steps:

[0055] Step 1. Extract volatile oil:

[0056] First, after mixing Artemisia annua and Bupleurum, add water to it according to the volume ratio of material to liquid 1:10, reflux extraction at 100°C for 3 hours, collect volatile oil with a volatile oil collector, and obtain extract A, the extract of Artemisia annua and Bupleurum Medicine dregs, spare;

[0057] Step 2, preparation of volatile oil inclusion particles

[0058] Step 2-1, according to the mass ratio of volatile oil and glycerol of 1:28, add glycerol to the volatile oil collected in step 1, and mix evenly to obtain a volatile oil glycerin mixture;

[0059] Step 2-2, then according to the mass volume ratio of β-cyclodextrin to water: 1g: 7mL, add water to β-cyclodextrin, heat and dissolve in a boiling water bath to make β-cyclodextrin aqueous solution;

[0060] Step 2-3. According to the mass volume ratio of β-cyc...

Embodiment 3

[0070] A preparation method for veterinary Wuwei Changqing granules, comprising the following steps:

[0071] Step 1. Extract volatile oil:

[0072] First, after mixing Artemisia annua and Bupleurum, add water to it according to the volume ratio of material to liquid 1:12, reflux extraction at 100°C for 4 hours, collect volatile oil with a volatile oil collector, and obtain extract A, the extract of Artemisia annua and Bupleurum Medicinal residues, spare;

[0073] Step 2, preparation of volatile oil inclusion particles

[0074] Step 2-1, according to the mass ratio of volatile oil and glycerol of 1:30, add glycerol to the volatile oil collected in step 1, mix evenly to obtain volatile oil glycerol mixed solution;

[0075] Step 2-2, then according to the mass volume ratio of β-cyclodextrin to water: 1g: 10mL, add water to β-cyclodextrin, heat and dissolve in a boiling water bath to make β-cyclodextrin aqueous solution;

[0076] Step 2-3. According to the mass volume ratio of...

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PUM

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Abstract

The invention relates to a veterinary five-flavored evergreen particle preparation method which includes the steps: 1 mixing sweet wormwood herbs with Chinese thorowax roots, and performing reflux extraction with water to obtain volatile oil, extracting solution A and sweet wormwood herb and Chinese thorowax root residues; 2 adding glycerol into the volatile oil, uniformly mixing the glycerol andthe volatile oil to obtain volatile oil and glycerol mixing solution; adding water into beta-cyclodextrin, heating and dissolving the beta-cyclodextrin to prepare beta-cyclodextrin water solution; slowly adding the volatile oil and glycerol mixing solution into the beta-cyclodextrin water solution, and adding alcohol after stirring, refrigeration, suction filtration and drying to prepare volatileoil inclusion particles; 3 adding lightyellow sophora roots, antifeverile dichroa roots and lalang grass rhizome into the sweet wormwood herb and Chinese thorowax root residues, performing extractionwith water twice, combining secondary extracting solution B and the extracting solution A, performing spray drying after concentration, sieving products and adding auxiliary material pellets to obtainmedicinal material particles; 4 uniformly mixing the volatile oil inclusion particles with the medicinal material particles. The products prepared by the method are small in volatile oil smell, highin content and stable in quality.

Description

technical field [0001] The invention belongs to the field of preparation of veterinary medicines, and in particular relates to a preparation method of veterinary Wuwei Changqing granules. Background technique [0002] Chicken coccidiosis is a disease caused by a variety of coccidia of the genus Eimeria parasitic in the intestinal tract of chickens. Cause huge economic losses, affect food safety at the same time, damage human health. Long-term large-dose use of antibiotics and chemical synthetic drugs to prevent and treat the disease is prone to produce toxic side effects and drug resistance, and also cause public safety problems such as drug residues; The alkaloids in it have the effect of inhibiting and killing coccidia, Bupleuri can clear away heat and detoxify, have antibacterial and anti-inflammatory effects, and the rhizome of Rhizoma Imperatae has hemostatic effect. The five flavors of medicine are compatible, and the Wuwei Changqing granule made of it has a good cura...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K47/69A61K9/16A61K47/38A61K47/26A61P33/02
CPCA61K9/1623A61K9/1652A61K9/1682A61K36/185A61K36/233A61K36/282A61K36/489A61K36/899A61K2236/331A61K2236/39A61K2300/00
Inventor 韩愈杰邵谱李定刚杜伟伟张盼盼
Owner BAODING JIZHONG PHARMA
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