Cannabinoid effervescent tablet and preparation method thereof

A technology of cannabinoids and effervescent tablets, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of low bioavailability, unstable CBD content, hemp seed oil, etc. Inconvenient to carry and store, etc., to achieve high bioavailability, short disintegration time, and quantifiable production indicators

Active Publication Date: 2022-07-15
HANYI BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These products have some disadvantages: the content of CBD in CBD water is unstable; CBD water and hemp seed oil are inconvenient to carry and store; cannabinoids in cakes, fudge, chocolate and other cannabinoid-containing products need to be digested and absorbed, and cannabinoids cannot Direct absorption, low bioavailability

Method used

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  • Cannabinoid effervescent tablet and preparation method thereof
  • Cannabinoid effervescent tablet and preparation method thereof
  • Cannabinoid effervescent tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0127] Example 1: Preparation of water-soluble complex solution

[0128] 1. The specific formula (weight percent content) of the water-soluble compound solution is shown in Table 1:

[0129] Table 1 Water-soluble compound solution formula table

[0130]

[0131]

[0132] 2. Preparation process

[0133] (1) The first group of preparation processes (process 1)

[0134] Prepare the water-soluble compound solution according to the proportions of formulas 1-6, as follows:

[0135] a. Dissolution: β-cyclodextrin, hydroxypropyl-β-cyclodextrin, methyl-β-cyclodextrin, propylene oxide-β-cyclodextrin, Poloxamer 188, PEG-PLAG16000, PEG - One or more of PCL3000, PEG-PLA / PTX2000, PEG-b-PS6000, EDTA-2Na, sodium thiosulfate, mannitol and citric acid are added to 3 times of water and dissolved;

[0136] b. Mixing and dissolving: adding cannabidiol (CBD), stirring at 85° C. for 2 hours, the solution is a clear and transparent water-soluble compound solution after stirring, and the par...

Embodiment 2

[0149] Example 2: Preparation of Cannabinoid Composite Particles

[0150] The cannabinoid composite particles are obtained by drying the water-soluble composite solution obtained in Example 1, and the drying is freeze-drying or drying under reduced pressure.

[0151] 1. Freeze-drying process: put the water-soluble compound solution in Example 1 into a freeze-drying box, freeze at -40°C for 3h, vacuum at 100Pa, primary drying temperature 10°C, drying for 36h; secondary drying temperature 30°C, Dry for 24h; after drying, the material is sieved through No. 5 sieve to granulate;

[0152] 2. Decompression drying process: put the water-soluble compound solution in Example 1 into a decompression drying oven, the temperature is 50°C, the vacuum degree is 0.04Mpa, and it is dried for 48 hours. After drying, the material is passed through a No. 5 sieve to granulate.

[0153] The comparison between freeze drying process and vacuum drying process is shown in Table 4:

[0154] Table 4 Co...

Embodiment 3

[0157] Example 3: Preparation of Cannabinoid Effervescent Tablets

[0158] 1. Formulation: cannabinoid-containing composite granules (powder obtained by drying process in Example 2), sodium bicarbonate, sodium carbonate, tartaric acid, citric acid, aspartame, direct-pressed lactose, sodium chloride, polyethylene glycol Alcohol, vitamin C, sucrose fine particles, apocarotene aldehyde, beta carotene, sucralose, essence, sodium fumarate, leucine. The specific formula (weight percentage content) is as follows:

[0159] Table 5 Formulation of cannabinoid effervescent tablets

[0160]

[0161] 2. Preparation process

[0162] According to the formula in Table 5, the cannabinoid composite particles (powder obtained by drying process in Example 2), sodium bicarbonate, sodium carbonate, tartaric acid, citric acid, aspartame, direct-pressed lactose, sodium chloride, polyethylene Diol, vitamin C, sucrose fine granules, apocarotene aldehyde, beta carotene, sucralose, essence, sodium ...

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Abstract

The invention discloses a cannabinoid effervescent tablet and a preparation method thereof. The cannabinoid effervescent tablet comprises cannabinoid composite particles and a disintegrating agent, wherein the content of the cannabinoid composite particles in percentage by weight is 1-40%, and the content of the disintegrating agent in percentage by weight is 40-80%. The preparation method comprises the following steps: (1) preparing a water-soluble compound solution from cannabinoid, an amphiphilic high-molecular polymer and cyclodextrin; (2) drying the water-soluble compound solution obtained in the step (1) to obtain cannabinoid composite particles; and (3) preparing the cannabinoid composite particles obtained in the step (2) into the cannabinoid effervescent tablets. The cannabinoid effervescent tablet is high in drug loading capacity, low in water consumption in the preparation process, high in stability, simple in process, low in cost and short in inclusion time. The preparation method also solves the sticking problem of conventional cannabinoid effervescent tablets in the preparation process.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a cannabinoid effervescent tablet and a preparation method thereof. Background technique [0002] Cyclodextrin (CD) is a general term for a series of cyclic oligosaccharides produced by amylose under the action of cyclodextrin glucosyltransferase produced by Bacillus. Inclusion complex refers to an inclusion complex formed by one (drug) molecule being embedded in the cavity structure of another substance molecule (constituent), or called "molecular capsule". Among them, the inclusion molecules with a hole structure are called host molecules, and the embedded molecules are called guest molecules. Different types of main molecules can form inclusion compounds of different structures, such as tubular, layered, cage-like, single-molecule inclusion compounds, molecular sieve inclusion compounds or macromolecular inclusion compounds. Cyclodextrin inclusion complex is an inc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/10A61K47/34A61K47/69A61K36/60A61K31/05A61K31/352A61P29/00A61P35/00A61P35/02A61P25/08A61P25/16A61P25/28A61P1/16
CPCA61K9/2031A61K9/205A61K9/0007A61K47/6951A61K36/60A61K31/05A61K31/352A61P29/00A61P35/00A61P35/02A61P25/08A61P25/16A61P25/28A61P1/16A61K9/20A61K47/10A61K47/34A61K47/69A61K31/4745A61K9/16
Inventor 谭昕王曙宾范德凯
Owner HANYI BIO TECH CO LTD
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