Cefathiamidine composition
A cefathiamidine and composition technology, which is applied in the directions of inactive components of polymer compounds, antibacterial drugs, organic active components, etc., can solve the problems of long-term storage, easy oxidative deterioration, short antibacterial time, etc., and achieves hard oxidative deterioration. , long antibacterial time, good stability
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Embodiment 1
[0025] First, 250 grams of hydroxypropyl-β-cyclodextrin is dissolved in 1500 grams of water for injection to obtain a hydroxypropyl-β-cyclodextrin solution. Then add 50 grams of cefathiamidine into the hydroxypropyl-β-cyclodextrin solution, heat to 40°C, and heat and stir at 40°C for 4 hours for inclusion, after the inclusion is completed, the mixture is cooled to room temperature and filtered After obtaining the filtrate.
[0026] 15 grams of low-molecular-weight dextran was heated and dissolved with 45 grams of water for injection to obtain a low-molecular-weight dextran solution, cooled to room temperature, and filtered. Add the low-molecular-weight dextran solution into the inclusion solution of hydroxypropyl-β-cyclodextrin and cefathiamidine, stir to dissolve, then add 5 grams of vitamin C, stir to dissolve, and adjust the pH value with a 5% citric acid solution to 5.0, finally add water for injection to 2000ml, stir evenly, and then filter and sterilize with a 0.22μm mi...
Embodiment 2
[0028] Firstly, 450 grams of hydroxypropyl-β-cyclodextrin is dissolved with 2600 grams of water for injection to obtain a hydroxypropyl-β-cyclodextrin solution. Then add 100 grams of cefathiamidine into the hydroxypropyl-β-cyclodextrin solution, heat to 45°C, heat and stir at 45°C for 3.5 hours for inclusion, after the inclusion, cool the mixture to room temperature, filter After obtaining the filtrate.
[0029] Heat and dissolve 25 grams of low-molecular-weight dextran with 80 grams of water for injection to obtain a low-molecular-weight dextran solution, cool to room temperature, and filter. Add the low-molecular-weight dextran solution into the inclusion solution of hydroxypropyl-β-cyclodextrin and cefathiamidine, stir to dissolve, then add 8 grams of vitamin C, stir to dissolve, and adjust the pH value with a 6% citric acid solution To 4.8, finally add water for injection to 3500ml, stir evenly, and then filter and sterilize with a 0.22μm microporous membrane, and fill it...
Embodiment 3
[0031] First, 800 grams of hydroxypropyl-β-cyclodextrin is dissolved with 4400 grams of water for injection to obtain a hydroxypropyl-β-cyclodextrin solution. Then add 200 grams of cefathiamidine into the hydroxypropyl-β-cyclodextrin solution, heat to 50°C, and heat and stir at 50°C for 3 hours to carry out inclusion. After the inclusion is completed, the mixture is cooled to room temperature and filtered. After obtaining the filtrate.
[0032] 40 grams of low-molecular-weight dextran was heated and dissolved with 160 grams of water for injection to obtain a low-molecular-weight dextran solution, cooled to room temperature, and filtered. Add the low-molecular-weight dextran solution into the inclusion solution of hydroxypropyl-β-cyclodextrin and cefathiamidine, stir to dissolve, then add 12 grams of vitamin C, stir to dissolve, and adjust the pH value with a 7% citric acid solution To 4.7, finally add water for injection to 6000ml, stir evenly, and then filter and sterilize w...
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