Patch for treating miocardial infarction

A patch and weight ratio technology, which is applied to cardiovascular system diseases, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of toxic side effects, long treatment cycle, etc., and achieve small irritation and short inclusion time , no toxic side effects

Inactive Publication Date: 2009-12-02
TIANJIN ZHONGBAO PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most of the drugs for the treatment of myocardial infarction are oral preparations, and no external preparations have been seen. Oral administration has a long treatment cycle and relatively large toxic and side effects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 (general dosage)

[0020] The plaster for treating myocardial infarction is made according to the following method: 7.5 kg of safflower, 6.5 kg of peach kernel, and 6.5 kg of wulingzhi.

[0021] Crush safflower, peach kernels and Wulingzhi into coarse powder, add water and decoct 1-3 times, 1-3 hours each time, combine the decoction, filter, and measure the relative density of 1.00 when the filtrate is concentrated to 80°C -1.20 of clear cream.

[0022] Combine the above-mentioned clear ointments, continue to concentrate to 80°C, measure the clear ointment with a relative density of 1.10-1.30, and then add dressings; Add distilled water, mix evenly, and prepare cloth ointment.

[0023] Apply cloth paste on cloth or non-woven fabric or polyethylene sheet, dry in low humidity, paste on breathable adhesive tape, cover with liner, cut into small pieces, quality control, pack and put into storage.

Embodiment 2

[0024] Example 2: Investigation on the Stability of Drug Patch for the Treatment of Myocardial Infarction

[0025] According to the "Technical Requirements for New Drug Research of Traditional Chinese Medicine" promulgated and implemented by the State Food and Drug Administration, the technical requirements for quality stability research of new traditional Chinese medicines are stipulated. The ointment and patch for treating angina pectoris were made according to the established process, and the properties, moisture retention, content and microbiological inspection items were observed at room temperature. The results show that all the control indicators meet the national paste and ointment quality standards, and the quality is stable after being placed at room temperature for six months.

Embodiment 3

[0026] Embodiment 3: the pharmacodynamics test data of the drug patch for the treatment of myocardial infarction:

[0027] 1. Purpose of the test: The ointment and patch for the treatment of myocardial infarction are compound external patches refined from medicinal materials such as safflower, peach kernel and wulingzhi as active ingredients.

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PUM

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Abstract

The invention discloses a patch for treating miocardial infarction, which comprises the following components according to the parts by weight: 5-10 parts of safflower, 3-10 parts of peach kernel and 3-10 parts of trogopterus dung. A method for preparing the patch comprises the following steps: the raw materials are uniformly mixed and ground according to a proportion, and the grain diameter of each component is between 100 microns and 200 microns; CO2 supercritical fluid extraction is adopted, and a fractionating tower is used for fractionating and obtaining required fractions; after all components in the formula are processed through nanometer disperse equipment, the components are prepared into a nanometer medicinal slurry according to the proportion of the formula; required skin penetration enhancers and pressure-sensitive adhesive are added; the obtained mixture enters a spiral low-temperature drying and coating machine; and after coating, processes of cutting, quality inspection, packaging and storage are carried out. A scientific method is used for processing and extracting medicinal materials and filling the medicinal materials in a skeleton of a matrix, and the compatibility of the matrix of the patch with skin is good and beneficial to drug molecules to pass through, thus the patch has stable medicinal property and the characteristics of quick percutaneous absorption, good air permeability, gradual medicine release, and the like. Compared with an oral formulation, the patch has no intestinal tract first pass effect, is not influenced by the degradation of gastrointestinal tracts and has high bioavailability, convenient use, accurate dosage and fixed absorption area and the advantages of long-term action, skin absorption and convenient carrying and use.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, in particular to a patch for treating myocardial infarction. Background technique [0002] Hyperlipidemia and cholesterol are the main factors causing thrombus and myocardial infarction. The treatment and prevention of thrombus and myocardial infarction starts with lowering blood lipid and cholesterol. Pharmacology and Clinical Practice of Traditional Chinese Medicine, 1990, 6(6), pp. 1-4, Peng Kang and Zheng Youshun, "Research on Disassembled Prescription of Xuefu Zhuyu Decoction—Pharmacological Effect on Microcirculation" proves that it can improve microcirculation, Increased blood pressure caused by increased microvascular resistance has a certain inhibitory effect. [0003] At present, the drugs for the treatment of myocardial infarction mostly use oral preparations, but no external preparations have been seen. Oral administration has problems such as long t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61K9/70A61K47/02A61K47/42A61P9/10A61K35/24
Inventor 李建民郝彬梁友
Owner TIANJIN ZHONGBAO PHARMACY
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