56results about How to "Improved dissolution properties" patented technology

The invention discloses a method for preparing a solid preparation. The method comprises the following steps of: dissolving active ingredients of a water-insoluble and / or slightly water-soluble alkaline medicament into acid solution containing an acidulant to obtain medicament-containing acid solution; and uniformly mixing a basifier, excipients and the medicament-containing acid solution, and performing wet granulation, wherein the basifier ensures that the acidity of mixed solution of the basifier and the medicament-containing acid solution is reduced compared with the acidity of the medicament-containing acid solution. The invention also discloses the solid preparation prepared by the method. The method overcomes the disadvantages of serious pollution, high loss and serious potential safety hazards caused by mechanical pulverization treatment, is easy and convenient to operate, has high safety factor, and is easily applied to industrialized production. The solid preparation prepared by the method has dissolution characteristic which is remarkably improved compared with that in the prior art, and has the stability and content uniformity which are equivalent to or better than those in the prior art.

The invention discloses a preparation method of a medicament solid preparation. The method comprises the following steps of: dissolving active ingredients of a water-insoluble and / or water-poorly-soluble acid medicament into an alkaline solution containing a basifier to obtain a medicament-containing alkaline liquid; and uniformly mixing auxiliary materials with the medicament-containing alkaline liquid, and performing wet process pelletizing. The invention further discloses a medicament solid preparation prepared with the method. Due to the adoption of the preparation method disclosed by the invention, the defects of severe pollution, large loss and severe potential safety hazard caused by mechanical smashing treatment are overcome, and the effects of reducing the particle sizes of the active ingredients of the water-insoluble and / or water-poorly-soluble acid medicament in a pelletizing process is achieved. The method is easy and convenient to operate, is practicable, has high safety coefficient, and is easily applied to industrial production. The solid preparation prepared with the method has excellent dissolving characteristic, stability and content uniformity.

The invention belongs to the technical field of resourceful utilization of organic solid wastes, and specifically discloses a method for preparing carbon black from pyrolysis coke of a waste tire through molten salt heat treatment, and a product prepared by using the same. The method comprises the following steps: heating one or two selected from the group consisting of a metal chloride salt groupand a metal sulfate salt group so as to obtain molten salt; adding the pyrolysis coke of the waste tire into the molten salt, and carrying out molten salt heat treatment under a preset reaction atmosphere; and after completion of a reaction, separating a reaction product into secondary molten salt and treated pyrolysis coke, washing treated pyrolysis coke with hot water, carrying out drying so asto obtain the carbon black, and recycling the secondary molten salt at the same time. According to the invention, by utilization of the melting characteristic of the molten salt, impurity componentsin the pyrolysis coke of the waste tire are dissolved out, so the use of strong acids and strong alkalies like nitric acid, hydrochloric acid and an alkali liquor is avoided; meanwhile, through addition of metal chloride salt, the low-temperature melting characteristic of the molten salt is reinforced; and by utilization of metal sulfate salt, acidic gases like hydrogen sulfide and hydrogen chloride are captured in situ at the same time.

A production method of an aripiprazole solid preparation and the preparation produced by the method are disclosed. The method comprises: dissolving aripiprazole in the acid solution containing acidifying agent to obtain an acid liquid of the medicine; later, homogeneously mixing adjuvants and the acid liquid of the medicine, carrying out wet granulation.

The invention relates to mixing refrigerant used in the low temperature stage of the two stage cascade system refrigeration system. The mixing refrigerant includes ethane, full fluorine ethane or / and fluoroform. It can be made up of ethane whose molar concentration is 25%-95% and full fluorine ethane whose is the rest. And it also can be made up of ethane whose is 45%-75% and fluoroform whose is the rest. It also can include all three of them whose respectively is 25%-90%, 5%-60%, and the rest. Its advantages are that it has high efficiency and evaporating pressure; its ODP is zero; the GWP is greatly reduced compared with the R503 and R5088; and it has good inter-solubility with lubricating oil.

A preparation method of solid formulations and the solid formulations prepared thereby are disclosed. The method comprises the steps of: dissolving insoluble or slightly soluble basic active ingredients in an acid solution comprising acidifiers, then, homogenously mixing the acidic solution of active ingredients with adjuvants, and granulating by wetting granulation method.

The invention discloses a pharmaceutical composition containing baricitinib and its preparation method and application. The pharmaceutical composition comprises baricitinib and pharmaceutically acceptable auxiliary materials, wherein the auxiliary materials include fillers and disintegrants. The preparation method of the pharmaceutical composition comprises: uniformly mixing a filler and a disintegrant to obtain mixed excipients; uniformly mixing the baricitinib bulk drug with the mixed excipients or granulating the baricitinib bulk drug The liquid is uniformly mixed with the mixing excipients, and the drug-loaded granules of the solid pharmaceutical composition containing baricitinib are obtained by granulation. The present invention controls the particle size of baricitinib, uses hydrophilic auxiliary materials microcrystalline cellulose, mannitol, etc. The solid pharmaceutical composition containing baricitinib has a simple preparation process and is suitable for industrialization.

The invention relates to an oral preparation and a preparation method thereof. The preparation contains lurasidone hydrochloride, a micronized particle of a dispersion supporter, microcrystalline cellulose and a water-soluble polymer adhesive. More specifically, the invention relates to the oral preparation and especially to a tablet. The preparation has a fast dissolution characteristic, and dissolution characteristics of an active component are identical; even though the content of the active component in the preparation changes in a certain range, the dissolution characteristics of the active component are still identical.

The invention provides micronized fexofenadine hydrochloride. The particle size of fexofenadine hydrochloride at 95% cumulative volume is 60mu m or below. The invention also provides a method for preparing the micronized fexofenadine hydrochloride, a pharmaceutical composition containing the micronized fexofenadine hydrochloride, as well as a preparation method of the pharmaceutical composition. According to the invention, a solid preparation by taking the micronized fexofenadine hydrochloride as the active ingredient has excellent dissolution rate in vitro and has high dissolution characteristics under various pH conditions, the corresponding effects of the medicine in vivo in different crowds can be effectively guaranteed, and the problem that the bioavailability of the medicine in vivo is reduced so as to influence the curative effect because the conventional fexofenadine hydrochloride medicine is difficult to dissolve in an in-vivo gastrointestinal environment is solved.