56results about How to "Improved dissolution properties" patented technology

The invention discloses a sparingly soluble active component particle, a particle preparation and a preparation method thereof. The preparation method of the sparingly soluble active component particle comprises the following steps: dissolving sparingly soluble active component and ionic polymer into an alkaline solution or an acidic solution, and then mixing the alkaline solution and acidic solution to change the pH value of solutions so as to precipitate the sparingly soluble active component and ionic polymer from the mixed solution to form particles; and the performance of the sparingly soluble active component particle is improved. According to the preparation method, sparingly soluble active component and ionic polymer are co-precipitated, at the same time, a preparation technology is adopted, and two technologies are tightly combined to prepare the sparingly soluble active component particle preparation. The prepared preparation has the advantages of excellent dissolving-out characteristic, high bioavailability, small individual difference, good stability, and good content uniformity.

The invention discloses the preparation method of aripiprazole solid preparation. The method comprises the following steps of dissolving aripiprazole into acidic solution containing an acidifying agent to obtain medicine-containing acidic solution; and then uniformly mixing accessory with the medicine-containing acidic solution to granulate by a wet method. The invention also discloses aripiprazole solid preparation prepared by the method. According to the method disclosed by the invention, the defects of the serious pollution, high loss and serous potential safety hazards brought by mechanical crushing treatment are avoided; and the method is simple, convenient and feasible for operation and easy for industrial production and has high safety coefficient. The aripiprazole solid preparation prepared by the method has the advantages of excellent dissolution property, stability, and content uniformity.

The invention relates to a method for storing the color and luster and flavor of Chinese chestnut-lotus root composite ultramicro whole powder with easy gelatinization, and belongs to the field of the food processing of fruits and vegetables. The method comprises the following main processes of: peeling Chinese chestnuts and fresh lotus roots, cutting into slices, and keeping colors by using a composite color fixative prepared from citric acid, ascorbic acid and N-acetylcysteine; freeze-drying by microwave to prepare dried slices; and crushing the dried slices of the Chinese chestnuts and thelotus roots coarsely, mixing, and performing airflow type ultramicro full crushing to prepare the Chinese chestnut-lotus root composite ultramicro whole powder with the easy gelatinization. In the processing process, the change of the color and luster in the drying and crushing processes in the later period can be controlled by color-keeping processing; in the drying process, the change degree ofthe color and luster and flavor in the conventional hot-air drying process is reduced obviously by the microwave freeze-drying technology; and in the crushing process, the loss of excessive heat generated by the mechanical shearing crushing technology on the color and luster and flavor is prevented effectively by the airflow type ultramicro full crushing technology, and the flavor and nutrition of the Chinese chestnuts and the lotus roots can be better mixed by high-pressure air combination in the ultramicro full crushing process.

The invention discloses a method for preparing a solid risperidone preparation. The method comprises the following steps of: dissolving risperidone into acid solution containing an acidulant to obtain medicament-containing acid solution; and uniformly mixing excipients and the medicament-containing acid solution, and performing wet granulation. The invention also discloses the solid risperidone preparation prepared by the method. The method overcomes the disadvantages of serious pollution, high loss and serious potential safety hazards caused by mechanical pulverization treatment, is convenient and easy to operate, has high safety factor, and is easily applied to industrialized production. The solid risperidone preparation prepared by the method has excellent dissolution characteristic, stability and content uniformity.

The invention discloses a method for preparing a solid zopiclone preparation. The method comprises the following steps of: dissolving zopiclone into acid solution containing an acidulant to obtain medicament-containing acid solution; and uniformly mixing a basifier, excipients and the medicament-containing acid solution, and performing wet granulation, wherein the basifier is a reagent which ensures that the acidity of mixed solution of the basifier and the medicament-containing acid solution is reduced compared with the acidity of the medicament-containing acid solution. The invention also discloses the solid zopiclone preparation prepared by the method. The method overcomes the disadvantages of serious pollution, high loss and serious potential safety hazards caused by mechanical pulverization treatment, is convenient and easy to operate, has high safety factor, and is easily applied to industrialized production. The solid zopiclone preparation prepared by the method has excellent dissolution characteristic, stability and content uniformity.

The invention discloses a drug composition containing baricitinib and a preparation method and application of the drug composition. The drug composition comprises the baricitinib and an auxiliary material which can be received pharmaceutically, wherein the auxiliary material comprises a filling agent and a disintegrating agent. The preparation method of the drug composition comprises the steps that the filling agent and the disintegrating agent are evenly mixed, so that the mixed auxiliary material is obtained; and then a baricitinib crude drug and the mixed auxiliary material are evenly mixed or pelletizing liquor containing the baricitinib crude drug is evenly mixed with the mixed auxiliary material, and drug-carrying pellets of the solid drug composition containing the baricitinib are obtained through pelletizing. According to the drug composition containing the baricitinib and the preparation method and application of the drug composition, the solid drug composition which can be dissolved out rapidly in vitro and contains the baricitinib is prepared by controlling the particle size of the baricitinib, using microcrystalline cellulose, mannitol and the like in the hydrophilic auxiliary material as the filling agent, and using croscarmellose sodium and the like as the disintegrating agent; and the preparation technique is simple and suitable for industrialization.

The invention provides a manufacturing method for a high temperature-resistant high-strength flexible graphite material. The manufacturing method comprises the following steps: with expandable graphite as a raw material, adding an additive solution into the expandable graphite to soak the expandable graphite; carrying out filtering; repeatedly flushing the soaked expandable graphite with a filtrate and controlling moisture content in the expandable graphite to be 18 to 40% of the total weight of the expandable graphite; drying the expandable graphite to obtain modified expandable graphite; and subjecting the modified expandable graphite to expansion, rolling compaction and molding so as to obtain the high temperature-resistant high-strength flexible graphite material which has low ignition loss and high tensile strength. According to the manufacturing method for the high temperature-resistant high-strength flexible graphite material in the invention, a phosphorus agent and a boron agent are added into the flexible graphite material, so inoxidizability and strength of the material are improved; and the method has the advantages of a simple process, low cost and easy popularization.

The invention discloses a method for preparing myricetin/HP-beta-CD inclusion compound superfine granules through a supercritical CO2 anti-solvent technique. The method comprises the following steps of (1) compounding a myricetin-carrier mixed solution: weighing myricetin raw material medicines and a water-soluble carrier namely hydroxypropyl-beta-cyclodextrin, and enabling the weighed myricetin raw material medicines and the weighed water-soluble carrier namely hydroxypropyl-beta-cyclodextrin to dissolve in an organic solvent to obtain the myricetin-carrier mixed solution, wherein the organicsolvent is ethanol, and the molar ratio of the raw material medicines to the carrier is 1 to 1; (2) charging CO2 into a crystallization kettle at a certain flow rate, and regulating temperature and pressure in the crystallization kettle; (3) continuing charging the CO2, maintaining the temperature and the pressure in the crystallization kettle unchanged, and at the same time, spraying the myricetin-carrier mixed solution prepared in the step (1) into the crystallization kettle from the top of the crystallization kettle through a nozzle by a high-pressure liquid delivery pump; and (4) after completion of sample introduction, continuing charging the CO2 for some time, completely discharging remaining solvents, releasing pressure, opening the crystallization kettle, and collecting products.The myricetin/HP-beta-CD inclusion compound superfine granules obtained by the method can notably improve dissolving-out properties, and improvement of the biological availability of the myricetin isfacilitated.

The invention relates to low temperature stage mixed refrigerant applicable to two-stage cascade refrigeration systems. The mixed refrigerant comprises ethane and monofluoro-methane, and is formed through physical mixture, wherein the molarity of ethane is 50 to 75 percent, and the balance is monofluoro-methane. The mixed refrigerant can also comprises ethane, monofluoro-methane and perfluoroethane, and is formed through physical mixture, wherein the molarity of ethane is 40 to 70 percent; the molarity of monofluoro-methane is 5 to 40 percent; the balance is perfluoroethane. The mixed refrigerant has high efficiency and high evaporation pressure, as well as good refrigeration capacity under the same compressor displacement, has zero ODP, greatly decreases GWP than R503 and R508B, and has good intersolubility with lubricating oil.

The invention discloses rasagiline or a medicinal salt sublingual film agent thereof as well as a preparation method and application of the rasagiline or the medicinal salt sublingual film agent. The sublingual film agent comprises the following prescription components: 0.5-15% of rasagiline or a pharmaceutical salt thereof, 30-85% of a polymer film-forming material, 5-40% of dextrin and 0-30% of other auxiliary materials (not 0), and the dextrin is one or more of maltodextrin, hydroxypropyl-beta-cyclodextrin, glucosyl-beta-cyclodextrin and sulfobutyl-beta-cyclodextrin; the percentage is the mass percentage of each component relative to the total components of the prescription of the sublingual film agent. The sublingual membrane disclosed by the invention can be adhered to an administration part and quickly dissolved without water, and a patient does not need to swallow, so that the sublingual membrane is good in compliance; through oral mucosa absorption, the first-pass effect of the liver is avoided, and the bioavailability is high; the stability is good, and the impurity content is still low after long-term storage; the pharmaceutical composition has a good dissolution characteristic, is rapid and complete in drug dissolution, is rapidly absorbed by sublingual mucosa and enters blood circulation, and takes effect rapidly.

The invention discloses preparation methods of a cymipristone solid preparation. A method 1 comprises the following steps: dissolving cymipristone in a solvent to obtain a drug-containing solution, then evenly mixing auxiliary materials with the drug-containing solution, and performing wet granulation, wherein, the solvent is an organic solvent or an aqueous solution containing more than 85% of an organic solvent by mass percent. A method 2 comprises the following steps: dissolving the cymipristone in an acid solution containing an acidulant to obtain a drug-containing acid solution, then evenly mixing the auxiliary materials with the drug-containing acid solution, and performing wet granulation. The invention further discloses the cymipristone solid preparation prepared by the methods. The preparation methods disclosed by the invention avoid the defects such as serious pollution, great loss and serious potential safety hazard caused by mechanical pulverization, and the methods are simple and feasible in operation and have a high safety factor, thus being applicable to industrial production. The cymipristone solid preparation prepared by the methods has the advantages of excellent leaching property, better stability and better content uniformity.

Provided is a pharmaceutical composition for oral administration in which the solubility and/or dissolution properties of enzalutamide are improved and supersaturation is maintained. Also provided is a pharmaceutical composition for oral administration in which the oral absorbability of enzalutamide is improved. The pharmaceutical composition for oral administration comprises enzalutamide and polyvinyl alcohol.

The invention discloses an oral solid pharmaceutical composition in a micronized form by using a solid preparation with a micronized homoharringtonine derivative as an active component. The composition comprises a pharmacological active agent with an effective dosage, crospovidone or polyvinylpyrrolidone, and an oral solid pharmaceutical composition used for a pharmacological active agent. The oral solid pharmaceutical composition has an excellent in-vitro dissolution rate, and has good dissolution rates in a variety of pH conditions, so that good absorption of medicines in different populations can be effectively ensured, and the problems that an existing homoharringtonine derivative drug is not easily dissolved out in an in-vivo gastrointestinal environment and then in-vivo bioavailability of drugs is reduced and efficacy is influenced can be solved.

The invention provides micronized fexofenadine hydrochloride. The particle size of fexofenadine hydrochloride at 95% cumulative volume is 60mu m or below. The invention also provides a method for preparing the micronized fexofenadine hydrochloride, a pharmaceutical composition containing the micronized fexofenadine hydrochloride, as well as a preparation method of the pharmaceutical composition. According to the invention, a solid preparation by taking the micronized fexofenadine hydrochloride as the active ingredient has excellent dissolution rate in vitro and has high dissolution characteristics under various pH conditions, the corresponding effects of the medicine in vivo in different crowds can be effectively guaranteed, and the problem that the bioavailability of the medicine in vivo is reduced so as to influence the curative effect because the conventional fexofenadine hydrochloride medicine is difficult to dissolve in an in-vivo gastrointestinal environment is solved.

The invention relates to a veterinary five-flavored evergreen particle preparation method which includes the steps: 1 mixing sweet wormwood herbs with Chinese thorowax roots, and performing reflux extraction with water to obtain volatile oil, extracting solution A and sweet wormwood herb and Chinese thorowax root residues; 2 adding glycerol into the volatile oil, uniformly mixing the glycerol andthe volatile oil to obtain volatile oil and glycerol mixing solution; adding water into beta-cyclodextrin, heating and dissolving the beta-cyclodextrin to prepare beta-cyclodextrin water solution; slowly adding the volatile oil and glycerol mixing solution into the beta-cyclodextrin water solution, and adding alcohol after stirring, refrigeration, suction filtration and drying to prepare volatileoil inclusion particles; 3 adding lightyellow sophora roots, antifeverile dichroa roots and lalang grass rhizome into the sweet wormwood herb and Chinese thorowax root residues, performing extractionwith water twice, combining secondary extracting solution B and the extracting solution A, performing spray drying after concentration, sieving products and adding auxiliary material pellets to obtainmedicinal material particles; 4 uniformly mixing the volatile oil inclusion particles with the medicinal material particles. The products prepared by the method are small in volatile oil smell, highin content and stable in quality.