Aripiprazole solid preparation and preparation method thereof

Abstract

A production method of an aripiprazole solid preparation and the preparation produced by the method are disclosed. The method comprises: dissolving aripiprazole in the acid solution containing acidifying agent to obtain an acid liquid of the medicine; later, homogeneously mixing adjuvants and the acid liquid of the medicine, carrying out wet granulation.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a solid preparation of aripiprazole and a preparation method thereof. Background technique [0002] Aripiprazole, chemical name 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1 hydrogen)- Quinolinone, molecular weight 448.39, belongs to quinolinone derivatives. It was developed by Otsuka Corporation of Japan and was first approved by the US FDA in November 2002. Aripiprazole is an atypical antipsychotic that exhibits presynaptic dopamine agonism and postsynaptic dopamine D 2 Antagonist action, with 5-HT 1a Partial receptor agonism and 5-HT 2 Receptor antagonism. Clinical trial studies have shown that aripiprazole can significantly improve the positive and negative symptoms of schizophrenia, and reduce the relapse rate of schizophrenia, while the effects of extrapyramidal side effects and weight gain are small, and it is also It does not cause an ...

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