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Aripiprazole solid preparation and preparation method thereof

A technology of aripiprazole and solid preparation, applied in the field of aripiprazole solid preparation and preparation thereof, can solve the problems of potential safety hazards, unsatisfactory dissolution characteristics of aripiprazole solid pharmaceutical preparation, large loss and the like

Active Publication Date: 2013-06-05
SHANGHAI ZHONGXI PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved by the present invention is to overcome the existing aripiprazole solid preparation method to select and control the particle size of aripiprazole through mechanical pulverization, which will cause environmental pollution, large loss, and serious safety hazards. Moreover, the dissolution characteristics of aripiprazole solid pharmaceutical preparations are still not ideal, and a method is provided that is easier to operate, less polluted, does not have the aforementioned safety hazards, and can ensure that the obtained solid preparations have excellent dissolution characteristics, stability and content. Preparation method of uniformity, and aripiprazole solid preparation prepared by the method

Method used

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  • Aripiprazole solid preparation and preparation method thereof
  • Aripiprazole solid preparation and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 5

[0054] Example 5 Aripiprazole tablet (5mg / tablet) formula and preparation method

[0055] drug

Embodiment 7 and 8

[0058] Embodiment 7 and 8 Aripiprazole tablet (5mg / tablet) formula and preparation method

[0059]

Embodiment 9

[0060] Example 9 Aripiprazole tablet (10mg / tablet) formula and preparation method

[0061] drug

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Abstract

A production method of an aripiprazole solid preparation and the preparation produced by the method are disclosed. The method comprises: dissolving aripiprazole in the acid solution containing acidifying agent to obtain an acid liquid of the medicine; later, homogeneously mixing adjuvants and the acid liquid of the medicine, carrying out wet granulation.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a solid preparation of aripiprazole and a preparation method thereof. Background technique [0002] Aripiprazole, chemical name 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1 hydrogen)- Quinolinone, molecular weight 448.39, belongs to quinolinone derivatives. It was developed by Otsuka Corporation of Japan and was first approved by the US FDA in November 2002. Aripiprazole is an atypical antipsychotic that exhibits presynaptic dopamine agonism and postsynaptic dopamine D 2 Antagonist action, with 5-HT 1a Partial receptor agonism and 5-HT 2 Receptor antagonism. Clinical trial studies have shown that aripiprazole can significantly improve the positive and negative symptoms of schizophrenia, and reduce the relapse rate of schizophrenia, while the effects of extrapyramidal side effects and weight gain are small, and it is also It does not cause an ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K9/20A61K9/48A61K31/496A61K47/02A61K47/04A61K47/12A61K47/16A61P25/18
CPCA61K9/1611A61K31/496A61P25/18
Inventor 郑斯骥谭波刘潇怡
Owner SHANGHAI ZHONGXI PHARMA
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