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Method for preparing solid preparation and solid preparation

A solid preparation and solvent technology, applied in the preparation of solid preparations and the field of solid preparations, can solve the problems of unsatisfactory dissolution characteristics of solid pharmaceutical preparations, potential safety hazards, environmental pollution, etc., achieving small individual differences, high safety factor, and avoiding serious pollution. Effect

Active Publication Date: 2013-04-17
SHANGHAI ZHONGXI PHARMA +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is to overcome the existing solid preparation method to select and control the particle size of the pharmaceutical active ingredient through mechanical pulverization, which will cause environmental pollution, serious safety hazards, large loss, and the resulting solid pharmaceutical preparation However, for water-insoluble or poorly water-soluble basic drugs, it is easier to operate, less polluted, without the aforementioned safety hazards, and can ensure that the prepared solid preparation has excellent dissolution characteristics. , preparation method of stability and content uniformity and obtained solid preparation

Method used

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  • Method for preparing solid preparation and solid preparation
  • Method for preparing solid preparation and solid preparation
  • Method for preparing solid preparation and solid preparation

Examples

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Effect test

Embodiment 12

[0041] Example 12 Formula and preparation method of dextro-zopiclone tablets (2mg / tablet)

[0042]

Embodiment 13

[0043] Example 13 Formula and preparation method of dexzopiclone tablets (2mg / tablet)

[0044]

Embodiment 14

[0045] Example 14 Formula and preparation method of dexzopiclone tablets (2mg / tablet)

[0046]

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PUM

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Abstract

A preparation method of solid formulations and the solid formulations prepared thereby are disclosed. The method comprises the steps of: dissolving insoluble or slightly soluble basic active ingredients in an acid solution comprising acidifiers, then, homogenously mixing the acidic solution of active ingredients with adjuvants, and granulating by wetting granulation method.

Description

Technical field [0001] The invention belongs to the field of pharmaceutical preparations, and specifically relates to a preparation method of a solid preparation and the obtained solid preparation. Background technique [0002] In the field of pharmaceutical preparations, the particle size of active pharmaceutical ingredients is closely related to the preparation process and quality of solid preparations. In the preparation process of specific pharmaceutical preparations, the particle size of the active pharmaceutical ingredient is usually selected according to the solubility characteristics of the drug and the permeability of the biomembrane. For example, if it is a drug with poor solubility and drug dissolution is a rate-limiting process of absorption, a smaller particle size can be selected to promote drug absorption. For another example, if it is a drug with poor compressibility, its compressibility can be improved by selecting a suitable particle size and adding suitable ex...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K9/16A61K47/02A61K47/12A61K47/20A61K47/26A61K47/32A61K47/34A61K47/38A61K47/40A61K47/44A61K31/496A61K31/4985A61K31/519A61P7/02A61P25/18A61P25/20A61P31/12
CPCA61K31/551A61K31/475A61K31/519A61K31/5513A61K31/506A61K31/165A61K31/454A61K47/02A61K47/12A61K31/496A61K9/1617A61K9/2009A61K31/4515A61K31/4985A61K9/2013A61K31/5517A61K31/567A61K31/5415A61K31/4164A61K31/7048A61K9/1611A61K31/166A61P7/02A61P25/18A61P25/20A61P31/12
Inventor 郑斯骥谭波
Owner SHANGHAI ZHONGXI PHARMA
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