A kind of preparation method of multi-substituted distal allyl ketone derivatives

A technology for allyl ketone and derivatives, which is applied in the field of preparation of multi-substituted distal allyl ketone derivatives, can solve the problems of large equipment requirements, harsh conditions, and low yield, and achieve low cost and mild reaction conditions , the effect of high research value
CN107973715BActive Publication Date: 2020-08-14HARBIN INST OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HARBIN INST OF TECH
Publication Date
2020-08-14

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Abstract

The invention relates to a method for preparing a polysubstituted distal-end allyl ketone derivative. An object of the invention is to provide the method for preparing the polysubstituted distal-end allyl ketone derivative. The method comprises the steps of dissolving a third-grade cyclitol derivative, an unsaturated olefin compound and a photocatalyst in an organic solvent in a nitrogen gas atmosphere at room temperature, carrying out uniform mixing, carrying out a lighting reaction under a blue LED (light emitting diode) lamp, carrying out rotary evaporation to remove the solvent, then, carrying out silica-gel column chromatographic separation and purification, thereby obtaining a product, i.e., the polysubstituted distal-end allyl ketone derivative. According to the method provided by the invention, the reaction can be carried out at normal temperature under normal pressure the reaction conditions are mild, and the yield can reach 80%; and the method has the advantages of simplicityin operation, no pollution, safety, environment-friendliness and low cost. The invention is applied to the field of organic synthesis.
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Description

technical field

[0001] The invention relates to a preparation method of a multi-substituted distal allyl ketone derivative. Background technique

[0002] Cycloalcohols widely exist in biologically active natural products and drug molecules, and are also important raw material intermediates for many chemical products and other natural products. According to literature reports, through a series of transformation reactions, various important Intermediates of chemical raw materials, such as unsaturated distal diketone ketone compound 1, distal enol compound 2, diol compound 3.

[0003]

[0004] At present, the synthesis of multi-substituted distal allyl ketone derivatives through ring-opening of ring alcohols mainly includes ring-opening fluorination of ring alcohols, alkynylation, cyanation, and amination, but direct allylation has not yet been reported. reports. Moreover, most of the existing synthesis methods use a high-temperature heating system, which consumes a lot of...

Claims

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