A method for synchronous detection of five colorants in hawthorn pills

A synchronous detection and colorant technology, applied in measuring devices, instruments, scientific instruments, etc., to achieve high accuracy, high detection efficiency, and good stability.

Active Publication Date: 2021-04-20
广西壮族自治区食品药品检验所
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, there are also detection methods for colorants in the open literature, but there is no related technology for the simultaneous detection of multiple colorants in Shanzha pills

Method used

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  • A method for synchronous detection of five colorants in hawthorn pills
  • A method for synchronous detection of five colorants in hawthorn pills
  • A method for synchronous detection of five colorants in hawthorn pills

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Embodiment 1

[0045] (1) Instruments and reagents

[0046] Agilent 1290 Rapid High Resolution Liquid Chromatography System; Agilent 6490Triple Quad LC / MS / MS Liquid Chromatography / Mass Spectrometry Instrument; Distribution Electrospray Ionization Source (ESI); Chromatographic column is Agilent Eclipse Plus C 18 (100×2.1mm, 1.8μm); Formic acid is chromatographically pure, acetonitrile is chromatographically pure, acetone is analytically pure, and water is high-purity water.

[0047] (2) Methods and results

[0048] A method for synchronous detection of 5 kinds of colorants in hawthorn pills, wherein said 5 kinds of colorants are Sudan Red I, Sudan Red II, Sudan Red III, Sudan Red IV and 808 Scarlet, and the detection method comprises the following steps:

[0049] (1) Preparation of blank matrix solution: Take 5g of blank matrix sample, weigh it accurately, add diatomaceous earth at a weight ratio of 1:0.67, pulverize it, and weigh it accurately; add 25ml of acetonitrile-acetone (1:1), and ul...

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PUM

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Abstract

The invention discloses a method for synchronous detection of five colorants in hawthorn pills, comprising the following steps: (1) preparation of a blank matrix solution; (2) preparation of a mixed reference solution; (3) preparation of a sample solution; 4) Perform liquid chromatography-tandem mass spectrometry analysis; (5) Analysis of results. The five colorants are Sudan Red I, Sudan Red II, Sudan Red III, Sudan Red IV and 808 Scarlet. This method has the advantages of simple operation, high accuracy, high precision, and good stability. It can detect one or more of 5 kinds of coloring agents at the same time. After dyeing with the above five colorants, it can be detected in batches with high detection efficiency.

Description

technical field [0001] The invention relates to the field of drug detection, in particular to a method for synchronous detection of five colorants in hawthorn pills. Background technique [0002] Hawthorn pills are large honey pills made by crushing hawthorn and white sugar, and adding refined honey in a certain proportion. It has the effect of eliminating accumulation and stagnation. hawthorn( Crataegus pinnatifida Bunge ), also known as Shanliguo, Shanlihong, Rosaceae Hawthorn, is a traditional medicinal and edible plant, containing flavonoids, flavonols, dihydroflavones and dihydroflavonols, flavanols and their polymers, More than 150 active substances such as triterpenoids, steroids, and organic acids. Hawthorn has the effects of lowering blood fat, blood pressure, strengthening the heart, and antiarrhythmia. It is also a good medicine for invigorating the spleen and appetizing, digesting stagnation, promoting blood circulation and resolving phlegm. Efficacy. Vitexin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 甘勇强张涛罗轶黄博张颖婷白桂昌谢培德
Owner 广西壮族自治区食品药品检验所
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