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A carboxymethylated modified product of enteromorpha polysaccharide with improved antioxidant activity and its preparation method

A technology for carboxymethylation and carboxymethylation of prolifera polysaccharide, which is applied in the field of carboxymethylated modified prolifera polysaccharide and its preparation field

Active Publication Date: 2020-07-31
GUILIN PAVAY GENE PHARMA
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  • Description
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Problems solved by technology

There are no domestic and foreign literature reports on the preparation and antioxidant activity of carboxymethylated derivatives of Enteromorpha polysaccharides

Method used

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  • A carboxymethylated modified product of enteromorpha polysaccharide with improved antioxidant activity and its preparation method
  • A carboxymethylated modified product of enteromorpha polysaccharide with improved antioxidant activity and its preparation method
  • A carboxymethylated modified product of enteromorpha polysaccharide with improved antioxidant activity and its preparation method

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Embodiment Construction

[0021] The technical solution of the present invention will be further described below through examples.

[0022] 1. Preparation of Enteromorpha polysaccharide

[0023] Enteromorpha was washed, dried at 50°C, crushed through a 20-mesh sieve, condensed and refluxed with 80% ethanol at 85°C and extracted three times for 2 hours each time, and the residue was separated and dried. Weigh 5g of the above residue, add distilled water according to a certain ratio of material to liquid, extract in a water bath, filter with suction, centrifuge the filtrate to obtain a concentrated supernatant, add 4 times the volume of absolute ethanol to precipitate, let stand at 4°C for 48h, and centrifuge at 4000r / min for 15min. The precipitate was taken and dried to obtain the crude polysaccharide of Enteromorpha enteromorpha (EIP).

[0024] 2. Carboxymethylation modification of Enteromorpha polysaccharide

[0025] Weigh 120mg of Enteromorpha polysaccharide, add 10mL of 20% NaOH and 25mL of isopro...

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Abstract

The invention relates to a carboxymethylation modification method for enhancing the antioxidant activity of enteromorpha prolifera polysaccharide. A sodium hydroxide-chloroacetic acid method is adopted to carry out carboxymethylation modification, and with the degree of substitution in carboxymethylation as an index, single factors are used for studying the influence of three factors (NaOH concentration, reaction time and reaction temperature), so that carboxymethylated enteromorpha prolifera polysaccharides with different degrees of substitution are obtained. The invention further relates tothe application of the carboxymethylated enteromorpha prolifera polysaccharides in pharmacy, particularly application in the preparation of antioxidant medicines, including application in DPPH free radial-eliminating medicines, hydroxyl free radical-eliminating medicines, superoxide anion-eliminating medicines and Fe<3+> reducing capacity medicines. The invention applies the artificially synthesized carboxymethylated enteromorpha prolifera polysaccharides with different degrees of substitution in in-vitro antioxidant activity experiments, provides a reference for the application of the carboxymethylated enteromorpha prolifera polysaccharides in the field of medicines.

Description

technical field [0001] The invention relates to a seaweed polysaccharide, in particular to a carboxymethylated modified product of Enteromorpha polysaccharide with improved antioxidant activity and a preparation method thereof. Background technique [0002] Enteromorpha is a large-scale economical green algae, commonly known as moss strips and seaweed, belonging to the phylum Chlorophyta, Ulvaceae of the order Ulva. Research has found that Enteromorpha is rich in carbohydrates, protein, crude fiber, amino acids, fatty acids, polysaccharides, vitamins and various mineral elements, among which Enteromorpha polysaccharides have the highest content, mainly composed of rhamnose, xylose, glucose and a small amount of mannose It is composed of monosaccharides such as sugar, galactose, and arabinose, and contains uronic acid and sulfate groups. The main chain of polysaccharides contains a variety of linkage types. Modern pharmacological studies have proved that polysaccharides from...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61K31/715A61P39/06
CPCA61K31/715A61K36/05C08B37/0003C08B37/006
Inventor 李霞熊峰郑里华崔萌佳郝再彬
Owner GUILIN PAVAY GENE PHARMA
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