Detection method for screening illegal additives in weight-reducing health food based on real-time direct analysis ion source-high resolution mass spectrum combined use

A real-time direct analysis, high-resolution mass spectrometry technology, which is used in the preparation of test samples, analysis of materials, and material analysis by electromagnetic means. The effect of combining high sensitivity, reducing extraction loss and accurate screening

Inactive Publication Date: 2018-05-11
BEIJING ENTRY EXIT INSPECTION & QUARANTINE BUREAU INSPECTION & QUARANTINE TECH CENT
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Problems solved by technology

However, common detection methods usually involve several or more target compounds and require complex pretreatment processes, which not only consume manpower and material resources, but also have certain hazards to the environment, and are prone to false negative results.

Method used

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  • Detection method for screening illegal additives in weight-reducing health food based on real-time direct analysis ion source-high resolution mass spectrum combined use
  • Detection method for screening illegal additives in weight-reducing health food based on real-time direct analysis ion source-high resolution mass spectrum combined use

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Embodiment

[0024] 1 Instruments and reagents

[0025] LTQ Orbitrap XL linear ion trap orbital ion trap mass spectrometer (Thermo Fisher Scientific, Germany), DART real-time direct analysis ion source (Ion Sense, USA), XCalibur 2.2 software (Thermo Fisher Scientific, MA, USA), Tox ID 2.1.1 ( Thermo Fisher Scientific, MA, USA). Methanol (chromatographically pure, TEDIA, USA), ultrapure water (18.2MΩ) were prepared by Milli-Q Advantage A10 ultrapure water system.

[0026] Reference substance: caffeine (source: Chinese Academy of Metrology, batch number: 16001); sibutramine hydrochloride, ephedrine hydrochloride, fenfluramine hydrochloride, phenylpropanolamine hydrochloride, phenolphthalein (source: National Institute for the Control of Pharmaceutical and Biological Products, The batch numbers are: 100624-201501; 171241-201506; 100073-201507; 100217-201503; 100091-201501); Phentolamine mesylate (source: Bailingwei, batch number: LSB0O102).

[0027] Samples: 11 batches of weight-loss health foods ...

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Abstract

The invention establishes a detection method for screening illegal additives in weight-reducing health food. Based on a real-time direct analysis ion source, the ionization process of a target samplecan be completed in a few seconds; by use of an orbitrap high resolution mass spectrometer is for data acquisition of charged ions entering the mass spectrometer to obtain high-resolution first-and second-level mass spectrometric signals by a full-scan-based data-associated scanning mode; and the illegal additives in the weight-reducing health food can be screened by use of ToxID software to rapidly screen and qualitatively process collected data. The method has the advantages of high sensitivity, strong selectivity, strong qualitative ability, and simple and quick operation (the data collection process is completed in a few seconds), retains the complete information of the measured objects to a greater extent, and can be used for rapid screening of the illegal additives in the weight-reducing health food.

Description

Technical field [0001] The invention relates to the technical field of analysis of weight-loss health foods, in particular to a detection method for detecting illegal additives in weight-loss health foods by real-time direct analysis of ion source-high resolution mass spectrometry. Background technique [0002] Overweight and obesity are the main risk factors for several chronic diseases including diabetes, cardiovascular disease and cancer. The Chinese Center for Disease Control and Prevention released the data obtained from the monitoring of chronic diseases and risk factors in the national disease detection areas in 2010. The overweight rate of residents aged 18 and above was 30.6% and the obesity rate was 12.0%. Faced with obesity, many people place their hopes on weight-loss health foods. As everyone knows, weight-loss health foods are often illegally added with chemical drugs such as sibutramine and phenolphthalein. After sorting out and counting 78 related research paper...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/62G01N1/28G01N1/38
CPCG01N27/62G01N1/28G01N1/38
Inventor 李建辉程甲严华赵善贞崔凤云韩深张朝晖刘鑫卢晓宇高洋洋
Owner BEIJING ENTRY EXIT INSPECTION & QUARANTINE BUREAU INSPECTION & QUARANTINE TECH CENT
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