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A pharmaceutical composition composed of aescin b or its sodium salt and niacin

A technique for aescin and a composition, applied in the field of pharmacy, can solve the problems of unstable quality of aescin products, difficulty in guaranteeing safety, etc., and achieves reduction of the degree of neurological deficit and mortality, alleviation of the phenomenon of dragging bubbles, and reduction of Effects of infarct volume and brain water content

Active Publication Date: 2021-10-08
WUHAN AIMIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, high-purity aescin B can solve the current problems of unstable quality of aescin products and difficulty in ensuring safety

Method used

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  • A pharmaceutical composition composed of aescin b or its sodium salt and niacin
  • A pharmaceutical composition composed of aescin b or its sodium salt and niacin
  • A pharmaceutical composition composed of aescin b or its sodium salt and niacin

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] The present invention will be described in detail below by way of examples.

[0015] Test drug:

[0016] Composition injection: mix aescin B and niacin at a weight ratio of 10:1, 7:2, and 5:3 respectively, dissolve in water for injection, and prepare an injection containing 5 mg of aescin B per ml.

[0017] Aescin B injection: Dissolve aescin B in water for injection to make an injection containing 5 mg of aescin B per ml.

[0018] Niacin injection: Dissolve nicotinic acid in water for injection to make an injection containing 5 mg of nicotinic acid per ml.

[0019] 1. Establish a model of cerebral ischemia-reperfusion injury in rats: male SD rats, weighing 230-250 g, were anesthetized by intraperitoneal injection of 25% urethane solution, fixed on the operating table in a lateral position, and made a median incision in the neck to expose the common carotid artery , separate the internal carotid artery, clamp the common carotid artery and the internal carotid artery, ...

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Abstract

The invention discloses a pharmaceutical composition for treating ischemic stroke, which consists of aescin B or its sodium salt and niacin, and the weight ratio of the aescin B or its sodium salt to niacin is 2-20:0.5-5. The composition provided by the invention can reduce the degree of neurological deficit and mortality in animal models of cerebral ischemia-reperfusion injury, reduce the infarction volume and brain water content caused by cerebral ischemia, significantly improve the activity of SOD in rat brain tissue, reduce The production of MDA protects cell membranes from free radical damage, increases LDH activity in ischemic brain tissue, and reduces lactic acid accumulation. It is an ideal drug for treating ischemic stroke.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a pharmaceutical composition for treating ischemic stroke composed of aescin B or its sodium salt and nicotinic acid. Background technique [0002] Aescin, also known as aescinic acid, is a triterpenoid saponin extracted from the seeds of Aescinaceae Aesculus, with a molecular formula of C 55 h 86 o 24 . Aescin has poor water solubility. In order to increase its solubility, it is often made into sodium salt. Aescin or its sodium salt has various effects such as anti-inflammatory and anti-edema, and can be used for the treatment of cerebral edema, trauma and other diseases . [0003] Aescin contains many kinds of saponin compounds, which are named as aescin A, aescin B, aescin C and aescin D in sequence according to the liquid phase before and after the peak. They are isomers of each other (see appendix figure 1 ), the currently clinically used aescin is a mixture of aesc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K31/455A61P9/10A61P25/00
CPCA61K31/455A61K31/704A61K2300/00
Inventor 石召华孙天鹏叶利春祝慧覃勤吴点杨楚红
Owner WUHAN AIMIN PHARMA