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Cimetidine content determination method

A technology of cimetidine and a determination method, which is applied in the field of content determination of cimetidine, can solve the problems of interference in determination and inability to accurately determine content, and achieves the effects of being suitable for application promotion, high recovery rate and high sensitivity

Inactive Publication Date: 2018-05-18
ZUNYI MEDICAL UNIVERSITY
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Problems solved by technology

[0003] In the original national standard content determination method, the content of cimetidine was measured with a UV-visible spectrophotometer. The wavelength of cimetidine was measured at 218nm, and the absorption was mainly at the ultraviolet end. It may be interfered during the measurement, and the content cannot be accurately measured.

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Embodiment Construction

[0025] Embodiments of the present invention: the assay method of cimetidine comprises the following steps:

[0026] 1) Preparation of cimetidine standard solution: Accurately weigh 100.0 mg of cimetidine reference substance, put it in a 100 mL volumetric flask, dissolve it with acetonitrile and dilute to the mark, and prepare a 1.0 mg / mL stock solution (refrigerator at 4°C) internal storage), and gradually diluted with acetonitrile to a working solution of 200.0ug / mL during analysis;

[0027] 2) preparation of cimetidine sample solution: get cimetidine sample, grind and mix, accurately take a certain amount of cimetidine sample, add acetonitrile to make it dissolve completely, filter, filtrate is placed in volumetric flask, Filter paper is washed 2 to 3 times with acetonitrile, and the combined filtrate and washings are diluted to the mark with acetonitrile to obtain the test solution of cimetidine;

[0028] 3) 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) solution: Accuratel...

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Abstract

The invention discloses a cimetidine content determination method, wherein the cimetidine content is detected by using the charge transfer complex generated from cimetidine and 2,3-dicyano-5,6-dichlorobenzoquinone (DDQ) in an acetonitrile solution. The cimetidine content determination method of the present invention can determine the contents of cimetidine tablets and cimetidine capsules in a rapidness, accuracy, high reproducibility and high recovery rate manner, can provide advantages of high sensitivity, high precision, high accuracy and good stability compared to the ultraviolet and visible spectrophotometry method in the Pharmacopoeia of People's Republic of China (2015 edition), is suitable for promotion application, and can provide important significance for the control of the quality of cimetidine preparations and the ensuring of clinical efficacy, wherein the accuracy, the repeatability, the linearity, the stability and other indexes of the content determination method can meet the requirements of scientific research and production.

Description

technical field [0001] The invention relates to the technical field of methods for determining the content of medicines, in particular to a method for determining the content of cimetidine. Background technique [0002] The main ingredient of cimetidine tablets, capsules and injections is cimetidine, and its chemical name is: N-cyano-N'-methyl-N”-[2-[[5-methyl-1H-imidazole -4-yl] methylthio] ethyl] guanidine, the molecular formula is C 10 h 16 N 6 S, is a selective H2 receptor antagonist for the treatment of peptic ulcer. Cimetidine was listed on the market in 1975. It mainly has the effect of inhibiting gastric acid secretion. It can obviously inhibit the secretion of gastric acid at night and at night. Its acidity is reduced, and it has preventive and protective effects on corrosive gastritis caused by chemical stimulation, and has obvious curative effect on stress gastric ulcer and upper gastrointestinal bleeding. [0003] In the original national standard content de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/31G01N1/38
CPCG01N21/3103G01N1/38
Inventor 余兰廖羽
Owner ZUNYI MEDICAL UNIVERSITY
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